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A long-term survivor of non-small-cell lung cancer harboring concomitant EGFR mutation and ALK translocation  Fumio Imamura, Takako Inoue, Madoka Kimura,

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Presentation on theme: "A long-term survivor of non-small-cell lung cancer harboring concomitant EGFR mutation and ALK translocation  Fumio Imamura, Takako Inoue, Madoka Kimura,"— Presentation transcript:

1 A long-term survivor of non-small-cell lung cancer harboring concomitant EGFR mutation and ALK translocation  Fumio Imamura, Takako Inoue, Madoka Kimura, Kazumi Nishino, Toru Kumagai  Respiratory Medicine Case Reports  Volume 19, Pages (January 2016) DOI: /j.rmcr Copyright © 2016 The Authors Terms and Conditions

2 Fig. 1 Treatment history with an EGFR-TKI and ALK-TKIs. The vertical axis showed serum CEA values. Arrows indicated by A and B in the upper half show the time when CT images A and B in Fig. 2 were obtained, respectively. The numbers in the lower half indicate the time when CT images with the corresponding number in Fig. 3 and 5 were obtained, respectively. An asterisk indicates a 3rd generation of EGFR-TKI. Respiratory Medicine Case Reports  , DOI: ( /j.rmcr ) Copyright © 2016 The Authors Terms and Conditions

3 Fig. 2 Chest CT images during the treatment with an EGFR-TKI. A) extensive disease progression throughout in the left thorax before the start of gefitinib, and B) remarkable regression of the disease was attained with gefitinib. Respiratory Medicine Case Reports  , DOI: ( /j.rmcr ) Copyright © 2016 The Authors Terms and Conditions

4 Fig. 3 Chest CT images during the treatment with ALK-TKIs and the combination of an EGFR-TKI with an ALK-TKI. Arrow heads in the right, central, and left column indicate the lesion in the left lung, a left axillar lymph node, and a metastatic lesion to the thoracic wall, respectively. Respiratory Medicine Case Reports  , DOI: ( /j.rmcr ) Copyright © 2016 The Authors Terms and Conditions

5 Fig. 4 Immunocytochemical staining with an ALK antibody (Roche D5F3F). Almost all cancer cells were positive for ALK. Respiratory Medicine Case Reports  , DOI: ( /j.rmcr ) Copyright © 2016 The Authors Terms and Conditions

6 Fig. 5 Chest CT images before (4) and during (5) the treatment with a 3rd generation EGFR-TKI. Each column corresponds to that in Fig. 3. Appreciable response was observed. Respiratory Medicine Case Reports  , DOI: ( /j.rmcr ) Copyright © 2016 The Authors Terms and Conditions

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