1. “Stronger Together We are”
Daniel J. Sargent, PhD
I have the distinct honor and privilege to review Dan’s academic and professional career. I am deeply humbled to do this.
“Stronger Together We are”

2. Wore Many hats… Section Head, Cancer Center Statistics, Mayo Clinic
Chair, Division of Biomedical Statistics and Informatics
Director, Biostatistics Shared Resource for the Mayo Clinic Cancer Center
Group Statistician, Statistics and Data Center-
Alliance for Clinical Trials in Oncology ( )
North Central Cancer Treatment Group (2000 – 2010)
PI on multiple federal, industry, and foundation awards

3. Academic Credentials
Ralph S. and Beverley E. Caulkins Professor of Cancer Research at Mayo Clinic
Professor of Biostatistics – Mayo Clinic College of Medicine
Professor of Oncology – Mayo Clinic College of Medicine
Adjunct Professor:
Department of Biostatistics, University of Iowa
Division of Biostatistics, University of Minnesota
Department of Biostatistics & Bioinformatics, Duke University Medical Center

4. Education University of Minnesota – BS, Mathematics -1992
University of Minnesota – MS, Biostatistics -1994
University of Minnesota – PhD, Biostatistics -1996

5. Tenure at MAYO
1993: Intern Data Analyst – Division of Biostatistics, Mayo Clinic
1996: Research Associate – Cancer Center Statistics
1999: Associate Consultant – Cancer Center Statistics
2001: Senior Associate Consultant – Mayo Clinic
2005: Consultant – Division of Biostatistics, Mayo Clinic

7. Professional Leadership
NIH/NCI
Member, Clinical Trial Design Task Force, Investigational Drug Steering Committee(2008 – present)
Co-Chair, CTWG Evaluation Subcommittee(2010 – 2012)
Co-Chair, EORTC Working Group on Clinical Trial Methodology for Trials Involving Correlative Science(2002 – 2005)
Chair, KRAS Mutant Committee, Colon Cancer Task Force (2008 – 2009)
Chair, Scientific Review Group Subcommittee H-Clinical Trials (2003 – 2005)
Chair/Member of 91 DMC’s

8. Professional Leadership
Society for Clinical Trials
President – 2014
Fellow, SCT
Member, Program Committee (2008 – 2010)
Chair, Constitution and Bylaws Taskforce (2007 – 2012)
American Society of Clinical Oncology
Member, Clinical Meaningful Outcomes Workgroup (2012 – 2014)
Member, Program Committee (2011)

9. Journal Editorial Responsibilities
Associate Editor, Chinese Clinical Oncology Journal (2013 –)
Editorial Board Member, European Journal of Cancer (2009 –)
Editorial Board Member, Oncologist (2010 –)

10. Educational activities
Teaching/Lectureship/Workshops
20 intramural
11 extramural
Mentorship
PhD Thesis – 4 individuals
Innumerable summer interns!

11. Academic Interests Clinical Trial Conduct and Methodology
Survival Analysis
Clinical Trials Design
Surrogate Endpoints
Patient Reported Outcomes

12. Publications and Presentations
Presentations: National/International/regional
136
309 Publications
33 First Author
96 Last Author
27 Book Chapters
4 First Author
23 Last Author
59 Letters, Editorials and Commentaries
13 First Author
32 Last Author
2 Book Reviews
2 First Author

13. Published in… Statistical Biometrics Statistics in Medicine
Clinical Trials
Clinical
New England Journal of Medicine
Journal of Clinical Oncology
Journal of the National Cancer Institute
JAMA

14. R01 CA (2014 – 2018)
Methodology for development, validation, and use of novel endpoints in oncology
Aim 1: Enhance model-based phase I designs with novel multivariate endpoints.
Aim 2: Develop new and improve existing methodology for patient-level and trial-level evaluation of surrogate endpoints in clinical trials.
Aim 3: Develop novel adaptive phase II and III clinical trial designs specifically utilizing multiple endpoints (including surrogate endpoints) in the presence of biomarkers.

16. Remembering Dan
“The first time I saw Dan, I thought I was seeing the first statistical child prodigy because he looked like he was about 12 years old. In fact, he was the usual age for a grad student, but he was wise far beyond his years.”
“Dan was immensely proud of his roots. He never hesitated in describing the hard work of his parents in supporting him as a child, and their family landscaping business. I stopped trying to one-up him with my tree identification efforts!”
“His children and wife were always part of his conversations with me. He once remarked that the one decision he regretted was waiting so long to start a family. He loved watching his children growing up – tennis, long-distance running and first dates.”

17. Remembering Dan
“Dan had a permanent smile and interminable enthusiasm. He was a brilliant scientist, and he was so….alive!”
“Dan’s remarkable legacy will carry on through decades of discoveries and advances in clinical translation... Moreover, he persists within each one of the numerous mentees inspired by him to pursue a life of research.”
“I have known a number of Nobel Prize winners, but only one person I would characterize as a genius: that person is Dan Sargent.”

18. On a personal note
Dan was a dear friend, and mentor, and helped shape my professional career. He was always there to support me through difficult times, personally and professionally. I will remember him forever for all the ideals and principles he has taught me. He always told me: opportunity never comes to the unprepared mind.

19. On a personal note
He believed in the teams he built. He was always ready to take on new challenges, and thrived on new opportunities and challenges as those difficult situations always brought out the best in him. He was a strong leader with unwavering faith in himself and everyone that was part of his group. He was respectful and graceful in all his decisions as a leader, and a very bright scientist. I will remember him fondly forever