0. Steve Holmes, PhD Director, Therapeutic Targets Kymab Limited

1. I am in the Biotechnology industry
Each gene
Can be translated
Into a specific
protein
DNA
Proteins are large
and complex
and carry out the body’s
functions
A code
Organised into genes
>30,000 in each of us
Most biological medicines
are PROTEINS 1

2. Biologics : Some of the Molecules used in Medicine
IgG Monoclonal Antibody
MW ca. 160,000
-Interferon
MW ca. 18,500
Aspirin MW 180
Insulin
MW ca. 6,000

3. Pharmaceutical Product Sales
Total Sales $Billion
Top 10 - Sales $Billion
By 2014 Biologics are expected to account for 75% ($50Bn) of the revenues from the top 10 best selling drugs
Five of the Top 10 are predicted to be monoclonal antibodies

4. Mechanism of Action of Monoclonal Antibodies
Monoclonal Antibody
Unique binding
function
Effector function

5. Clinical use of Monoclonal Antibodies
Rheumatoid Arthritis – Disease Reversal
Clinically Approved anti-TNF
Monoclonal Antibodies for RA
Remicade
Humira

6. A day in the life of Steve Holmes
Research ideas for monoclonal antibody therapy for Amyotrophic lateral sclerosis IP, literature and competition searches Review list of experts in field
Prepare for meeting with Contract Manufacturing Organisation
Attend antibody research group meeting
Attend management meeting
Telecon with Wellcome Trust
Prepare project plan for new monoclonal

7. Kymab: Therapeutic monoclonal antibody company Life cycle: idea to clinic
~8 years
Ideas
Research
Development
Late clinical
trials
Approval
Early clinical trials
What is my job in the cycle?
Ideas
Research
Development
What skills are required to do my job?
Immunology, biochemistry, molecular biology
Antibody generation, antibody engineering, cell line development and manufacturing
Disease biology expertise
Clinical trials
IP, Fund raising, Bus. Dev.
Years of experience
Track record

8. Disease biology expertise
Kymab: Therapeutic monoclonal antibody company Life cycle: idea to clinic
~8 years
Ideas
Research
Development
Late clinical
trials
Approval
Early clinical trials
What skills are required to do my job?
Immunology, biochemistry, molecular biology
How did I gain the skills?
Post-Doc (3 years) Assistant Professor (4 years) On job training
Antibody generation, engineering, cell line development and manufacturing
Disease biology expertise
Clinical trials
IP, Fund raising, Bus. Dev.
Years of experience
Track record

9. Disease biology expertise
Kymab: Therapeutic monoclonal antibody company Life cycle: idea to clinic
~8 years
Ideas
Research
Development
Late clinical
trials
Approval
Early clinical trials
What skills are required to do my job?
Immunology, biochemistry, molecular biology
How did I gain the skills?
Antibody generation, engineering, cell line development and manufacturing
Academia Biotech. and Pharma. industry
Disease biology expertise
Clinical trials
IP, Fund raising, Bus. Dev.
Years of experience
Track record

10. Disease biology expertise
Kymab: Therapeutic monoclonal antibody company Life cycle: idea to clinic
~8 years
Ideas
Research
Development
Late clinical
trials
Approval
Early clinical trials
What skills are required to do my job?
Immunology, biochemistry, molecular biology
How did I gain the skills?
Antibody generation, engineering, cell line development and manufacturing
Disease biology expertise
Academia Biotech. and Pharma. industry
Clinical trials
30+ Patents Publications
IP, Fund raising, Bus. Dev.
Years of experience
Track record

11. Disease biology expertise
Kymab: Therapeutic monoclonal antibody company Life cycle: idea to clinic
~8 years
Ideas
Research
Development
Late clinical
trials
Approval
Early clinical trials
What skills are required to do my job?
Immunology, biochemistry, molecular biology
How did I gain the skills?
Antibody generation, engineering, cell line development and manufacturing
Disease biology expertise
Clinical trials
Pharma and Biotech industry
IP, Fund raising, Bus. Dev.
Years of experience
Track record

12. Disease biology expertise
Kymab: Therapeutic monoclonal antibody company Life cycle: idea to clinic
~8 years
Ideas
Research
Development
Late clinical
trials
Approval
Early clinical trials
What skills are required to do my job?
Immunology, biochemistry, molecular biology
How did I gain the skills?
Antibody generation, engineering, cell line development and manufacturing
Disease biology expertise
Clinical trials
IP, Fund raising, Bus. Dev.
Biotech industry
30+ Patents, 60+ publications
Years of experience
Track record

13. Disease biology expertise
Kymab: Therapeutic monoclonal antibody company Life cycle: idea to clinic
~8 years
Ideas
Research
Development
Late clinical
trials
Approval
Early clinical trials
4 mAbs
Bosatria
What skills are required to do my job?
Immunology, biochemistry, molecular biology
How did I gain the skills?
Antibody generation, engineering, cell line development and manufacturing
Disease biology expertise
Clinical trials
IP, Fund raising, Bus. Dev.
Years of experience
30+ years
Monoclonal antibodies in clinical trials Domantis – sold to GSK for £230M
Track record

14. Biotechnology Industry Salary, Career path and career progression/promotion opportunities
BSc 0 – 4 years experience ~£18K - £35K PhD 0 – 4 years experience ~£20K - £50K
Career Path Science Career Career Opportunities Research Associate Marketing/Sales
Scientist Patent attorney
Senior Scientist Business Dev./CBO
Director CEO
CSO Consultant
Found own company