1. hemolytic-uremic syndrome (HUS) Dr. Nariman fahmi pediatric/2014

2. objectives Definition Classifications Pathogenesis
Clinical manifestations
Diagnosis
management

3. Definition
The most common cause of acute renal failure in young children
It is classically characterized by the triad of
microangiopathic hemolytic anemia
Thrombocytopenia
uremia

4. classifications
Typical HUS
Atypical HUS

5. Hemorrhagic E. coli (O157:H7) is a different strain of E
Hemorrhagic E. coli (O157:H7) is a different strain of E.coli that causes serious intestinal illness in humans. E. Coli is killed when meats are cooked thoroughly.

6. Diarrhea form is usually transmitted by undercooked meat or unpasteurized milk
eating contaminated milk, cheese,Iettuce

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10. The diagnosis is supported by the findings of a
microangiopathic hemolytic anemia
thrombocytopenia
and acute renal failure

12. -Mild renal insufficiency
Renal manifestations
vary from
-Mild renal insufficiency
-Acute oliguric or Anuric renal failure requiring dialysis.

13. COMPLICATIONS Anemia Acidosis Hyperkalemia Fluid overload
Heart failure
Hypertension
Uremia.

14. Extra renal manifestations
Central nervous system dysfunction includes irritability, seizures, coma.
Gastrointestinal manifestations
ischemic or inflammatory colitis, intestinal perforation, intussusception
acute pancreatitis
Arrhythmias ,others

15. management Early institution of dialysis
Blood transfusion for symptomatic anemia
Early institution of dialysis

16. Management Blood transfusion for symptomatic anemia
control of hypertension
meticulous attention to fluid and electrolytes
Early institution of dialysis
NO Antibiotic therapy for E. coli 0157: H7 it will increase risk of HUS

17. prognosis
With aggressive management of acute renal failure more than 90% of patients survive the acute phase of HUS with a diarrheal prodrome.

18. THANK YOU