1. TriCurin TM - a novel therapeutic for human papillomavirus infection™
TriCurin TM - a novel therapeutic for human papillomavirus infection
Fighting HPV - Synergy of Science & Nature's Evolution
Co-founder & President
Mario Castellanos, MD

2. Human Papillomavirus Infection is a Growing Epidemic, Yet Lacks Treatment Options
700,000 Chronic
HPV Infections
270,000
precancers
10,000
cancers
US Annual Figures Cervical HPV (+) Disease
- 14 Million new HPV infections a year (US)
2nd most common STD
-10 % HPV infections become persistent, drive
malignancies
- $4 billion spent in diagnosis and treatment
- No antivirals to prevent cancer
- Multiple Billion Dollar market opportunity
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3. TriCurin™ is a Targeted Therapy to Cure HPV Infection
Tricurin is a novel formulation of 3 plant compounds
that directly block HPV replication
Induce apoptosis in HPV-infected lesions
Spare normal tissue
Inhibition of HPV E6 & E7 proteins
Essential for viral replication
Abnormal levels induce cancer
Lead Indication
Treatment of chronic cervical HPV infection
Cream for self administration, easy to use
Protected by global patent estate
E6 & E7 E4
L1 & L2
E1, E2 & E5
HPV
Squamous
Epithelium
Basement
Membrane
Mukherjee S, et al. Oncotarget 2017 In Press.
Debata PR, et al Gynecol Oncol 2013;129(1):145-53
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4. Phase I Proof of Concept Design
Clinical Trials
Phase I clinical trial
Women with chronic cervical HPV infection
Primary endpoint: Safety and tolerability
Secondary: Clinical efficacy (viral load, biomarkers)
Clinical site: Northwell Health
Time to completion: 1 year
Established Phase 2 & 3 trials
Post Phase I: Typical development programs for NDA submission (time 4 years)
Potential launch : 4-5 years post Phase I trial
IND
Phase 1 Trial
Phase 2 Trial
Phase 3 Trial
FDA
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5. Management Team Co-Founder & Director, Business Development
Alia Kozlova, PhD
Richmond Green, DOO, Co-founder
Head of Strategy & Planning, BAT, Regional and Area level
General Manager Russia & CIS, Middle East
Marketing Research Bureau
Director, Clinical Program
Anita Szerszen, DO
IRB Chair, Northwell Health
Research Director, Geriatrics Division Northwell Health, Staten Island
Co-Founder & President
Mario Castellanos, MD
Director Medical Women’s Health
Clinical Director Research, Northwell Health
Department of Medicine, Staten Island
Chief Executive Officer
Mike Wassil, CPA
Experienced C-Level Executive
30 years of experience
Participated in over 50 M&A,
Managed two IPO’s
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6. Job Description - Clinical Project Manager
Strategically thinking, highly motivated person to join our team...
Summary
Assist to acquire the IND and implement the start of the Phase I clinical trial
Key Knowledge & Skills
Science and/Clinical degree (PhD, MD, MS, RN, or MPH)
Excellent interpersonal and communication skills (verbal and written)
Strong organizational and time management skills
Self-motivation and attention to detail
Responsibilities & Duties
1) Working with
Academic &industry laboratories
consultants and CRO’s
Innovene ‘s Business and Clinical team
2) Assist in writing sections of the IND
3) Develop SOP’s
4) Interact with Clinical site & investigators
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7. Thank Y u Contact Mario@InnoveneMeds.com 718-809-2183