1. Effect of medicinal plants and traditional medicine in
wound healing
Presented: A.Negaresh

2. Process of wound healing
Traditional Medicine
Process of wound healing
Medicinal plants
Result of Research

3. What is traditional medicine?
WHO defines traditional medicine as including diverse health practices, approaches, knowledge and beliefs incorporating plant, animal, and/or mineral based medicines, spiritual therapies, manual techniques and exercises which can be used to maintain well-being, as well as to treat, diagnose or prevent illness.

4. Traditional and Complementary/ Alternative Medicine
Categories of TM/CAM
Main Popular System of TM/CAM
Traditional Chinese Medicine
Indian Ayurveda Medicine
Arabic Unani Medicine
Chiropractic

5. Wound Healing
Inflammation occurs when the damaged endothelial cells release cytokines that increase expression of integrands in circulating lymphocytes.
Histamine, serotonin, and kinins cause vessel contraction (thromboxane), decrease in blood loss, and act as chemotactic factors for neutrophils, the most abundant cells in the initial 24 hour period.
Proliferative phase occurs next, after the neutrophils have removed cellular debris and release further cytokines acting as attracting agents for macrophages.
Fibroblasts now migrate into the wound, and secrete collagen type.
Angiogenesis occurs by 48 hours.
The secretion of collagen, macrophage remodeling and secretion, and angiogenesis continues for up to 3 weeks.
The greatest increase in wound strength occurs during this phase.

6. Maturation phase is the final phase and starts from the 3rd week and continues for up to 9-12 months.
This is where collagen III is converted to collagen I, and the tensile strength continues to increase up to 80% of normal tissue.

7. Medicinal plants in wound healing
Centella asiatica
Aloe vera
Ginkgo Biloba
Aristolochia bracteolate

8. Centella asiatica Increased enzymatic and non enzymatic antioxidants
Fibroblast proliferation
Collagen synthesis
Angiogenesis

9. Aloe vera Epithelisation Collagenisation
Aloe, a native to Africa, is also known as “lily of the desert” or the plant of immortality. Its name was derived from the alloeh meaning “bitter” because of the bitter liquid found in its leaves. Egyptians recorded use of this herbal plant in treating burns, infections and parasites as early as 1500 B.C.. Its clear gel has a dramatic ability to heal wounds, ulcers and burns by forming a protective coating on the affected areas and speeding up the healing process. The fresh plant contains 96% of water and rest is essential oil, amino acids, minerals, vitamins, enzymes and glycoproteins. Various constituents of Aloe vera have been shown to have anti- inflammatory activity. They also stimulate wound healing. Some clinical reports suggest topical Aloe vera gel is useful in healing minor burns and that such application of the gel is harmless as hypersensitive reactions to it are rare. However, in some severe burns, aloe gel may actually impede healing

10. Ginkgo Biloba Epithelization Increase in blood fluidity
Increase antioxidant

11. Aristolochia bracteolate
Epithelization
Increase in skin breaking strength
Increased collagen level

12. Animal studies