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Predictors of survival in restrictive chronic lung allograft dysfunction after lung transplantation  Stijn E. Verleden, PhD, David Ruttens, MD, Elly Vandermeulen,

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Presentation on theme: "Predictors of survival in restrictive chronic lung allograft dysfunction after lung transplantation  Stijn E. Verleden, PhD, David Ruttens, MD, Elly Vandermeulen,"— Presentation transcript:

1 Predictors of survival in restrictive chronic lung allograft dysfunction after lung transplantation 
Stijn E. Verleden, PhD, David Ruttens, MD, Elly Vandermeulen, Ir, Hannelore Bellon, Ir, Adriana Dubbeldam, MD, Walter De Wever, MD, PhD, Lieven J. Dupont, MD, PhD, Dirk E. Van Raemdonck, MD, PhD, Bart M. Vanaudenaerde, PhD, Geert M. Verleden, MD, PhD, Christian Benden, MD, FCCP, Robin Vos, MD, PhD  The Journal of Heart and Lung Transplantation  Volume 35, Issue 9, Pages (September 2016) DOI: /j.healun Copyright © 2016 International Society for Heart and Lung Transplantation Terms and Conditions

2 Figure 1 Graft loss in patients diagnosed with rCLAD for the Zurich, Leuven and total cohorts. Median time to graft loss was 1.1 years in the total cohort. One-, 3- and 5-year survival was 55%, 24% and 6%, respectively. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © 2016 International Society for Heart and Lung Transplantation Terms and Conditions

3 Figure 2 (A) Graft loss in patients diagnosed with rCLAD sub-divided based on the localization of CT infiltrates at the moment of rCLAD diagnosis. Better survival was observed in patients with upper lobe infiltrates compared with diffuse or lower lobe infiltrates (p = ). Median survival was 2.2 years, 0.6 year and 0.3 year for apical, basal and diffuse presence of CT infiltrates, respectively. (B) Representative example of high-resolution CT (HRCT) chest scan with upper lobe predominant infiltrates. (C) Example of HRCT scan with diffuse infiltrates. (D) Representative example of HRCT scan with lower lobe predominance. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © 2016 International Society for Heart and Lung Transplantation Terms and Conditions

4 Figure 3 (A) ROC curve for 1-year mortality after rCLAD diagnosis based on absolute blood eosinophil count. Absolute blood eosinophilia was a good predictor of 1-year mortality (p = , area under the curve = 0.80). Blood eosinophilia >240 × 106/liter had 71% sensitivity and 86% specificity to predict 1-year survival. (B) Log-rank comparison of patients with absolute eosinophil count >240 × 106/liter and ≤240 × 106/liter. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © 2016 International Society for Heart and Lung Transplantation Terms and Conditions

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