1. INOLINK The Leading French Science Park Is happy to welcome
The members of
the EU Consortium
INOLINK
29 September 2010
Consortium INOLINK - 29 September 2010

2. Consortium INOLINK - 29 September 2010
Genopole: the historical French biopark
A continuum dedicated to biotechnology
Research
Companies
Hospital
University
Consortium INOLINK - 29 September 2010 2

3. Medicen Paris Region Bio-cluster
Fully integrated in the Medicen Paris Region Biocluster
Medicen Paris Region Bio-cluster
Top 1 in Europe for S&T
7,5 % GDP devoted to R&D
8 bioparks
150+ biotech companies
324 pharma companies
363 medical equipment companies
90% of French CROs
300 public and private research centers
largest european hospital system
41 state-run hospitals ( beds)
hot spot for clinical trials 3 
Consortium INOLINK - 29 September 2010

4. Building the most favorable environment to develop biotech companies…
Stimulating scientific
environment
International network
Versatile real estate offers and services
Pre seed Fund
Biotech Companies
Clinical network
Shared technical platforms
Instruments and programs for company incubation and development 4
Consortium INOLINK - 29 September 2010

5. Consortium INOLINK - 29 September 2010
A stimulating scientific environment
20 research labs, including 3 national-scale centres
900+ scientists
from most National Research Institutes: CNRS, CEA, INSERM, INRA, …
Evry University and 3 Schools of Engineering
students (34 % in sciences and engineering)
400 professors
Ambitious Integrative Programs
Institute for Stem Cells (2005)
Institute of Systems and Synthetic Biology (2009)
Institute for Biomaterials (2010) 5
Consortium INOLINK - 29 September 2010

6. Consortium INOLINK - 29 September 2010
Real estate: 86,000 m² dedicated to biotech companies
Facilities include space from offices to entrepreneurs…
Business center: fully furnished offices, meting rooms,…
… to customized tenant laboratory & office space
Incubator, with shared laboratory equipment
50 to 300 m² wet lab & office suites
Fully equipped with benches, sinks, pure water,
autoclave, freezers, …
Customized spaces / specific demand and layout
300 to m² wet lab, L2 & office suites
Consortium INOLINK - 29 September 2010 6

7. Consortium INOLINK - 29 September 2010
A new hospital and a center for clinical and translational research
A new hospital is in construction on the Genopole campus
- The latest general hospital built in France
beds
- Opening scheduled for 2011
Genopole coordinates the setting
of a center for clinical and
translational research within
the new hospital
Consortium INOLINK - 29 September 2010 7

8. Consortium INOLINK - 29 September 2010
A team dedicated to facilitating creation and development of biotech companies
7 multidisciplinary dedicated project managers
Combining solid complementary backgrounds in pre-incubation, IP,
finance, company valuation, bus. development, fund raising, licensing, …
A network of external experts
Strategy, business development, legal matters, regulatory affairs, clinical
development,... .
Expert Committee
15 members from academic institutions, pharma industry or VCs.
Consortium INOLINK - 29 September 2010 8

9. Consortium INOLINK - 29 September 2010
Currently, 69 biotech companies and active projects …
LTK Pharma
Texcell
GlobalBio Energy
NanoBH
Consortium INOLINK - 29 September 2010

10. Consortium INOLINK - 29 September 2010
Biotech companies: fact sheet
67 biotech companies (2009)
224 M€ raised ( )
159,5 M€ revenues ( )
681 patents filed ( )
24 products in development (2009)
Consortium INOLINK - 29 September 2010 10

11. Consortium INOLINK - 29 September 2010
State of the art shared technical platforms and equipment
Platforms
- CERFE (animal facility) Bioinformatic annotation
- Imaging and preclinical evaluation DNAchips production
- Mass spectrometry platform (augmented reality and virtual environment)
Equipment
Transmission electron microscopy Atomic force microscope
Cell sorting station Plant DNA Microarray platform
LiquiChip Workstation NMR Workstation
Consortium INOLINK - 29 September 2010 11

12. Consortium INOLINK - 29 September 2010
GMP production centers for drugs of the future
GMP manufacturing centers for
Therapeutic proteins and MoAbs in mammalian cells
Therapeutic proteins in bacteria, yeast, plants
Viral vectors (Genethon)
Oligonucleotides (in collab. with Sigma Aldrich)
Enzymes and biocatalysis for industrial use
- Center for filling and packaging GMP products
- Laboratory to develop expression systems
Consortium INOLINK - 29 September 2010 12

13. Consortium INOLINK - 29 September 2010
An international network oriented to biotech companies
Genopole integrates and gives access to an international network
Network of international companies, pharma laboratories, bioincubators
and venture capital institutions.
Genopole is a member of several European consortia with European bioparks
BioLink (FP5) Oxford, Munich, Cagliari, Jerusalem, Cardiff
Natibs (FP6) Berlin, Barcelona, Karolinska, Tallinn, Tel Aviv, Inno
CEBR (FP6) Cambridge, Oxford, Berlin, Munich, Heidelberg, Barcelona, Uppsala, Tallinn, Lyon
BIO CT (FP7) Berlin, Barcelona, Turin, Oxford, Debrecen, Inno
Consortium INOLINK - 29 September 2010 13

14. Consortium INOLINK - 29 September 2010
BIO-CT
To identify appropriate Tools (human, technical and financial) in the partnering Bio-Regions likely to be shared in support to innovative biotech projects;
To deliver a Joint Action Plan and Business Plan for the maturation of innovative biotech projects by the sharing of regional Tools (human, technical and financial).
Consortium INOLINK - 29 September 2010 14

15. Consortium Members 7 members from 6 countries. 5 Bio-Clusters
Consortium INOLINK - 29 September 2010

16. I-PoC achievement: The “Early Stage Development”
Consist in achieving a Project Maturation, from Research to Industry
Wet or Dry, but always Tough
Quotation from Branscomb, Auerswald & Al. Harvard and Georges Mason Universities
Consortium INOLINK - 29 September 2010

17. Consortium INOLINK - 29 September 2010
The original scheme from the DoW
Consortium INOLINK - 29 September 2010

18. Three main Work Packages
Project maturation (WP leader: BioTop Berlin)
Company incubation or
“Molecule” incubation (Academic Pre-development)
Access to the Human resource and their mobility. (WP leader: BioCAT Barcelona)
Example: Could Bio-regions co-operate
in Reverse Brain Drain actions?
Access to first class facilities, (GMP, …), located in other Bio-Region.
(WP leader: BioPark Canavese - Torino)
Consortium INOLINK - 29 September 2010

19. Consortium INOLINK - 29 September 2010
Genopole Engineering
The Unit of Genopole dedicated to offering specialized high-value services and customized solutions to emerging Bio-regions and Bio-clusters located outside France.
Genopole Engineering relays on
An in-house team with first-hand experience and extensive track-records from over a decade on technology transfer, project maturation, company creation and early financing.
An extensive network of independent consulting experts and firms in technologies and biotechnology.
A network of independent firms offering services and products in the fields of biotechnology and health-care.
A close collaboration with the French governmental agencies and network involved in the promotion of innovation
Consortium INOLINK - 29 September 2010 19

20. Consortium INOLINK - 29 September 2010
Genopole Engineering – Offer (1)
Companies / start-ups
Incubation; maturation
Financing: seed money, venture capital
Education & training (tech transfer, entrepreneurship, running an incubator/biocluster)
Company organization, project management
Product development
Evaluation and analysis of corporate and business contracts
Advice on technology / company valuation
Market & competition analysis
Intellectual property analysis
Consortium INOLINK - 29 September 2010 20

21. Consortium INOLINK - 29 September 2010
Genopole Engineering – Offer (2)
Innovation, research and development
Identification, implementation, coordination of innovative research programs
Technical assessment on science/technology
Strategic advice
Technology valuation
Elaboration of development plans to capture innovative value
Market & competition analysis / Intellectual property analysis
Innovative research: Project engineering, management, execution, follow-up & audit
Networking and search of partners, resource management
Research programs for third parties 21
Consortium INOLINK - 29 September 2010

22. Consortium INOLINK - 29 September 2010
Genopole Engineering – Offer (3)
Infrastructures
Design, construction, setting, validation of Platforms and Facilities
HT screening, imaging, genotyping, sequencing, cell sorting, manufacturing plants (for proteins in eukaryotic or prokaryotic cells, for viruses, viral vectors or vaccines), Hospitals / Clinical research units, containment level Laboratories (L2, L3), animal facilities, QC labs
Equipment, installation and operations
Platforms/ facilities: Project engineering, management, execution, follow-up & audit
Resource management
Networking and search of partners and suppliers
Implementation of QA systems / Dossiers for Certification / Accreditation
Consortium INOLINK - 29 September 2010 22

23. Consortium INOLINK - 29 September 2010
Genopole Engineering - Pipeline
Saudi Arabia
Poland
Tunisia
Morocco
South Africa
Argentina
India
China
Colombia
Consortium INOLINK - 29 September 2010 23

24. Consortium INOLINK - 29 September 2010