1. Genetic and Prognostic Differences of Non-small Cell Lung Cancer between Elderly Patients and Younger Counterparts
Kenichi Suda 1 ;Kenji Tomizawa 2 ;Hiroshi Mizuuchi 1, 4 ;Simon Ito 2 ;Hirokazu Kitahara 1 ;Shinichiro Shimamatsu 1 ;Mikihiro Kohno 1 ;Tsukihisa Yoshida 1 ;Tatsuro Okamoto 1 ;Yoshihiko Maehara 1 ;Yasushi Yatabe 3 ;Tetsuya Mitsudomi 4 ;
1 Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka; ; 2 Departments of Thoracic Surgery and ; 3 Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya; ; 4 Division of Thoracic Surgery, Department of Surgery, Kinki University Faculty of Medicine, Osaka-Sayama, Japan ;
Figure 1 Representative analytic method for somatic mutations in the EGFR gene and the ALK translocation. a Sequencing chromatogram for EGFR exon 21 shows CTG leucine to CGG arginine substitution yellow arrow, which results in the L858R mutation. b Break-apart FISH assay for ALK. Red and green probes are designed for both sides of the ALK gene break point. A yellow signal mixed signal indicates wild type allele; separated red and green probe signals indicate the rearranged ALK.
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