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VACCINOLOGY (BIO-301) Credit Hrs 3(2-1) Dr. Aneela javed
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Objectives The aim of the course is to
Introduce students to the various disciplines associated with vaccinology including vaccine development The relevant basic sciences such as immunology, microbiology and molecular biology clinical trials vaccine safety, ethics vaccine-economics vaccination strategies and evaluation of vaccines.
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Course Contents An introduction to Vaccinology
Vaccine history and types Epidemiologic basis of Vaccinology Role of combination vs. single vaccines The immune responses to the pathogen & vaccine development Immunology of Vaccines Antigen and Vaccine Delivery Strategies Determinants of Vaccine Availability Vaccine development strategies: New approaches Live versus attenuated vaccines Role of multinational companies in vaccines production DNA as vaccine Peptide & Subunits vaccine Adjuvants in vaccines Population Genetic analysis: immunity to vaccine Recombinant vaccine Animal models of vaccine testing Vaccine Delivery Systems Practical issues in relation to trials Ethical issues related to clinical evaluation of vaccines Vaccine safety Review of vaccines in current use Vaccine-economics Future of Vaccines/Vaccination
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Course Contents PART 1 : INTRODUCTION Definition History Types
Combination vs single vaccine Part 2: Principles of Vaccine Design Immunologic Memory: T and B Cells memory Antigen Processing and Presentation by MHC Class I, II, and Nonclassical Molecules Understanding the Mucosal Immune System for Better Mucosal Vaccine Design Part 3: ANIMAL MODELS FOR VACCNE TESTING Utility of Mouse Models in Vaccine Design and Development, Utility of Nonhuman Primate Models for Vaccines,
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Part 4: Delivery Systems
Transcutaneous Immunization via Vaccine Patch Delivery System Needle-free Jet Injection for Vaccine Administration Oral Vaccines: An Old Need and Some New Possibilities Adjuvants: Part 5: Evaluating Vaccine Efficacy Trials in human and practical issues Part 6: Regulatory Considerations Regulatory Issues Role of international companies Vaccine economics PART 7: Population genetics and vaccines Ethical issues Vaccine safety
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Antigen Engineering Sequence-Based Computational Approaches to Vaccine Discovery and Design Antigen Discovery for Vaccines Using High-throughput Proteomic Screening Technologies, Phage Libraries Attenuated Bacterial Vaccines Virus-like Particles as Antigen Scaffolds Recombinant MVA vaccines: Optimization, Preclinical, and Product Development Recombinant Adenoviruses for Vaccination Recombinant Avipoxviruses, Intracellular Facultative Bacterial Vectors for Cancer Immunotherapy Nucleic Acid Vaccination, Artificial Antigen-presenting Cells: Large Multivalent Immunogens
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BOOKS Recommended Books:
The Vaccine Controversy: The History, Use, and Safety of Vaccinations by Kurt Link; Praeger. Novel Vaccination Strategies by Stefan H. E. Kaufmann. Vaccinia, Vaccination, Vaccinology - Jenner, Pasteur and Their Successors by Pasteur, B. Fantini, S.A. Plotkin Progress in Vaccinology by Richard Moxon. The Virus and the Vaccine: Contaminated Vaccine, Deadly Cancers, and Government Neglect by Debbie Bookchin and Jim Schumacher.
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Rules 2 OHTs….skip rule…. makeup 6 quiz/surprise test…no makeup
Class participation…. Assignments/Presentation /project Review of vaccines in current used in pakistan
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PRE- REQUISITE(s) Cell Biology, Microbiology and Virology, Basic Immunonology
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REVISION Cell Biology, Microbiology and Virology, Basic Immunonology
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HISTORY
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1796
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TYPES
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infectious bovine rhinotracheitis (IBR)
Bovine viral diarrhoea virus (BVDV)
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ANTIGENICITY TOXICITY
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FORMALIN
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ADVANTAGES
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