1. History of Peptic Ulcer Treatment

2. History of Peptic Ulcer Treatment - 1
In 1586, Marcellus Donatus of Mantua performs autopsies and describes gastric ulcers
In 1868, Kussmaul suggests using bismuth compounds, an antibacterial agent, to treat peptic ulcers
In 1906, Krienitz finds bacteria in the stomach of people with gastric cancer.
In 1915, Antacids are first recommended for the treatment of peptic ulcer disease (PUD
In 1951, Allende publishes a book describing the treatment of gastric ulcers with penicillin
In 1958, Lykoudis treated patients for peptic ulcer disease with antibiotics,
In 1964, Lykoudis presents his antibiotic treatment for PUD at a meeting of the Medico-Surgical Society
He is largely shunned by the medical establishment
In 1968, Lykoudis is fined 4,000 drachmas for treating PUD patients with his treatment, which includes antibiotics
In 1982, Helicobacter pylori was rediscovered by two Australian scientists, Robin Warren and Barry J. Marshall as a causative factor for ulcers.
The H. pylori hypothesis was poorly received

3. History of Peptic Ulcer Treatment - 2
In 1983
Gastroenterological Society of Australia rejects Marshall's abstract to present his research at their yearly conference. They deem it in the bottom 10% of papers submitted.
Groups around the world begin isolating H. pylori
In 1984
Marshall intentionally consumes H. pylori and becomes ill. He takes antibiotics and is relieved of his symptoms.
The New York Times publishes an article by its medical correspondent Dr. Lawrence K. Altman on the possible link between H. pylori and PUD.[42] He states in 2002, "I’ve never seen the medical community more defensive or more critical of a story" since he joined the newspaper in 1969
In 1994, A conference held by National Institute of Health (USA) demonstrates the general acceptance of H. pylori as cause of PUD in the US.
In 1997, the Centers for Disease Control and Prevention, with other government agencies, academic institutions, and industry, launched a national education campaign to inform health care providers and consumers about the link between H. pylori and ulcers.
In 2005, Nobel Prize in Physiology or Medicine to Dr. Marshall and his long-time collaborator Dr. Warren "for their discovery of the bacterium Helicobacter pylori and its role in gastritis and peptic ulcer disease."