1. Supporting the advancement of biodefense and infectious disease research

2. Mission
SUPPORT BASIC RESEARCH TO DEVELOP DRUGS, DIAGNOSTICS, AND VACCINES FOR EMERGING AND REEMERGING INFECTIONS AND BIODEFENSE.
The Duke RBL supports sponsored research programs in the areas of:
Safety and Biopreparedness
Vaccine/Therapeutic Development
Host Response / Immune Monitoring
Proficiency Testing / Quality Assurance
Excess research support capacity in the RBL is available to investigators through the collaborative shared research units.

3. Units
The Duke RBL provides customized full or partial support to meet your animal model and laboratory study needs. Request services or an estimate through coreresearch.duke.edu, or contact us to discuss your specific needs.
The Duke RBL is fully approved for BSL3 and CDC select agent research.
The RBL has six fully-equipped 800 ft2 BSL2 lab suites, seven 180 ft2 BSL3 lab suites, and a 250 ft2 BSL2/3 cell sorting suite with a BD FACS Aria II.
The RBL also has two animal BSL2/3 suites, each with a procedure room and two animal holding areas (mouse, rabbit, ferret).
The RBL vivarium is also equipped with two aerobiology exposure systems and IVIS live animal imaging.

4. Leadership
THE DUKE RBL IS A DIVISION OF THE DUKE HUMAN VACCINE INSTITUTE, DUKE SCHOOL OF MEDICINE
Gregory D. Sempowski, PhD
Director
Scott Alderman, MS
Associate Director for Safety
and Operations
Heather E. Lynch, PhD
Assistant Director for Program
Management and Development

5. Services Andrew Macintyre, PhD Unit Manager 919.668.4704
Services
Commercial Luminex biomarker assays
Sample preparation (small animal, human, NHP)
Histopathology and immunophenotyping
ELISA (commercial, custom antigen specific)
Molecular assays (sjTREC, PCR arrays,TCR sequencing)
Core Research Code: D-0002

6. Services Rose Asrican, MS Unit Coordinator 919.681.5480
Services
Quality-controlled stock propagation
Mouse challenge models for plague, TB, tularemia, Cryptococcus, and others
Specializing in whole body aerosol exposure
MIC screening and FCU/IFU assays
Core Research Code: D-0045

7. Services Charles E. McGee, PhD Unit Manager 919.681.9824
Services
Quality-controlled stock propagation
Viral load quantification
Virus serology assays (HAI, PRNT, microneutralization)
Small animal challenge models for influenza, West Nile, Zika, and others
Core Research Code: D-0031

8. Contact Global Heath Research Building 909 S. LaSalle St.,
Durham, NC 27710
Phone:
The Duke Regional Biocontainment Laboratory (RBL) was built with funding from the NIH (UC6-AI58607)