1. Development and regression of intimal thickening of arterially transplanted autologous vein grafts in dogs 
Kazumasa Morinaga, M.D., Hiroshi Eguchi, M.D., Taizo Miyazaki, M.D., Kenichiro Okadome, M.D., Keizo Sugimachi, M.D., F.A.C.S. 
Journal of Vascular Surgery 
Volume 5, Issue 5, Pages (May 1987)
DOI: / (87)
Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

2. Fig. 1
Depiction of model for distal poor runoff in canine femoral artery. a = superficial circumflex iliac artery; b = lateral circumflex femoral artery; c = distal caudal femoral artery; d = popliteal artery; e = femoral artery.
Journal of Vascular Surgery 1987 5, DOI: ( / (87) )
Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

3. Fig. 2 Experimental course of dogs in groups I and II.
Journal of Vascular Surgery 1987 5, DOI: ( / (87) )
Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

4. Fig. 3
Progression of intimal thickening in group I. N = number of grafts at each time interval. ○——○ = abnormal flow; ▵——▵ = normal flow.
Journal of Vascular Surgery 1987 5, DOI: ( / (87) )
Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

5. Fig. 4
Regression of thickened intima in group II. N = number of grafts at each time interval; ○——○ = normal flow; ▵——▵ = abnormal flow;
Journal of Vascular Surgery 1987 5, DOI: ( / (87) )
Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

6. Fig. 5
Microscopic features of autologous vein graft 3 days after implantation. a and c = abnormal flow; b and d = normal flow. (a and b, Hematoxylin-eosin stain, magnifications, × 71; c and d, ×710.)
Journal of Vascular Surgery 1987 5, DOI: ( / (87) )
Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

7. Fig. 6
Microscopic features of autologous vein graft 14 days after implantation. a and c, Abnormal flow; b and d, normal flow. Intimal thickening was greater in abnormal flow condition (a) than in normal flow condition (b). Thickened intima was composed of proliferation of smooth muscle cells (c). I = intima. (a and b, elastic van Gieson stain, magnification, × 71; c and d, hematoxylin-eosin stain, magnification, × 710.)
Journal of Vascular Surgery 1987 5, DOI: ( / (87) )
Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

8. Fig. 7
Microscopic figures of autologous vein graft 1 month and 8 months after implantation. a and b, Abnormal flow (1 month); c, abnormal flow (8 months); d, normal flow (8 months). Intimal thickening was more extensive in cases with abnormal flow (c) than with normal flow conditions (d). Thickened intima was composed of proliferated smooth muscle cells with rich intercellular fibrous stroma (b). I = intima; M = media. (a, c, and d, elastic van Gieson stain, magnification, ×71; b, hematoxylin-eosin stain, magnification, × 710.)
Journal of Vascular Surgery 1987 5, DOI: ( / (87) )
Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

9. Fig. 8
Microscopic features of autologous vein graft at 14 days (a and b) and at 1 month (c and d) after reimplantation to normal flow condition. I = intima; M = media. (a and c, elastic van Gieson stain, magnification, × 71; b and d, hematoxylin-eosin stain, magnification, × 710.)
Journal of Vascular Surgery 1987 5, DOI: ( / (87) )
Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

10. Fig. 9
Microscopic features of autologous vein graft 1 month (a and b) after reimplantation to abnormal flow condition and 8 months (c and d) after reimplantation to normal flow condition. I = intima; M = media. (a, hematoxylin-eosin stain, magnification, ×71; c, elastic van Gieson stain, magnification, × 71; b and d, hematoxylin-eosin stain, magnification, × 710.)
Journal of Vascular Surgery 1987 5, DOI: ( / (87) )
Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

11. Fig. 10
Electron microscopic features of superficial (a) and deeper (b) zones of thickened intima 1 month after implantation under abnormal flow conditions. L = lumen; SMC = transformed smooth muscle cells; MF = myofibrillae; CF = collagen fibers. (a, magnification, × 5300; b, × 10,000.)
Journal of Vascular Surgery 1987 5, DOI: ( / (87) )
Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

12. Fig. 11
Electron microscopic features of intima 14 days after reimplantation under normal flow conditions. EC = endothelial cell; SMC = smooth muscle cell (magnification, × 6600).
Journal of Vascular Surgery 1987 5, DOI: ( / (87) )
Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions