1. MARIO NEGRI INSTITUTE:
First plenary meeting of the project HOME/2014/JDRU/AG/DRUG/7086
ENVIRONMENTAL
HEALTH SCIENCES
MARIO NEGRI INSTITUTE:
Goodmorning to everyone, in this short presentation i’m going to introduce the Mario Negri Institute, its activitie and the main research topic of the group leaded by Ettore Zuccato.
Riva Francesco
Nutrition Toxicology Lab
Milan, 29th February 2016

2. INSTITUTIONAL POLICY
INDEPENDENT OF GOVERNMENT, POLITICS, UNIVERSITY AND INDUSTRY
MULTIPLE SOURCES OF FINANCING, NO ONE AMOUNTING TO MORE THAN 10% OF THE ANNUAL BUDGET
NONE OF OUR RESEARCH RESULTS ARE PATENTED
PRIVATE ENTERPRISE SERVING PUBLIC INTERESTS
First plenary meeting of the project HOME/2014/JDRU/AG/DRUG/7086

3. LOCATIONS Mario Negri Institute, Milano Center for Rare Diseases
Aldo and Cele Daccò
Ranica (Bg)
Anna Maria Astori Bergamo (BG)
Today the institute has three location, the main in Milan, a second one in Bergamo and a clinical research center for rare disease in Ranica.
First plenary meeting of the project HOME/2014/JDRU/AG/DRUG/7086

4. international scientific journal 250 books more than 245.500 citations
PERSONNEL
20 in 1961
550 in 2016
PUBLICATIONS
13000 scintific articles on
international scientific journal
250 books
more than citations
First Mario Negri Institute in Milano
from the initial group of 20 people today the Institute has more than 500 employees and results of their activities are reported in over 13,000 publications and 250 books
First plenary meeting of the project HOME/2014/JDRU/AG/DRUG/7086

5. DEPARTMENTS BIOMEDICAL ENGINEERING EPIDEMIOLOGY MOLECULAR BIOCHEM.
AND PHARM.
MOLECULAR
MEDICINE
NEUROSCIENCE
The researchers' works is organized into 10 departments and the institute's main activities concern the medicine and pharmacology.
Indeed the main research areas are the battle against cancer, cardiovascular and kidney diseases, rare diseases, epidemiology and public health. 
Among theese departements the departement of Environmental health science works to investigate the presence of the contaminants in the environment and on the assessment of human exposure with related health risks.
ONCOLOGY
PUBLIC HEALTH
RENAL
MEDICINE
CARDIOVASCULAR
RESEARCH
ENVIRON.
HEALTH SCIENCES
First plenary meeting of the project HOME/2014/JDRU/AG/DRUG/7086

6. ENVIRONMENTAL HEALTH SCIENCE
DEPARTMENT OF
ENVIRONMENTAL HEALTH SCIENCE
Proteomics and Metabolomics.
Molecular epidemiology used to identified genetic and/or environmental
factor posing risk to human health.
Risk assessment related to atmospheric pollution, contamination
of soil, surface and ground waters.
Evaluation of risk associated with contamination performed
in vitro and in silico,
Development and application of analithycal method for
compounds of biological and environmental interest.
First plenary meeting of the project HOME/2014/JDRU/AG/DRUG/7086

7. Thermo Q-exactive Orbitrap
Thermo LTQ xl orbitrap
Thermo Q-exactive Orbitrap
Theese some of the instrument in our department...
AbSciex triple quad. 5500
Agilent 6550 ifunnel Q-TOF
First plenary meeting of the project HOME/2014/JDRU/AG/DRUG/7086

8. LAB OF NUTRITION TOXICOLOGY
MAIN ACTIVITIES:
Study the sources, presence, behavior, fate and effects
of emerging environmental contaminants.
Development and application of analytical methods
for compounds of environmental interests.
Estimate of the drug consumption in the population.
Chemical contaminants in food and human nutrition.
Into this departement The Laboratory of Ettore Zuccato studies the source and fate of emerging environmental contaminants such as pharmaceuticals, illicit drugs, personal care products developing analytical method for these pollutants. Other thopics are the study of human exposure to food contaminants including dioxines and PCBs.
First plenary meeting of the project HOME/2014/JDRU/AG/DRUG/7086

9. ENVIRONMENTAL BIOMARKERS UNIT
MAIN ACTIVITIES:
Wastewater based epidemiology.
Development of sewage biomarkers
to be measured in urban wastewater.
Evaluate human habits such as illicit drugs,
alcohol and nicotine use.
Assess human exposure to pesticides.
Together with the environmental biomarker unit, leaded by Sara Castiglioni, our working group focused the attention on the Wastewater based epidemiology. The project started with cocaine and its metabolites, their levels in wastewater revealed that cocaine consumption greatly exceeds officials estimates. The approach has been extended to include other common drug of abuse and its able to detect consumption changes in real time complementing survey method and describe more realistically the drug consumption phenomenon. Now this approach include also nicotine, alcohol and other emerging contaminants like pesticides and mycotoxins.
First plenary meeting of the project HOME/2014/JDRU/AG/DRUG/7086

10. WORKING GROUP Pharmaceuticals Environmental Risk Assessment
Illicit Drugs
Micotoxines
WW based epidemiology
Illicit Drugs
Nitrosammines
WW based epidemiology
Pesticides
WW based epidemiology
First plenary meeting of the project HOME/2014/JDRU/AG/DRUG/7086

11. MAIN RESEARCH PROJECTS
SEWPROF (Marie Curie ITN # ): A new paradigm in drug use and human
health risk assessment: Sewage profiling at the community level.
Cost Action ES1307: Sewage biomarkers analysis for community health assessment.
Aqua Drugs (National Agency for Drug Policy): “Estimates of drug use in the
population by analysis of wastewater.”
Cariplo Rif (Fondazione Cariplo): “Assessment of the environmental
distribution of a number of new emerging and unconventional pollutants, to guide
actions to protect the environment and in particular the surface and underground
water.”
Theese and other research activities were conducted within several projects, including a cost action on sewage biomarker analysis, a collaboration with the national Agency for Drug policy for the estimates of drug use in the population and a project whit the SEWPROF network.
First plenary meeting of the project HOME/2014/JDRU/AG/DRUG/7086

12. Thank you for your attention
First plenary meeting of the project HOME/2014/JDRU/AG/DRUG/7086