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Clinical decision support genome informed cancer medicine
in the era of genome informed cancer medicine Mia Levy, MD, PhD Ingram Assistant Professor of Cancer Research Director Cancer Health Informatics and Strategy Assistant Professor of Biomedical Informatics Assistant Professor of Medicine, Division of Hematology and Oncology Vanderbilt University May 25, 2016
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Notice of Faculty Disclosure
In accordance with ACCME guidelines, any individual in a position to influence and/or control the content of this ASCP CME activity has disclosed all relevant financial relationships within the past 12 months with commercial interests that provide products and/or services related to the content of this CME activity. The individual below has disclosed the following financial relationship(s) with commercial interest(s): Mia Levy, MD, PhD Personalis Genomoncology Advisory Board fee Consultant fee Executive Scientific Advisory Board Consultant
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Cancer Care Continuum Risk Assessment, Reduction & Screening Diagnosis
Treatment Selection Treatment Plan Management Host & Disease Response Assessment
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Biomarkers in the Cancer Care Continuum
Risk Assessment, Reduction & Screening Diagnosis Treatment Selection Treatment Plan Management Host & Disease Response Assessment Risk Biomarker Diagnostic Biomarker Prognostic Biomarkers Predictive Biomarkers Response Biomarker BRCA1/2 Estrogen Receptor OncotypeDx Supportive Care Pharmacogenomics Tumor Burden Predictive Biomarkers Tumor Resistance Estrogen Receptor Host Toxicity CYP2D6
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Decision Support Cancer Care Continuum
Risk Assessment, Reduction & Screening Diagnosis Treatment Selection Treatment Plan Management Host & Disease Response Assessment Predictive Biomarkers Types of Decision Support: Which tests to order? How to interpret and report results? How to apply results to patient care? Mode of Decision Support: When How To Whom
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Unselected Population
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Treat Unselected Response No Response
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2002 Comparison of 4 Chemotherapy Regimens in Advanced Lung Cancer
Response rate – 19% Median TTP – 3.7 mos Median OS – 8 mos 1207 pts Schiller et al, NEJM ‘02
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EGFR mutated lung cancer
2009 EGFR mutated lung cancer Initial phase III first line EGFR TKI trial: “IPASS” EGFR TKI vs. Carboplatin - Paclitaxel in Never- or Light Ex-Smokers Ref: Mok et al NEJM 2009; updated data Fukuouka et al JCO 2011 Mok TS, et al. N Engl J Med. 2009;361(10):
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Unselected Population
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Predict Treatment Efficacy
Selected Population Predictive Biomarker Predict Treatment Efficacy Informs Drug Selection
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Treat Selected Targeted Therapy Primary Sensitivity Primary Resistance
Disease Progress Acquired Resistance
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Riding the Tsunami of Genomic Data
Evolution of testing strategies Single mutation -> Hot spot panels -> NGS
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Levels of Evidence Pre-clinical Clinical Validity Clinical Utility
Retrospective Cohort Studies Non-randomized Prospective Studies Randomized Prospective Studies Guidelines Animal Models Cell Lines Case Reports Pre-clinical Clinical Validity Clinical Utility Separates one population into two or more groups with distinctly different outcomes Incorporated into standard of care clinical decision making
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Non-small cell lung cancer
2016 Non-small cell lung cancer Molecular alteration Drugs Level of evidence EGFR mutation erlotinib, gefitinib, afatinib FDA approved ALK rearrangements crizotinib, ceritinib EGFR T790M mutation osimertrinib PD-L1 expression pembrolizumab BRAF mutation Trametinib, dabrafenib ROS1 rearrangements crizotinib MET amplifications NCCN HER2 mutations trastuzumab, afatinib KRAS mutations Resistance to TKI’s Mok TS, et al. N Engl J Med. 2009;361(10):
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Mission of My Cancer Genome
To curate and disseminate knowledge regarding the clinical significance of genomic alterations in cancer
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Content Dissemination
My Cancer Genome Content Generation Content Dissemination
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Manually Curated Content
21 Cancers ALL ALCL AML CML MDS GIST IMT Breast Glioma Gastric Lung Colorectal Basal Cell Carcinoma Bladder Medulloblastoma Melanoma Neuroblastoma Ovarian Rhabdomyosarcoma Thymic Thyroid 20 Pathways 823 Genes 21 Cancers 429 Variants 552 Drugs
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Location of Alteration in Gene
Levels of Evidence FDA Approvals Guidelines Published clinical trial results Retrospective cohort analysis Case Reports Clinical trial eligibility criteria Pre-clinical studies Frequency of Alteration in Disease Response to Drug Sensitivity/Resistance
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Biomarker Classification & Prioritization
Variants High Priority Type of effect Sensitivity Size of effect Resistance Prognostic Diagnostic Strength of evidence Clinical Validity Clinical Utility JCO, Levy 2013
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Biomarker Representation
Types of Biomarkers Gene Variant (point mutations, insertions, deletions) Exon Fusions/Rearrangements Gene Amplification Protein Expression Logical Combinations of Alterations AND/OR/NOT
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Therapy Assertion Lung Cancer & Erlotinib (single alteration)
EGFR L858R mutation Response: Primary Sensitivity Line of Therapy: Metastatic
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Therapy Assertions Lung Cancer & Erlotinib (co-occuring alterations)
EGFR L858R mutation EGFR T790M mutation AND Response: Acquired Resistance Line of Therapy: Metastatic
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Therapy Assertion Colon Cancer & Cetuximab (Alteration NOT detected in Variant Group)
KRAS Exon 2, 3, or 4 mutation NRAS Exon 2, 3, or 4 mutation AND NOT DETECTED NOT DETECTED Response: Primary Sensitivity Line of Therapy: Metastatic Source: FDA (KRAS Exon 2) Source: NCCN (KRAS Exon 2, 3, 4) Source: ASCO (KRAS Exon 2)
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Prognostic Assertion Acute Myeloid Leukemia (single alteration)
Karyotype Normal Prognosis: Indeterminate Source: NCCN
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Prognostic Assertion Acute Myeloid Leukemia (co-occuring alterations)
Karyotype Normal NPM1 Exon 11 Mutation AND Prognosis: Favorable Source: NCCN
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Prognostic Assertion Acute Myeloid Leukemia (co-occuring alterations)
Karyotype Normal NPM1 Exon 11 Mutation AND FLT3 ITD Detected Prognosis: Unfavorable Source: NCCN
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Clinical Trial Annotation
Arm 1 Disease Group(s) Biomarker Group(s) Include Exclude Arm 2 Arm 3 Include Exclude Arm n
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Example: NCI Match NCI Match Disease Group(s) Biomarker Group(s) Arm G
Include: Solid Tumor Lymphoma Include: BRAF V600E/K/R/D Mutation Arm H Arm U Exclude: Melanoma Colorectal & Papillary Thyroid Cancer Exclude: KRAS, NRAS, HRAS mutations Arm B Arm R Arm n
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Curation: Disease & Biomarkers Criteria
Linking Text in Primary Document to Annotation
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Content Growth 8 968 genes variants diagnosis variant drug sensitivity
(FDA) diagnosis variant drug sensitivity (experimental)
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Contributor Network
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Core Team Mia Levy, MD, PhD Co-editor in-chief
Christine Lovly, MD, PhD Christine M. Micheel, PhD
Managing Editor Kate Mittendorf, PhD Research Analyst Ingrid A. Anderson, PhD
Program Coordinator This is My Cancer Genome’s core team. Mia Levy and Christine Lovly are the co-editors in chief, I am the managing editor, and Ingrid Anderson and Kate Mittendorf make up the rest of the content team.
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Worldwide Collaboration
68 Contributors 26 Institutions 10 Countries 4 Continents
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Content Dissemination
My Cancer Genome Content Generation Content Dissemination
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Publically Available Resources Clinically Integrated Solutions
Dissemination Publically Available Resources Clinically Integrated Solutions Website >2.5M page views, 201 countries Vanderbilt EHR >5800 patients My Cancer Genome Laboratory Reporting Tool >3200 specimens Mobile App >3634 Downloads, 22K sessions
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New Method for Reporting Mutation Results in the EHR
R = Outside Specimen Requested Order Status (letter) O = Order Received A = Outside Specimen Arrived v = Specimen Accessioned Yellow = Gene Mutation Detected Grey = Gene Mutation Not Detected Red = No Result – Insufficient Specimen Result Status (colored box) Levy, ASCO 2011 Levy, Genome Research 2012
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New Method for Reporting Mutation Results in the EHR
Levy, ASCO 2011 Levy, Genome Research 2012
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New Method for Reporting Mutation Results in the EHR
Primary Sensitivity Primary Resistance Secondary Resistance Levy, ASCO 2011 Levy, Genome Research 2012
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Next Generation Sequencing
Scale Reporting 1 Variant 1 Gene 40 Variants 6 Genes 1000s Variants 100s Genes Next Generation Sequencing Multi-modal testing
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Approach Use MyCancerGenome as a
Knowledge Base of clinically relevant variants for interpretation of NGS cancer panel Sequence Alignment Tumor/Normal Comparison Algorithm Molecular Annotation of Variants Reference Sequence Known Variants Knowledge Bases Genome Testing Modality Variant Identification Clinical Interpretation of Variant Clinical Decision Variant-clinical effect knowledge bases Report Actionable Results & VUS Classify clinical effect of variant(s) JCO, Levy 2013
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Decision Support for Variant Analysis
Actionable for Tumor Type Actionable for Other Tumor Type Not Actionable
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Decision Support for Variant Interpretation & Reporting
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Decision Support for Variant Interpretation & Reporting
Variants with Potential Clinical Utility Drug Sensitivity In Disease (Level 1) In Other Disease (Level 2)
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Decision Support for Variant Interpretation & Reporting
Potential Clinical Trials (Level 3)
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Detailed Summary of Alteration In Disease
Content from My Cancer Genome Link to MyCancerGenome.org
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Trial Matching Decision Support
861 cases with NGS testing at Vanderbilt 36% potential match NCI Match 21 trial arms Model disease and biomarker eligibility for the 10 (20) arms of NCI match trial 900 patients with solid tumor or lymphoma and NGS data (FoundationOne)( ) (average X variants per case) X% patients potentially match at least one arm, X% more than one arm Next steps, extend trial annotation and develop a clinical workflow for notification Average 4.4 variants per patient Min Date of Collection: 7/3/2000 Max Date of Collection: 9/23/2015 Min Specimen Received: 8/29/2012 Max Specimen Received: 10/07/2015 Next Steps: Extend trial annotation & integrate algorithm into clinical workflow
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Challenges & Future Directions
My Cancer Genome Content Generation Content Dissemination
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Small Sub-populations
Targeted Therapy Primary Sensitivity Primary Resistance Acquired Resistance
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Only 5% of cancer patients participate in clinical trials
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Learning Cancer System
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Learning Cancer System
Outcomes Treatment Selection Population Analysis
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Many Are Looking at Different Parts of the Same Problem
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President Obama’s State of the Union Address pushes for precision medicine
2015 – 1 Million person precision medicine cohort 2016 – Moonshot to “cure” cancer (Biden named “Cancer Czar”
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Evolution of Clinical Decision Support
Evidence Driven Protocol Driven Pathway Driven Data Driven?
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Summary Rise of genomic profiling in cancer
My Cancer Genome knowledge base provides decision support for clinical utility of alterations in cancer Strategies for content generation and dissemination Strategies for clinical decision support
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Acknowledgements Mia Levy Christine Lovly Christine Micheel Ingrid Anderson Kate Mittendorf Scott Sobecki Joey Schneider Mik Cantrell Daniel Carbone Ross Oreto Melissa Stamm Lucy Wang Danny Wenner Mikhail Zemmel Nunzia Giuse Taneya Koonce Sheila Kusnoor John Clark Katy Justiss Batia Karabel Patricia Lee Helen Naylor Tracy Shields Hassan Naqvi MCG Contributors MCG Alumni And many more… But, the team that makes My Cancer Genome happen is much larger. This slide shows just a few of the many amazing people who make My Cancer Genome a reality. This is the development team responsible for the website and mobile apps. And this is the knowledge management team we collaborate with on several research projects. And we thank our contributors, all the alumni, and everyone else who has contributed to My Cancer Genome.
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Thank You mia.levy@vanderbilt.edu
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