1. Canine Multi-focal Retinopathy
Andy Perrige
Eileen Harris

2. Classification
Homozygous Recessive
M= No CMR
m= CMR m mm

3. Background/History 1st found by Dr. Bruce Grahn in 1998.
1st breed Great Pyrenees.
Found in puppies before 4 months.

4. Cause of CMR Bestrophin Gene Mutations Not a sex chromosome
both parents must pass on the gene

5. Animals Affected
Dogs
Mastiff, Coton, and Pyrenees

6. What breeds does this occur in most?
To right: Coton de tulear
To the Left:
Great Pyrenees
Above: Mastiffs
(English,
Bull, French,
or Dogue de Bordeaux)

7. Signs/Symptoms Most Symptoms are minor Worst cause Detached retinas
Retinal folding
Fuzzy sight
Night vision
Worst cause
Detached retinas

8. Prevention/Treatment
Test cost $95
Potential for treatment
Best Muscular Dystrophy (BMD)

9. Questions?

10. What are the test to find it?
Genetic Testing
All ages
Results always same

11. What is the probability that dogs will obtain this disease?
Both parent must be a carrier, or afflicted m mm M m Mm mm
Both Afflicted
100%
Both Carriers
25% A. 75% C.

12. Work Cited http://www.optigen.com/opt9_test_cmr.html