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Fatimah Abdullah 6th year MS, KFU
Peptic Ulcer Fatimah Abdullah 6th year MS, KFU
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Objectives Definition. Pathophysiology. Etiology. Clinical Picture.
Management.
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Definition Break in the gastrointestinal mucosa exposed to the aggressive action of acid-peptic juices. Common sites are the first part of the duodenum and the lesser curve of the stomach.
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Pathophysiology The gastroduodenal mucosal integrity is determined by protective (defensive) & damaging (aggressive) factors.
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Mucosal damage erosions & ulcerations
Pathophysiology Bicarbonate Mucus layer Prostaglandins Mucosal blood flow Epithelial renewal Defensive Helicobacter pylori NSAIDs Pepsins Bile acids Smoking and alcohol Aggressive Mucosal damage erosions & ulcerations
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Etiology H. Pylori Infection NSAIDs Smoking & Alcohol
Acid Hypersecretion Stress Family History of PUD.
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Clinical Presentation
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Gastric ulcer Duodenal Ulcer middle age 50-60 Any age specially 30-40
More in male Sex Same Stress job eg. Manager Occupation Epi. Can radiate to back Epigastric , discomfort Pain Immediately after eating 2-3 hours after eating & midnight Onset Eating Hunger Agg.by
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Gastric ulcer Duodenal Ulcer Lying down or vomiting Eating Relived by
Few weeks 1-2 months Duration Common(to relieve the pain) Uncommon Vomiting Pt. afraid to eat Good Appetite Avoid fried food Good , eat to relieve the pain Diet wt. Loss No wt. loss Weight 60% 40% Hematemesis Melena
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Investigations Stool fecal occult blood. CBC CBL.
Rapid Urease test, urea breath test H. Pylori. Upper GI Endoscopy. Barium meal X-Ray.
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Any patient >50 y/o with new onset of symptoms
Investigations Any patient >50 y/o with new onset of symptoms In all patients with “Alarming symptoms” endoscopy is required. Dysphagia. Weight loss. Vomiting. Anorexia. Hematemesis or Melena.
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UGT Endoscopy
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Management Life Style Change. Medical. Surgical.
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Life style modification
Discontinue NSAIDs Smoking cessation. Alcohol cessation. Stress reduction.
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Medications Antacids H2-receptor blocking agents.
Proton pump inhibitors. Cytoprotective and antisecretory drugs. Antibiotics.
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Medications H. pylori Eradication Therapy: Triple therapy:
Proton pump inhibitor . 2 Antibiotics: Metronidazole + Clarithromycin. Clarithromycin + Amoxicillin. In some regimens, H2-receptor blockers, e.g. ranitidine, are used instead of PPI.
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surgical Reduce acid and pepsin secretion. Indications: Principle:
Failure of medical treatment. Development of complications High level of gastric secretion and combined duednal and gastric ulcer. Principle: Reduce acid and pepsin secretion.
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surgical Vagotomy: Truncal Vagotomy with drainage.
Highly selective Vagotomy. Combination of vagal denervation (vagotomy) + anterctomy.
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Vagotomy Truncal vagotomy with drainage:
Resect the major trunk of the vagus to the stomach this will lead to: Decrease acid and pepsin secretion. Impair antral motility and drainage. Two types of drainage: Pyloroplasty. Gastrojejnostomy.
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Pyloroplasty Drainage
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Gastrojejunostomy Drainage
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Vagotomy It is a parietal cells vagotomy.
Highly selective vagotomy: It is a parietal cells vagotomy. It can be done with or without drainage. It is done by cut a branch of vagus of the body and the fundus this will lead to decrease HCl production.
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Vagotomy Combination of vagotomy+ anterctomy:
Combination of vagal denervation & removal of the major area of gastric production.
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Gastrointestinal continuity is restored by gastroduodenal (Billroth 1) anastomosis OR gastrojejunal (Billroth 2) anastomosis.
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Vagotomy Complications Dehiscence. Stenosis of anastomosis. Bleeding.
Injury to neighbour tissues. Dumping syndrome
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Complications of Disease
Hemorrhage Perforation peptic ulcer Gastric outlet obstruction
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Thank you
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