1. MOTIC VM600 Virtual Microscope
Development of Motic’s New Model; Features & Improvements, Model Strategy, and Model Competition Motic International Dealer Meeting March 2009

2. Topics Covered Motic VM Introduction: Hardware & Softwares
Application solutions:
Clinical Diagnosis/
Consultation, Research
Education
VM System Operation & software
Competitive Analysis

3. Motic Products Solution
1、DPCC（ Digital Pathology Consultation & Communication Platform ）
VM600-4：Digital Slide Scanner
2、DSS（ Digital Slide Server System ）
VM：Digital Slide View software

4. Motic VM Components (Hardware & Scanning software))4

5. Scanning Process Demo：

6. Digital Slide View Demo

7. Motic Pro 285 CCD 1. Motic 285A： 2/3 " , 1360 x 1024, 6.45m x 6.45m
MCAM285 Technical Data
　Item
MCAM285
Sensor Size
2/3"CCD
Resolution
1.4 mega pixels, 1360 X 1024 pixels
Pixel Size
6.45m x 6.45m
Frame Rate
15 fps / second
Shutter
Electronic
Dynamic Range
>44db S/N
Scanning System
Progressive
Minimum Illumination
≈3Lux
USB Interface
USB2.0(480Mbit/sec
Voltage
DC 5V± 5%
Operating Current
≈260mA
Power Consumption
≈1.3W
Operating Temperature
0℃-50℃
Storage Temperature
0℃-60℃
Relative Humidity
40%-80%
OS recommended
WINDOWS2000 / WINXP / VISTA

8. Scanning Speed Objective: 20x； Specimen：10mmx10mm；
Scanning Method: Standard；
Speed：About 4 min

9. VM600 Stage Configuration
X - 272mm；Y - 196mm；Z - 93mm ;
Travel range of 80mm by 24mm
Stage Accuracy:
1.5625um for x/y –axis,;
0.015um for z-axis;
Relocation Accuracy: <1um

10. Motic VM600 Recommended PC Specifications
Workstation System:
Windows XP Professional
Intel Core(TM) 2 processors
4GB RAM
300GB disk storage
22 “ Monitor(or larger Optional)

11. Motic VM Scanning Methodology
1. High Precision
Auto –Focus every Image , high quality
2. Standard ：
Build Scanning model , good quality with faster scanning speeds
3. ROI（Region of Interest）:
Scan whole slide with low magnification(2x or 4x) first, then scan ROI with higher magnification . Small Digital slide Size(<10M), useful and convenient for pathology or educational applications (Motic only feature)
4.Multilayer Focus:
Multilayer focus and amalgamation each tiled image . Very high quality ,especially for thick glass slide (but may be too slow for most applications)

12. Multilayer Focus Scanning

13. Multi-Layer Amalgamation

14. Traditional Pathology Workflow
Surgery Center
Pathology Center
Living specimen
Freezes
Tissue
Fix, Dehydrate, Embedding….
Histo-processing
Slide
Staining
Tissue
specimen
Pathology Education
Pathology Diagnosis
Slides
Pathologist Center

15. Digital Pathology Solution: Adjusting Standard Workflows
Surgery Center
Pathology Center
Living specimen
Fix, Dehydrate, Embedding….
Histo-processing
Slide
Staining
Slide
Freezes Tissue
Tissue
specimen
Education
Image Analysis
Pathology Diagnosis &Analysis
Workflow Management
Digital Slides
Remote-Consultation
Pathologist Center

16. Future Digital Pathology Directions
Information Workflow, including Digital Slides…
Integrated Patient records (HIS/PACS…)
Education & Clinical
Remote-Consultation
Image analysis

17. MOTIC’s Digital Development Makes the VM600 The Next Logical Progression …
Microscope
Micro+Camera
Digital Pathology

18. VM Application Solutions

19. VM600 Digital Slide Applications
Educational (Cell Morphology, Histology, Pathology, etc.)
Digital Slides Classroom Teaching
Remote Teaching and Learning
Virtual (Web) Teaching Lab for Images view and conference
Clinical Diagnosis(Pathology)
Digital Images Data and workflow Management
Remote Consultation
Digital Slides Conference
Aided Diagnosis
Research
Digital Slides Data
TMA
Image analysis
Pharmaceuticals

20. VM Educational Applications

21. Digital slides Education System for Pathology and Histology Teaching
Classroom Teaching
1. Digital Slides reduce concerns about slide making, loss, breakage or fading;
2. Archive and share critical slides;
3. Built-in Digital Slide information management to reduce teacher prep time for course development and dedicate more time to viewing
Digital slides Testing
1. Manage digital slides to create a test library as an effective means for distributing testing materials;
2. Auto testing
Digital Slides gallery( Web view)
1. Anywhere , anytime access via internet on web, Pre- learning and Review ;
2. Improving the teaching level and learning effectively;

22. Motic Digital Slides Server Software System(DSS)
Lan/Internet
IE View
DSS Server
Web-Based
IE View
workstation
Motic VM

23. Motic Digital Slides Server System(DSS)
Web-Based
View by annotation , convenient for teaching and learning

24. Incorporating VM600 with Motic Net as an effective teaching tool..
Education (VM600 with Motic Net)

25. For Pathology Diagnosis (Secondary) & Consultation

27. Motic VM Feature:
Observe slide by Motic VM whiling or after scanning the slide ,it is the best way for beginning of diagnosing training

28. Digital Pathology Consultation & digital slide Communication Platform
Remote Experts
DPCC Platform
LAN or Internet
（ADSL）
Remote Consultation
Center
LAN or Internet
（ADSL）
Motic VM
Consultation station
On business or at home

29. Motic DPCC Platform Web Address

30. PIS Digital Pathology Information Workflow HIS Digital Slides
Motic VM
HIS
Info Management
Patient Information
DICOM
PIS
Digital Slides
Workflow
Remote Consultation
Report
Conference
Internet)

31. Competitive Analysis

32. Market Sector Competitors
Zeiss Mirax
Olympus Bliss HD or .slide
Aperio
Hamamatsu NDP
Nikon Coolscope
6. Claro
DMetrix ……

33. Zeiss Mirax DESK(1-slide) Mirax MIDI(12-slide) Mirax SCAN(300-slide)
Objective: Plan-Apochromat 20x/0.8
Scan camera:
SONY DFW-X710 or others
(1/3“inch, 1024 x 768 pixels, cell size x 4.65 µm ) 

34. Zeiss (3DHISTECH,Hungarian company)
MIRAX Viewer - the virtual microscope MIRAX MFM - fluorescent slide viewer MIRAX TMA - a powerful tool for high throughput tissue microarray evaluation IH-Lab - software for fast evaluation of immunohistochemistry stained samples HistoQuant - quantitative and qualitative analysis application MIRAX E-School - teaching material authoring tool with exam module MIRAX 3D - an application for 3-dimensional reconstruction of serial slides E-Consult – teleconsultation software MIRAX DB - database program for efficient data management ToxicoPath-LIS - application for the management and administration of toxicopathology research

35. Olympus Dot slide(1-slide/50-slide)
Objectives : 2x PLAPON, 10x, 20x, 40x UPLSAPO, optional, e.g. 100x oil
Illumination: brightfield with 100 W halogen lamp house, optional: fluorescence, polarisation
Digital CCD camera: 2/3” CCD camera, 6.45 μm x 6.45 μm pixel size
Software functions and modules
.View images locally, zoom, crop and rotate images
.Net Image Server software for remote access to virtual slides with dotSlide software
.Conferencing module for simultaneous and synchronised viewing of virtual slides, conference access control and user management, minute taking tool, chat function
.TMA module to acquire individual images of TMA cores
Bacus: Bacus Laboratories,inc., a wholly-owned subsidiary of Olympus America . Founded in 1994, is a leader and innovator in the field of VM.

36. Hamamastu NDP: 210-slide Objective lens: 20X, NA 0.7
CCD: TDI sensor,4096 x 64 pixel , Line scanning
Software: Developed by other company
Distributed now in the USA through the Olympus network, approx cost $120K

37. Aperio Objective lens: PLAN-APO 20x / 0.75
CCD: Line 3-CCD, 1040 x 1 pixel
120-slide
5-slide
1 -slide
1-slide(Oil)

39. Nikon CoolScope CCD:2/3-inch.
(total number of pixels: 5.24-mega pixels;
effective 5.07-mega pixels)

40. Dmetrix .Objective : Array Micro lens (80)
.The fastest scanning system

41. Claro(Japan) Toco: 1-slide VS0201AS1 : 20-slide VS0801AS1: 80-slide
Objective: Carl Zeiss Aplan 20x, 40x
Camera: 1/2 CMOS (1280 x 1024) or 1/2 IT CCD' (1280 x 960)

42. Clarient/Trestle/Dako
Clarient: formed in 1996 to develop and market the ACIS(R) Automated Cellular Imaging System, in cancer diagnostics
Sells Its ACIS Instrument Business to Carl Zeiss for $12.5 Million
Following the acquisition of Trestle and of Clarient's equipment business, Carl Zeiss has become the leading provider of solutions for telepathology, digital slides and computer- supported diagnostics with more than 500 installed systems.
In marketing a clinical version of the system, Carl Zeiss MicroImaging said it is collaborating with the Danish diagnostics company Dako, a manufacturer of reagents for tissue-based cancer diagnosis.

43. Motic’s Strategic Positioning:
Natural Digital progression for Motic into Virtual slide making market
Offer “single-source” complete and easy integrated with VM hardware and software
Package Applications by combining VM Digital slide with Motic Net
Highest Resolution Sony CCD
Different scanning methods; ROI slide for remote consultation
Value-Alternative to customer
Motic: Value-Based alternative to easy and efficient digital slide creation and integration!