1. Glucocerebrosidase mRNA is Diminished in Brain of Lewy Body Diseases and Changes with Disease Progression in Blood
Perez-Roca Laia 1 ;Adame-Castillo Cristina 1 ;Campdelacreu Jaume 2 ;Ispierto Lourdes 3 ;Vilas Dolores 3 ;Rene Ramon 2 ;Alvarez Ramiro 3 ;Gascon-Bayarri Jordi 2 ;A. Serrano-Munoz Maria 1 ;Ariza Aurelio 1 ;Beyer Katrin 1 ;
1 Department of Pathology, Hospital Universitari and Health Sciences Research Institute Germans Trias i Pujol, Universitat Aut#cod#x000F2;noma de Barcelona, Spain ; 2 Department of Neurology, Hospital Universitari de Bellvitge, L#cod#x02019;Hospitalet de Llobregat, Spain ; 3 Department of Neurology, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain. ;
Figure 3. Expression profiles of GBA1 isoforms in three brain areas of LBD after adjustment with controls. The included areas were temporal cortex TC and caudate nucleus Ca from the groups of pure dementia with Lewy bodies pDLB, common dementia with Lewy bodies cDLB, Parkinson#cod#x000B4;s disease without dementia PDND and Parkinson#cod#x000B4;s disease with dementia PDD. The results are shown as relative expression changes obtained by the #cod#x00394;#cod#x00394;Ct method in comparison with normal controls and are represented in a logarithmic scale. Grey areas represent normal expression range. #cod#x0002A; Significant expression change below 0.5.
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