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The Impact of Diabetes Mellitus in the United States
Epidemiology, Costs, and Future Projections This slide set provides an overview of the impact of type 1 and type 2 diabetes mellitus in the United States, focusing on epidemiology, costs—both direct and indirect—and the projected burden of diabetes, including globally 1
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Epidemiology of Diabetes
29.1 million Americans, 9.3% of the population, have diabetes Diagnosed: 21.0 million Undiagnosed: 8.1 million 1.25 million have type 1 diabetes Leading cause of kidney failure, nontraumatic lower-limb amputation, new cases of blindness among adults Major cause of heart disease and stroke Seventh leading cause of death National Diabetes Statistics, 2014 provides an overview of the epidemiology of diabetes in the United States Diabetes affects 29.1 million people of all ages, or 9.3% of the population Of that number, about one-third, or 8.1 million, have diabetes that is undiagnosed 21 million have diagnosed diabetes Diabetes is the leading cause of kidney failure, nontraumatic lower-limb amputation, and new cases of blindness among adults Diabetes is also a major cause of heart disease and stroke and is the seventh leading cause of death 1.25 million with type 1 diabetes is estimated from Statistics Report statement that 5% of people with diagnosed diabetes have type 1 and from diagnosed adult and youth prevalence data National Diabetes Information Clearinghouse. National Diabetes Statistics, Available at: Reference National Diabetes Information Clearinghouse. National Diabetes Statistics, Available at: 2
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Racial/Ethnic Differences in Diagnosed Diabetes
data for people ages ≥20 Years or Older Race/Ethnicity % Non-Hispanic whites 7.6 Asian Americans 9.0 Hispanics/Latinos Cuban Americans Central and South Americans Mexican Americans Puerto Ricans 12.8 9.3 8.5 13.9 14.8 American Indians/Alaska Natives 15.9 After adjusting for population age differences, 2010–2012 National Health Interview Survey and 2012 Indian Health Service’s National Patient Information Reporting System data for people ages 20 years or older indicated the percentage of racial/ethnic populations with a diagnosis of diabetes As indicated on this slide, Puerto Ricans, at 14.9% and Mexican Americans, at 13.9%, represented the populations with the highest percentage of diagnosed diabetes Non-Hispanic white had the lowest percentage, 7.6% Centers for Disease Control and Prevention 2014 National Diabetes Statistics Report Available Reference National Diabetes Information Clearinghouse. National Diabetes Statistics, Available at: 3
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Diagnosed and Undiagnosed Diabetes
The estimated percentage of people in the United States from 2012 age 20 years or older living with diabetes (diagnosed and undiagnosed) is summarized on this slide As the population ages, an increasing percentage is living with diabetes 20-44 years: 4.1% 45-64 years: 16.2% ≥65 years: 25.9% Source: 2009–2012 National Health and Nutrition Examination Survey estimates applied to 2012 U.S. Census data. Source: National Health and Nutrition Examination Survey National Diabetes Information Clearinghouse. National Diabetes Statistics, Available at: Reference National Diabetes Information Clearinghouse. National Diabetes Statistics, Available at: 4
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Number of Americans with Diagnosed Diabetes, 1980-2011
This slide highlights the number of civilian, noninstitutionalized persons with diagnosed diabetes in the United States from From 1980 through 2011, the number of Americans with diabetes has more than tripled, from 5.6 million to 20.9 million Source: Centers for Disease Control and Prevention, National Center for Health Statistics, Division of Health Interview Statistics, data from the National Health Interview Survey Centers for Disease Control and Prevention Reference Centers for Disease Control and Prevention. Number (in millions) of civilian, non-Institutionalized persons with diagnosed diabetes, United States, 1980–2009. Available at: 5
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Age-Adjusted Prevalence of Obesity and Diagnosed Diabetes Among US Adults
1994 Methodology The percent of U.S. adults who are obese or who have diagnosed diabetes was determined by using data from the Behavioral Risk Factor Surveillance System (BRFSS, available at An ongoing, yearly, state-based telephone survey of the non-institutionalized adult population in each state, the BRFSS provides state-specific information on behavioral risk factors for disease and on preventive health practices. Respondents who reported that a physician told them they had diabetes (other than during pregnancy) were considered to have diagnosed diabetes. Self reported weight and height were used to calculate body mass index (BMI): weight in kilograms divided by the square of height in meters. A BMI greater than or equal to 30 was considered to be obese. Rates were age-adjusted using the 2000 U.S. Standard Population. 6
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Age-Adjusted Prevalence of Obesity and Diagnosed Diabetes Among US Adults
2013 Methodology The percent of U.S. adults who are obese or who have diagnosed diabetes was determined by using data from the Behavioral Risk Factor Surveillance System (BRFSS, available at An ongoing, yearly, state-based telephone survey of the non-institutionalized adult population in each state, the BRFSS provides state-specific information on behavioral risk factors for disease and on preventive health practices. Respondents who reported that a physician told them they had diabetes (other than during pregnancy) were considered to have diagnosed diabetes. Self reported weight and height were used to calculate body mass index (BMI): weight in kilograms divided by the square of height in meters. A BMI greater than or equal to 30 was considered to be obese. Rates were age-adjusted using the 2000 U.S. Standard Population. 7
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Prevalence of Overweight and Obesity Among Adults with Diabetes
CDC analysis of prevalence of overweight and obesity among U.S. adults ≥20 years with previously diagnosed diabetes Overweight or obesity: 85.2% Obesity: 54.8% Women aged years had a significantly higher prevalence of obesity than women ≥65 years of age (64.7% vs 47.4%; P<0.05) during Among men, prevalence of overweight or obesity was 86.3% and obesity, 53.0% The Centers for Disease Control and Prevention (CDC) analyzed the prevalence of overweight and obesity among US adults aged ≥20 years with previously diagnosed diabetes by using data from two surveys: the Third National Health and Nutrition Examination Survey (NHANES III), , and NHANES This analysis found that most adults with diagnosed diabetes were overweight or obese; during , the prevalence of overweight or obesity was 85.2%, and the prevalence of obesity was 54.8% In NHANES III, , participants were asked, “Have you ever been told by a doctor that you have diabetes or sugar diabetes?” For women, the question was preceded by “other than during pregnancy” In NHANES , the same questions were asked, but “doctor” was replaced with “doctor or health-care professional” Participants who responded “yes” were categorized as having diagnosed diabetes The body mass index (BMI) of each participant was calculated as weight in kilograms divided by height in meters squared; overweight was defined as a BMI of and obesity as a BMI of ≥30.0 For the periods (45.7%) and (54.8%), prevalence of obesity was similar among all survey participants with diagnosed diabetes Among women in the survey, the prevalence of overweight or obesity was 84.2% and the prevalence of obesity was 58.0% Compared with women aged ≥65 years, women aged years had a significantly higher prevalence of obesity (64.7% vs 47.4%)(P<0.05) MMWR. 2004;53(45): Reference Centers for Disease Control and Prevention. Prevalence of overweight and obesity among adults with diagnosed diabetes—United States, and MMWR. 2004;53(45): 8
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Incidence and Prevalence of Diabetes in Youth, 2012
About 208,000 people younger than 20 have been diagnosed with diabetes (type 1 and type 2), about 0.25% of American youth In , 18,436 people younger than 20 years in the U.S. newly diagnosed with type 1 diabetes annually, and 5,089 diagnosed with type 2 diabetes SEARCH results were used to estimate the number of cases of diabetes mellitus in the US in 2001 154,369 (95% CI: 150, ,248) youth had physician-diagnosed diabetes The majority of these youth (78.7%, or 121,509) were ages years Non-Hispanic white youth represented 62% of the US population <20 years of age but 71% of all children with diabetes Of those 0-9 years, 32,860 youth had diabetes Similarly, non-Hispanic white youth had a disproportionate percentage of diabetes compared with the other racial/ethnic groups: they represented 60% of the population but 77% of all children with diabetes National Diabetes Information Clearinghouse. National Diabetes Statistics, Available at: Reference SEARCH for Diabetes in Youth Study Group. The burden of diabetes mellitus among US youth: prevalence estimates from the SEARCH for Diabetes in Youth Study. Pediatrics. 2006;118: 9
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Prediabetes In , based on fasting glucose or A1C levels, prediabetes was detected in 37% of adults ages 20 years and older 51% of adults ages 65 years and older An estimated 86 million adults ages 20 years and older People with prediabetes have an increased risk of developing type 2 diabetes, heart disease, and stroke 86 million adults ages 20 years and older are estimated to have prediabetes 37% were ages 20 years or older 51% were ages 65 years or older Prediabetes can lead to increased risk of developing type 2 diabetes, heart disease, and stroke Losing weight and increased physical activity can prevent or delay type 2 diabetes in those with prediabetes; in some cases, blood glucose levels return to normal National Diabetes Information Clearinghouse. National Diabetes Statistics, Available at: Reference National Diabetes Information Clearinghouse. National Diabetes Statistics, Available at: 10
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Complications of Diabetes
Hypertension Hyperlipidemia Heart disease and stroke Blindness, eye problems Renal disease Amputations Other complications Complications of diabetes are included on this slide; the following slides summarize those of heart disease and stroke, hypertension, blindness, eye problems, nervous system disease and amputations In addition, periodontal disease is more common in those with diabetes Other complications include nerve disease, nonalcoholic fatty liver disease, periodontal (gum) disease, hearing loss, erectile dysfunction, depression, and complications of pregnancy, among others. National Diabetes Information Clearinghouse. National Diabetes Statistics, Available at: Reference National Diabetes Information Clearinghouse. National Diabetes Statistics, Available at: 11
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Complications of Diabetes Heart Disease, Stroke, Hypertension
In 2009–2012, of adults aged >18 years with diagnosed diabetes, 71% had blood pressure >140/90 mmHg or used blood pressure medications In 2003–2006 cardiovascular disease death rates were about 1.7 times higher among adults aged >18 with diagnosed diabetes than among adults without diagnosed diabetes In 2010 hospitalization rates for heart attack were 1.8 times higher and stroke were 1.5 times higher among adults with diagnosed diabetes >20 compared to those without diagnosed diabetes In 2004, heart disease was noted on 68% of diabetes-related death certificates among people ages ≥65 years and stroke was noted on 16% Adults with diabetes have death rates approximately 2-4 times higher from heart disease compared to those without diabetes Risk for stroke is 2-4 times higher among people with diabetes In , 67% of adults ages 20 years or older with diabetes had hypertension (≥140/90 mmHg) or used prescription medications for hypertension National Diabetes Information Clearinghouse. National Diabetes Statistics, Available at: Reference National Diabetes Information Clearinghouse. National Diabetes Statistics, Available at: 12
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Complications of Diabetes Blindness, Eye Problems
Diabetes is leading cause of new cases of blindness among adults ages 20–74 years Of people with diabetes aged ≥40 years, 4.2 million (28.5%) had diabetic retinopathy in 655,000 (4.4% of those with diabetes) had advanced diabetic retinopathy that could lead to severe vision loss Among adults ages years, diabetes is the leading cause of new cases of blindness In , 4.2 million people with diabetes ages 40 years and older (28.5%) had diabetic retinopathy and of these, 655,000 (4.4% of those with diabetes) had advanced diabetic retinopathy that could lead to severe vision loss National Diabetes Information Clearinghouse. National Diabetes Statistics, Available at: Reference National Diabetes Information Clearinghouse. National Diabetes Statistics, Available at: 13
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Complications of Diabetes Renal Disease
In 2011, diabetes was leading cause of kidney failure, accounting for 44% of all new cases of renal failure 49,677 people with diabetes began treatment for end-stage renal disease (ESRD) 228,942 people with ESRD due to diabetes were living on chronic dialysis or with a kidney transplant 44% of all new cases of kidney failure in 2008 were caused by diabetes Also in 2011 49,677 began treatment for end-stage renal disease 228,942 people with ESRD due to diabetes were living on chronic dialysis or with a kidney transplant National Diabetes Information Clearinghouse. National Diabetes Statistics, Available at: Reference National Diabetes Information Clearinghouse. National Diabetes Statistics, Available at: 14
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Trends in age-standardized rates of diabetes-related complications among U.S. adults with diabetes, Rates of all five complications declined between 1990 and 2010, with the largest relative declines in acute myocardial infarction (-67.8%; 95% confidence interval [CI], to -59.3) and death from hyperglycemic crisis (-64.4%; 95% CI, to -60.9), followed by stroke and amputations, which each declined by approximately half (-52.7% and -51.4%, respectively); the smallest decline was in end-stage renal disease (-28.3%; 95% CI, to -21.6). The greatest absolute decline was in the number of cases of acute myocardial infarction (95.6 fewer cases per 10,000 persons; 95% CI, 76.6 to 114.6), and the smallest absolute decline was in the number of deaths from hyperglycemic crisis (-2.7; 95% CI, -2.4 to -3.0). P < 0.01% for all changes. Gregg et al. N Engl J Med 370: 1514—1523, 2014 Reference National Diabetes Information Clearinghouse. National Diabetes Statistics, Available at: 15
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Complications of Diabetes Nervous System Disease
~60%–70% of people with diabetes have mild to severe forms of nervous system damage Impaired sensation or pain in feet or hands Slowed digestion of food in the stomach Carpal tunnel syndrome Erectile dysfunction Severe forms are a major contributing cause of lower-extremity amputations: About 60% occur in people with diabetes ages ≥20 60%-70% of people with diabetes have mild to severe forms of nervous system damage, including neuropathy, erectile dysfunction, or carpal tunnel syndrome About 60% of nontraumatic lower-limb amputations occur in those with diabetes Reference National Diabetes Information Clearinghouse. National Diabetes Statistics, Available at: 16
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Deaths Among People with Diabetes
In 2010, diabetes was the seventh leading cause of death based on death certificates 69,071 underlying cause 234,051 contributing cause Likely to be underreported as a cause of death Overall, risk for death among those with diabetes is about twice that of people with similar age but without diabetes Based on US death certificates in 2010, diabetes was the seventh leading cause of death in which diabetes appeared as any-listed cause of death This ranking is based on 69,071 death certificates that listed diabetes as the underlying cause of death and 234,051 in which diabetes was listed as a contributing cause of death Diabetes is likely to be underreported as a cause of death; studies have found that 35%-40% of those who died had diabetes listed anywhere on the death certificate; in about 10%-15%, it was listed as the underlying cause of death Risk for death among people with diabetes is 1.5 times higher than that of people of a similar age who do not have diabetes National Diabetes Information Clearinghouse. National Diabetes Statistics, Available at: Reference National Diabetes Information Clearinghouse. National Diabetes Statistics, Available at: 17
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Section 2 Section 2, Costs, examines the economic costs of diabetes, including medical expenditures, health resource use, health care expenditures, indirect costs, and mortality costs attributed to diabetes COSTS 18
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Economic Costs of Diabetes, 2012
Total cost of diabetes: $245 billion $176 billion in direct medical costs, which includes costs for hospital and emergency care, office visits, and medications. $69 billion in indirect medical costs, which includes costs for absenteeism, reduced productivity, unemployment Diabetes is a disease that touches almost everyone in society and nowhere is this more true than with respect to costs of diabetes In 2007, diabetes cost the US an estimated $254 billion; $176 billion in excess medical expenditures and $69 billion in reduction in national productivity American Diabetes Association. Diabetes Care. 2013;36: Reference American Diabetes Association. Economic costs of diabetes in the U.S. in Diabetes Care. 2008;31: 19
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Medical Expenditures Attributed to Diabetes, 2012
Hospital inpatient care (43%) Retail prescriptions to treat complications of diabetes (18%) Diabetes medication and supplies (12%) Physician office visits (9%) Nursing/residential facility stays (8%) The absolute cost of hospital inpatient care for people with diabetes rose from $58 billion in 2007 to $76 billion in However, hospital inpatient care costs fell from 50 percent to 43 percent of total direct medical costs. The largest components of medical expenditures attributed to diabetes were Hospital inpatient care (43% of total costs) Retail prescriptions to treat complications of diabetes (18%) Diabetes medication and supplies (12%) Physician office visits (9%) Nursing/residential facility stays (8%) American Diabetes Association. Diabetes Care. 2013;36: Reference American Diabetes Association. Economic costs of diabetes in the U.S. in Diabetes Care. 2008;31: 20
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Costs Incurred by People with a Diagnosis of Diabetes in 2012
Average annual expenditures: $13,700 $7,900 attributed to directly to diabetes Medical expenditures for people with diabetes are 2.3 times higher than for those without diabetes. More than 1 in 5 health care dollars in the U.S. goes to the care of people with diagnosed diabetes More than 1 in 10 health care dollars in the U.S. are spent directly on diabetes and its complications People with a diagnosis of diabetes incur average expenditures of $11,744 annually, of which $6,649 is attributed to diabetes Medical expenditures for those with a diagnosis of diabetes are, on average, approximately 2.3 times higher than what expenditures would be in the absence of diabetes For the cost categories analyzed, approximately $1 in $5 health care dollars is spent caring for someone with a diagnosis of diabetes, while approximately $1 in $10 health care dollars is attributed to the disease itself American Diabetes Association. Diabetes Care. 2013;36: Reference American Diabetes Association. Economic costs of diabetes in the U.S. in Diabetes Care. 2008;31: 21
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Health Care Expenditures in the U.S Attributed to Diabetes, 2012
Health resource Dollars ($ millions) % of U.S. total Institutional care Hospital inpatient Nursing/residential facility Hospice 75,872 14,748 32 16% 17% 0.3% Outpatient care Office-based physician visits Emergency visits Ambulance services Hospital outpatient Home health Podiatry 15,221 6,654 218 5,027 4,466 212 8% 6% 11% 9% 12% These data illustrate the estimated health resource use attributed to diabetes by type of service, aggregated into the age categories younger than 45 years; years, and older than 65 years of age The population group aged 65 years and older was found to use a large proportion of services, reflecting the burden diabetes places on the Medicare program American Diabetes Association. Diabetes Care. 2013;36: Table 4. Reference American Diabetes Association. Economic costs of diabetes in the U.S. in Diabetes Care. 2008;31: 22
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Indirect Costs Attributed to Diabetes, 2012
Cost component Productivity loss Total cost attributable to diabetes ($ billions) Proportion of indirect costs (%) Workdays absent 25 million days 5.0 7 Reduced performance at work 113 million days 20.8 30 Reduced productivity days for those not in labor force 20 million days 2.7 4 Reduced labor force participation due to disability 130 million days 21.6 31 Mortality 246,000 deaths 18.5 27 Total 68.6 100 The number of workdays absent because of diabetes in 2007 was estimated at 15 million, at a national cost of $2.6 billion Reduced performance at work, or “presenteeism,” was estimated at 120 million lost workdays, with an estimated national cost of $20 billion The estimated productivity loss for those not in the labor force was equivalent to 6 million days, with a national cost of $800 million At any given time during 2007, approximately 16 million people were unemployed and receiving Supplemental Security Income (SSI) payments due to disability More than 1 million of these people had diabetes More than 445,000 cases of unemployment were attributed to diabetes, equating to 107 million lost workdays at a national cost of $7.9 billion An estimated 284,000 deaths in 2007 were attributed to diabetes (see Slide 26) Total cost attributable to diabetes was $58.2 billion American Diabetes Association. Diabetes Care. 2013;36: Table 9. Reference American Diabetes Association. Economic costs of diabetes in the U.S. in Diabetes Care. 2008;31: 23
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Mortality Costs Attributed to Diabetes, 2012
Primary cause of death Total US deaths Deaths attributed to diabetes Deaths % of total of US deaths Value of lost productivity ($ millions) Diabetes 73,000 100.0 7,147 Renal disease 46,000 25,000 55.0 2,004 Cerebrovascular disease 136,000 38,000 28.0 1,484 Cardiovascular disease 687,000 110,000 16.0 7,827 Total NA* 246,000 18,462 An estimated 284,000 deaths in 2007 were attributed to diabetes, including: 77,000 deaths where diabetes was listed as the primary cause of death 123,000 deaths where cardiovascular disease was listed as the primary cause of death (with 16.5% of national deaths from cardiovascular disease attributed to diabetes) 59,000 deaths where cerebrovascular disease was listed as the primary cause of death; and 5,000 deaths where renal disease was listed as the primary cause of death Taking into account the age and sex distribution of these deaths, the value of lost productivity from premature mortality is $26.9 billion *Total comprises mortality for reasons other than those listed here American Diabetes Association. Diabetes Care. 2013;36: Table 10. Reference American Diabetes Association. Economic costs of diabetes in the U.S. in Diabetes Care. 2008;31: 24
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Economic Costs of Prediabetes, GDM and Diabetes, 2012
Total national cost: $322 billion Higher medical costs: $244 billion Productivity loss: $78 billion $245 billion for diagnosed diabetes $32.8 billion for undiagnosed diabetes $43.9 billion for prediabetes $1.3 billion for gestational diabetes A cost of Diabetes Model was used to estimate the U.S. economic burden associated with diabetes These revised estimates suggesting the US national economic burden is even higher: $322 billion, which includes $244 billion in higher medical costs and $78 billion in productivity loss Specifically, the $322 billion comprises $245billion for diagnosed diabetes, $32.8 billion for undiagnosed diabetes, $43.9 billion for prediabetes, and $1.3 billion for gestational diabetes Dall TM, et al. Diabetes Care. 2014; 3172–3179. Reference Dall TM, Zhang Y, Chen YJ, Quick WW, Yang WG, Fogli J. The economic burden of diabetes. Health Affairs. 2010;29(2): 25
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FUTURE PROJECTIONS Section 3
Section 3, Future Projections, examines International Diabetes Federation global projections for the number of people with diabetes, as well as the number of people with diabetes ages years, 2010 and 2030, by the top 10 countries In addition, a model provides an estimate of the future burden of diabetes through 2050 FUTURE PROJECTIONS 26
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Estimated Number of People with Diabetes Worldwide, 2010 and 2030
Country/Territory 2010 Millions 2030 1 India 50.8 87.0 2 China 43.2 62.6 3 USA 26.8 36.0 4 Russian Federation 9.6 Pakistan 13.8 5 Brazil 7.6 12.7 6 Germany 7.5 Indonesia 12.0 7 7.1 Mexico 11.9 8 Japan Bangladesh 10.4 9 7.0 10.3 10 6.8 Egypt 8.6 In 2009, the International Diabetes Federation estimated the number of people with diabetes ages years in 2010 and 2030 by top 10 country (or territory) India, China, and the United States had the greatest number of people with diabetes in 2010, and these countries are expected not only to maintain this ranking but see their population of those with diabetes increase by more than 65 million IDF Diabetes Atlas, 4th ed. ©International Diabetes Federation, 2009. Reference International Diabetes Foundation. IDF Diabetes Atlas, 4th ed Available at: 27
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Annual U.S. Diabetes Burden in 2050
By 2050, prevalence of total diabetes (diagnosed and undiagnosed) is projected to increase from 1 in 10 adults to between 1 in 5 and 1 in 3 adults Incidence: from 8 in 1000 to 15 in 1000 Largely attributed to three key factors Aging of the U.S. population Increasing size of higher-risk minority populations Declining mortality among those with diabetes Results indicate that by the year 2050, the prevalence of total diabetes, both diagnosed and undiagnosed, is projected to increase from 1 in 10 U.S. adults to between 1 in 5 and 1 in 3 adults The annual incidence of new cases of diagnosed diabetes is projected to increase from 8 cases per 1000 in 2008 to approximately 15 cases per 1000 by the year 2050 The projected increases are largely attributed to three key demographic factors The aging of the US population Increasing size of higher-risk minority populations in the population; and Declining mortality among people with diabetes Boyle JP, et al. Popul Health Metr. 2010;8:29. Reference Boyle JP, Thompson TJ, Gregg EW, Barker LE, Williamson DF. Projection of the year 2050 burden of diabetes in the US adult population: dynamic modeling of incidence, mortality, and prediabetes prevalence. Popul Health Metr. 2010;8:29. 28
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Total U.S. Adult Population Diabetes Prevalence Projections
This figure illustrates projections of total diabetes prevalence as a percentage of the total U.S. adult population for four scenarios Low incidence projections and r1=1.77, r2=2.11; low incidence projections and r1=1.00 and r2=4.08; middle incidence projections and r1=1.77, r2=2.11; middle incidence projections and r1=1.00, r2=4.08 [Data not shown] Total diabetes prevalence is projected to increase from 14% of the U.S. adult population in to as high as 33% in 2050, based on the following scenarios: Low incidence, high mortality: to 21% Middle incidence: to 25% to 28% High incidence, low mortality: to 33% Boyle JP, et al. Popul Health Metr. 2010;8:29. Reference Boyle JP, Thompson TJ, Gregg EW, Barker LE, Williamson DF. Projection of the year 2050 burden of diabetes in the US adult population: dynamic modeling of incidence, mortality, and prediabetes prevalence. Popul Health Metr. 2010;8:29. 29
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