1. London (South) Comprehensive Local Research Network
Clare Gillott
Lead RM&G Manager

2. Agenda Background to NIHR and the CLRN CLRN funding
NIHR Coordinated System for gaining NHS Permission (NIHR CSP)
Dementia research

3. Overview of NIHR CRN PCRN CCRN 25 NIHR Clinical Comprehensive Research
6 TCRNs
Stroke, Cancer, Diabetes,
Mental Health,
Medicines for Children,
Dementias and
neurodegenerative
diseases
CCRN 25
Comprehensive
Clinical Research
Networks
NIHR Clinical
Research
Network
Coordinating
Centre
PCRN

4. Our Goals
To ensure all areas of healthcare can take part in clinical research
Remove barriers to research within the NHS
Streamline administrative procedures associated with regulation, governance, reporting and approvals
Strengthen research collaboration with industry

5. NIHR Clinical Research Network
Portfolio
Eligibility
Funded by peer reviewed open national competition or commercial
Of benefit to NHS
Advantages
Access to NHS Service Support
Access to set up support (CLRN, TCRN, PCRN)
Access to NIHR Coordinated System for gaining NHS permission (CSP)

6. CLRN funding allocation
Clinical Research Coordinating Centre allocates funding to CLRNs based on uploaded accrual to the NIHR Portfolio
L(S) CLRN allocates funding to member Trusts based on accrual uploads (70%) and # Studies (30%) – This is currently being re-modelled for 2011/12

7. Funding Flow 2010/11 NIHR CRN £258m L(S) CLRN £18m Member Trusts 10%
60%
20%
Institution costs HR
Finance
Estates
Facilities
Research Management & Governance
Service Support
Sessions for clinicians, nurses and other support staff
Routine service support
Key service Support
Imaging
Pharmacy
Research passport
CSP (R&D approval)
Costing
Study management

8. Open funding calls: CLRN Contingency funding available to support:
Salary costs for staff recruiting to CLRN portfolio studies which cannot be covered by any other sources (devolved CLRN funding via Trust R&D departments, research grants, Trust FSF allocations etc)
Existing NIHR faculty members who are “between grants”
Research-related time of NHS-employed administrative and secretarial staff that are supporting recruitment to CLRN portfolio studies

9. Service support costs for studies that commence in year and cannot be funded by R&D departments
Unforeseen in year costs where recruitment would fail without additional support.
More information and details on how to apply are on the London (South) CLRN website:

10. Coordinated System for Gaining NHS Permission (NIHR CSP)
The next initiative we are going to look at is CSP – the coordinated system for gaining NHS permission.
I’ve already mentioned this when talking about IRAS, so now we’ll look at what it actually involves and how it will help you in getting permission from NHS organisations (also called R&D approval) 10

11. NIHR CSP Benefits
Consistency – consistent and comprehensive set of NHS research governance checks
Speed – streamlining and rationalising processes to reduce NHS R&D approval times
Predictability – a single system for processing and reviewing applications for NHS permission, centrally coordinated and supported through NIHR Comprehensive Local Research Networks
These are the three key benefits of CSP.

12. CSP principles All instructions and submissions through IRAS
Study wide activity:
CI makes study wide submission through IRAS
Lead CLRN completes global governance
Documents and governance made available to all sites taking part in the study
Local activity:
Local PI makes local submission through IRAS, includes;
Signed SSI form
Localised PIS and consent forms
Research team CVs
Local site completes local governance

13. Global governance undertaken once for the whole study
Local governance undertaken at each site
Once global and local review complete site issues NHS Permission
Substantial amendments managed through the system – no need for PIs to submit to local R&D Offices
However it is still the sponsors responsibility to provide PI’s with documentation

14. London (South) CLRN CSP functionality devolved out to member trusts
Trust R&D Departments assume roles of Lead and Host CLRN contact
R&D Departments able to provide full advice on CSP and IRAS submission process
All documentation submitted to the R&D Department will be uploaded to CSP (including substantial amendments)
R&D Department responsible for undertaking governance checks within CSP and issuing NHS Permission

15. Dementia research:
Identified as the only priority area by the Government for 2011/12
In response to this the CLRN have:
Set up a Dementia Specialty group
Funded a dementia nurse to help with the set-up and delivery of Dementia studies
If interested in being part of the Dementia Specialty Group please contact the CLRN for meeting details

16. Any questions?