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Metabolism of ganglioside GM2 in GM2 activator-deficient fibroblasts

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1 Metabolism of ganglioside GM2 in GM2 activator-deficient fibroblasts
Metabolism of ganglioside GM2 in GM2 activator-deficient fibroblasts. [3H]Ganglioside GM2 was added to the culture medium of skin fibroblasts. After 70 h, the lipids were extracted, separated on thin-layer chromatography plates and the radioactive spots visualized with fluorography. Lane 1 = standards; lane 2 = normal control cells; lane 3 = GM2 activator-deficient cells, 30 μg of purified GM2 activator protein added with the ganglioside substrate. Source: The GM2 Gangliosidoses, The Online Metabolic and Molecular Bases of Inherited Disease Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular Bases of Inherited Disease; 2014 Available at: Accessed: September 27, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved

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