Presentation is loading. Please wait.

Presentation is loading. Please wait.

Epidermal growth factor receptor (EGFR) mutations in NSCLC

Published byMalcolm Ryan Modified over 7 years ago

Similar presentations

Presentation on theme: "Epidermal growth factor receptor (EGFR) mutations in NSCLC"— Presentation transcript:

1 Epidermal growth factor receptor (EGFR) mutations in NSCLC
Epidermal growth factor receptor (EGFR) mutations in NSCLC. A cartoon representation of EGFR showing the distribution of exons in the epidermal growth factor (EGF) binding and tyrosine kinase domains. Exons 18 to 21 in the tyrosine kinase region where the relevant mutations are located are expanded and the most common mutations associated with drug sensitivity and drug resistance are shown. Source: Lung Cancer, Fishman's Pulmonary Diseases and Disorders, 5e Citation: Grippi MA, Elias JA, Fishman JA, Kotloff RM, Pack AI, Senior RM, Siegel MD. Fishman's Pulmonary Diseases and Disorders, 5e; 2015 Available at: Accessed: October 01, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved

Download ppt "Epidermal growth factor receptor (EGFR) mutations in NSCLC"

Similar presentations

© 2005 Prentice Hall Inc. / A Pearson Education Company / Upper Saddle River, New Jersey 07458 Lung Cancer and Gefitinib  Lung cancer statistics in the.

© 2005 Prentice Hall Inc. / A Pearson Education Company / Upper Saddle River, New Jersey Lung Cancer and Gefitinib  Lung cancer statistics in the.
EGFR exon 20 insertion mutations

EGFR exon 20 insertion mutations
Defining Epidermal Growth Factor Receptor exon 20 mutant sensitivity to tyrosine kinase inhibition Danny Rayes.

Defining Epidermal Growth Factor Receptor exon 20 mutant sensitivity to tyrosine kinase inhibition Danny Rayes.
Epidermal growth factor receptor tyrosine kinase inhibitors as initial therapy for non- small cell lung cancer: Focus on epidermal growth factor receptor.

Epidermal growth factor receptor tyrosine kinase inhibitors as initial therapy for non- small cell lung cancer: Focus on epidermal growth factor receptor.
Management of asthma exacerbations: emergency department and hospital-based treatment. (Adapted from National Asthma Education and Prevention Program.

Management of asthma exacerbations: emergency department and hospital-based treatment. (Adapted from National Asthma Education and Prevention Program.
Frances A Shepherd, MD, Rafael Rosell, MD  Journal of Thoracic Oncology 

Frances A Shepherd, MD, Rafael Rosell, MD  Journal of Thoracic Oncology 
Large cell undifferentiated carcinoma of lung

Large cell undifferentiated carcinoma of lung
(Copied with permission from: Latson, L. A. , & Prieto, L. R. (2007)

(Copied with permission from: Latson, L. A. , & Prieto, L. R. (2007)
Defining Epidermal Growth Factor Receptor exon 20 mutant sensitivity to tyrosine kinase inhibition Danny Rayes.

Defining Epidermal Growth Factor Receptor exon 20 mutant sensitivity to tyrosine kinase inhibition Danny Rayes.
Figure 1. Resistance mechanism against first generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). (A) Mutations in the EGFR.

Figure 1. Resistance mechanism against first generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). (A) Mutations in the EGFR.
Fig. 2. High-resolution melting curves for exon 21 of the EGFR gene

Fig. 2. High-resolution melting curves for exon 21 of the EGFR gene
Nine patterns of inflammatory skin disease. (See also Table 8–1.)

Nine patterns of inflammatory skin disease. (See also Table 8–1.)
Diagnostic algorithm for normocytic anemia.

Diagnostic algorithm for normocytic anemia.
Stage IV non–small cell lung cancer (NSCLC)

Stage IV non–small cell lung cancer (NSCLC)
Hypothetical distribution of test results for healthy and diseased individuals. The position of the cutoff point between normal and abnormal (or.

Hypothetical distribution of test results for healthy and diseased individuals. The position of the "cutoff point" between "normal" and "abnormal" (or.
Structures of antiestrogens and aromatase inhibitors

Structures of antiestrogens and aromatase inhibitors
Prognostic and Predictive Value of Epidermal Growth Factor Receptor Tyrosine Kinase Domain Mutation Status and Gene Copy Number for Adjuvant Chemotherapy.

Prognostic and Predictive Value of Epidermal Growth Factor Receptor Tyrosine Kinase Domain Mutation Status and Gene Copy Number for Adjuvant Chemotherapy.
Schematic comparison of structural features of cell surface growth factor receptor tyrosine kinases and membrane-associated tyrosine kinase oncogene products.

Schematic comparison of structural features of cell surface growth factor receptor tyrosine kinases and membrane-associated tyrosine kinase oncogene products.
Radiation-induced pulmonary fibrosis

Radiation-induced pulmonary fibrosis
Average annual number of dengue fever/dengue hemorrhagic fever cases reported to the World Health Organization and average annual number of countries reporting.

Average annual number of dengue fever/dengue hemorrhagic fever cases reported to the World Health Organization and average annual number of countries reporting.

Similar presentations

Ads by Google