1. UNYTE Translational Research Network R. C. Block MD1, T
UNYTE Translational Research Network R.C. Block MD1, T. Fogg MS, MPH1, F. S. Kaufman, BA2, G.D. Morse, PharmD2, T. Pearson MD, MPH, PhD1 1University or Rochester Medical Center – Clinical and Translational Science Institute; 2University at Buffalo – NYS Center of Excellence in Bioinformatics and Life Sciences
Rochester Institute of Technology
Bio-X builds on RIT's core technical strengths to address biological, health-care, and medical challenges
National Technical Institute for the Deaf
Lab for Environmental Computing and Decision Making
Policy and economic impacts of health issues
NY Chiropractic College
Biomechanics Laboratory
Neuromuscular Research Laboratory
Roswell Park Cancer Institute
NCI-designated comprehensive cancer center
Center for Pharmacology and Therapeutics
University at Buffalo
Center for Computational Research
Center of Excellence in Bioinformatics and Life Sciences
Institute for Healthcare Informatics
Center for Unified Biometrics and Sensors
Center for Advanced Photonics & Electronic Materials
Guthrie Health System
Guthrie Practice Based Research Network
Guthrie Research Institute
Cardiovascular Disease clinical trials
Oncology clinical trials
Syracuse University
Syracuse Biomaterials Institute (SBI)
Aging Studies Institute
Center of Excellence in Environmental and Energy Systems
Cornell University
Human Metabolic Research Unit
Cornell Institute for Nutritional Genomics
Binghamton University
Center for Advanced Information Technologies
Center for Applied Community Research and Development
Center for Development and Behavioral Neuroscience
Clinical Science and Engineering Research Center
Trudeau Institute
Research Emphasis: Influenza, Tuberculosis, Tropical Diseases, Sepsis & Coagulation, The Aging Immune System, Cancer Immunology
SUNY Albany
Gen*NY*Sis Center for Excellence in Cancer Genomics
Center for Neuroscience Research
The RNA Institute
SUNY Upstate Medical University
Upstate Cancer Research Institute
Diabetes, Metabolic Disorders & Cardiovascular Disease; Disorders of the Nervous System; SUNY Eye Institute; Infectious Diseases & Emerging Pathogens
Clinical Research Unit
Masonic Medical Research Laboratory
Cardiovascular Research focused on genetics, mechanisms and treatments of cardiac arrhythmias.
Molecular Genetics; Molecular Biology; Cardiac electrophysiology and Induced Pluripotent Stem Cells
Bassett Healthcare Network, Research Institute
Divisions: Basic Science, Rural Community Health,
Clinical Research, and Biostatistics & Computing
Bassett School-Based Health Program
Occupational injury and illness; Behavior change
Community-based health interventions
Rensselaer Polytechnic Institute
Center for Biotechnology and Interdisciplinary studies
Computational Center for Nanotechnology Innovations
Upstate New York Shared Human Stem Cell Research Center
Scientific Computation Research Center
Albany Medical College
Four Interdisciplinary Research Centers; Cardiovascular Sciences, Cell Biology and Cancer Research, Immunology and Microbial Diseases; Neuropharmacology and Neuroscience
Industry-funded clinical research studies across multiple specialties conducted by Anesthesiology, Medicine, Neurology/Neurosciences, Pediatrics and Surgery
Albany College of Pharmacy
Pharmaceutical Research Institute
Research Institute for Health Outcomes
Special emphasis in infectious disease, sepsis, nephrology, GI, and health outcomes research.
Wadsworth Center, NYS DOH
NYS Reference Laboratory/ Public Health Research Center
Infectious Disease and Host Defense; Molecular Genetics and Genomics; Neuroscience; Molecular and Cellular Basis of Disease; Environmental Health Science
Special expertise in 3D electron microscopy, x-ray crystallography, brain computer interface, bioinformatics, biomonitoring
University of Rochester
Clinical and Translational Science Institute is one of the original 12 CTSAs
Clinical research through the Center for Human Experimental Therapeutics; Clinical Research Center; Center for Research Implementation and Translation and Center for Community Health
Clinical and Translational Science Building will serve as an institutional and regional hub for clinical and translational research
OVERVIEW
The University of Rochester Clinical and Translational Science Institute initiated the UNYTE Translational Research Network as a key function of its Clinical and Translational Sciences Award (CTSA). UNYTE is a consortium of biomedical research centers and academic research centers performing clinical and translational research within the Upstate New York and surrounding regions. The network utilizes a shared administrative leadership structure with the SUNY University at Buffalo New York State Center of Excellence in Bioinformatics and Life Sciences. It was the first CTSA Program to develop such a regional network. The goal of this key function is to further develop this model consortium as a “Regional Home for Translational Research” and foster scientific and economic growth.
UNYTE CTSA Pilot Award Program Awardees
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Recent Accomplishments
UNYTE has developed a novel web-based central inventory of the research resources available at each member institution in addition to core areas of expertise. The Research Resource Database enables investigators to facilitate collaboration among member institutions and identify necessary resources needed to successfully conduct proposed multi-institutional research.
UNYTE has also developed a custom NIH RePORTER Database of NIH funded grants and contracts awarded to UNYTE institutions. The Research Project Database is an on-line, searchable inventory of research projects that have taken place at UNYTE institutions. The information may help users find collaborators or mentors across UNYTE via the database’s fast and easy search tools.
YEAR
PROJECT TITLE
PI and INSTITUTION
CO-INVESTIGATOR and INSTITUTION
2010
The Upstate New York Network for Collaborative Biomedical Imaging
Axel W.E. Wismueller, MD, PhD (PI) Avice M. O'Connell, MD, (University of Rochester)
Andrzej Krol, PhD, Wei Lee, PhD
(Upstate Medical University)
Protein Kinase C Activation and Inhibition of VLDL Triglyceride Export Defines a Mechanism for Development of Non-Alcoholic Fatty Liver Disease
Janet Sparks, PhD (University of Rochester);
Michael Greene (Bassett Research Institute)
2011
Regional Stat Tumor Procurement to Support Studies of Lymphoma
Richard Burack, MD, PhD (University of Rochester)
Robert Hutchison, MD (SUNY Upstate);
Tipu Nazeer, MD (Albany Medical College Consultant)
2012
Validity of Self-Reported Data for Studying Cognitive Problems and Depression
Katia Noyes, PhD, MPH (University of Rochester)
Ralph Benedict, PhD (University of Buffalo);
Bianca Weinstock-Guttman, MD  (University at Buffalo)
Andrew Goodman, MD (University of Rochester);
Barbara Teter,  PhD (New York State Multiple Sclerosis Consortium Consultant);
2013
Regional Ultrasound Wall Strain Measurements to Predict Risk of Abdominal Aortic Aneurysm (AAA) rupture
Ankur Chandra, MD, RPVI (University of Rochester)
Karl Schwarz, MD (University of Rochester);
Steven Day, PhD (Rochester Institute of Technology);
Dan Phillips, PhD (Rochester Institute of Technology)
Determining the interplay of Lymphoma Cells with its Microenvironment using a Novel In vivo Model
Steven H. Bernstein, MD, (University of Rochester)
Richard Burack, MD, PhD(University of Rochester);
Shannon Hilchey, PhD (University of Rochester);
Richard Bankert, VMD, PhD (University at Buffalo)
Research Resource Database
Research Project Database
Administrative Structure
Federally Funded Multi-Institutional Grant Activities
Current Priorities and Future Direction
Continue to foster clinical and translational research collaboration among UNYTE institutions
Identify member institution needs that will promote training and expertise in clinical and translational research
Foster innovation among UNYTE institutions that will lead to novel clinical and translational research programs that are competitive for federal funding.
Maximize collaboration within the UNYTE geographic region that includes community-based patient organizations, industry partnerships and urban and rural health care settings.
Utilize information technology and communications systems to promote regionalization of scientific research that addresses the needs of patients in our communities.
TITLE
PI and COLLABORATORS
Rochester Bridges to the Doctorate (NIH R25)
Thomas Pearson, MD, MPH, PhD (co-PI UR)
Peter Hauser, Ph.D. (co-PI RIT)
Researcher Resilience through Multidimensional Mentoring-Pathfinder (NIH Director’s Office ARRA)
Vivian Lewis, MD (UR)
Collaborators: UB, SUNY Upstate
Genetic Risk of Neurocognitive Disorders in Patients with HIV Infection (NIH K08)
Qing Ma, PhD (UB)
Collaborators: UR, Vanderbilt
Fish Oil Effects on Cardiovascular Disease Risk in Diabetics (NIH R21)
Robert Block, MD, MPH (UR)
Collaborators: ACP, Cornell
Research technology U grant: CyTOF Mass Cytometer for Western NY
Tim Bushnell (UR)
Collaborators: UB, Roswell Park, Cornell
UR CTSI Center for Experimental Therapeutics
(NIH NCATS)
Karl Kieburtz, MD, MPH (UR)
Collaborators: UB, ACP
Acknowledgments: UNYTE recognizes the vision of Dr. Bruce A. Holm to establish strategic partnerships with the University of Rochester and UNYTE members to collaborate in building the capacity for translational research across upstate New York.
UR CTSA award # UL1 RR ; UB subaward 5UL1RR