1. Laboratoire d’imagerie fonctionnelle et métabolique
LIFMET
Laboratoire d’imagerie fonctionnelle et métabolique
Prof. Rolf Gruetter
Orateur:
Guillaume Donati

2. What is Biochemical imaging?
Get informations from the interior of a living system
Reveal internal structure and/or metabolism without surgery
X-rays: Röntgen (1895)
CT : Hounsfield and Cormack (1970)
Echography : Wild and Reid (1951)
MRI : Lauterbur and Mansfield (1971)
PET (1950s)

3. Which disciplines are used?
Maxwell equations simulations
Mathematics
Photons-matter interactions
Engineering
Neuroscience
Physics
Build devices
What is measured
Spin resonance
Biochemistry
Medicine
Medical or research applications

4. Physics in LIFMET Physics of nuclear and electron spin (MRI-MRS):
(Quantum mechanics)
Small animal
9.4T scanner
Human 7T scanner
Small animal
14T scanner

5. Physics in LIFMET Positron emission tomography
(imaging anti-matter annihilation, Compton scattering) O HO OH γ
511 keV OH
18O-
18F
Fluorodeoxyglucose
Glucose
511 keV

6. Current projects

7. Motion correction using fat navigator

8. MRI of human heart
Difficult because the heart is always beating…

9. 13C MRS in human brain
Design and build a device to detect the 13C nuclei in the human brain

10. Glioblastoma (GBM) mouse xenografts derived from freshly injected human cells
Normal/healthy
Next challenges:
Analyze the longitudinal evolution of GBM and eventual differences between patients
Glioma/brain tumor
Contact:
Marta Lai:
Cristina Cudalbu:

12. Projets TP IV et master: voir www.cibm.ch (site anglais)
Impact of advanced image distortion correction on task and resting-state fMRI statistics
Characterization of resting state networks & artefacts obtained with 2D and 3D fMRI sequences at high field
High Sensitivity coil design for mouse/rat imaging at 9.4 /14 T
Optimized Representation of 3D RF Sensitivity Fields for human brain imaging
MR image quality at 7T in the presence of an EEG system
Etc…

13. Merci pour votre attention