1. National Cancer Institute
NCI Community Oncology Research Program (NCORP) & SWOG “Leading Cancer Research. Together”
National Cancer Institute
Heng Xie, M.D., M.P.H., Ph.D.
Community Oncology and Prevention Trials Research Group
Division of Cancer Prevention
SWOG NCORP Research Base Clinical Trials Workskhop September 14, 2016
U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health

2. Outline NCORP and SWOG at a Glance NCORP's Research Agenda
How Does SWOG Contribute to NCORP’s Goals?
SWOG’s Achievements

3. NCORP at Glance: FY 2015 Funding
7 Research Bases
Total FY 2015 awards - $41.8M
34 Community Sites
12 Minority/Underserved Community Sites
Total FY 2015 awards $9.4M

4. SWOG at a Glance
>12,466 cancer researchers at more than 1032 institutions
24 NCI-designated Cancer Centers
6 other countries
30 NCORP affiliates (677 embedded components and 4 NCORPs are NCI designated Cancer Centers)
>200,000 patients enrolled onto more than 1,000 trials since 1956
At least 12 major cancer drug approvals in cancer treatment
Establishment of the Veterans Administration Integration Support Program
National innovative precision medicine trials (Lung-MAP and Moonshot Program)

5. Cancer care deliver research Cancer disparities
NCORP's Research Areas
Clinical trials
Cancer care deliver research
Cancer disparities

6. NCORP's Overall Research Agenda
Reducing cancer risk and incidence
Improving cancer care outcomes
Expanding access to cancer care
Increasing quality and balancing cost
Reducing cancer disparities

7. SWOG’s Contributions to NCORP
Clinical Trials & Translational Research Advisory Committee (CTAC)
Michael LeBlanc
NCI Community Oncology Cardiotoxicity Task Force
Carol Fabian
Michael Fisch
Network Accrual Core Team (ACT)
Dana Sparks
Karen Anderson
Coverage Analysis Working Group
Casey Dawson
Tameka Lewis

8. SWOG’s Contributions to NCORP
NCI CIRB
Adult - Late Phase Emphasis
John Ellerton – Nevada
Joan Westendorp – West Michigan
Adult - Early Phase Emphasis
James Bearden – SCOR
Cancer Prevention and Control
James Wade – Heartland (Chair)
David Page - Pacific
Connie Szczepanek – West Michigan
Loren Tschetter - Sanford
Debra Wujcik – Baptist Health

9. SWOG NCORP Committees Prevention and Epidemiology Cancer Care Delivery
Survivorship
Symptom Control and Quality of Life

10. NCORP Study Concepts Submitted (Since NCORP’s Inception)
No. of concepts submitted
No. of approval
% of approved 6 4
66%
SWOG has the highest concept approval rate within NCORP

11. Accruing SWOG NCORP Studies
Prevention Committee
S0820 (PACES)
Cancer Care Delivery Committee
S1204 (Viral testing) – Legacy CCD study
S1417CD (Financial toxicity)
Survivorship Committee
S1316 (Prospective comparative effectiveness trial for malignant bowel obstruction)
Symptom Control and Quality of Life Committee
S1013 (Skin toxicity - treatment effects) – closing 10/1/16
S1200 (Acupuncture – AIs induced joint pain)
PRO Translational Medicine endpoints are being added to many therapeutic protocols

12. SWOG NCORP Studies in Follow-up
Prevention Committee
S0812 (Vitamin D for high breast cancer risk)
Cancer Care Delivery Committee
S1105 (Text messaging to help AI medication) – Legacy CCD study
Survivorship Committee
S1008 (Weight loss intervention by physical activity, diet, and counseling )
Symptom Control and Quality of Life Committee
S0702 (Osteonecrosis of the Jaw in Patients With Cancer Receiving Zoledronic Acid for Bone Metastases - registry)
We need your help to complete the data collection and follow-up for these important trials!

13. SWOG NCORP Studies Opening Soon
Cancer Care Delivery Committee
S1415CD-TRACER (Prophylactic G-CSF delivery)
Survivorship Committee
S1501 (Cardiotoxicity)

14. SWOG’s Top Leadership

15. SWOG NCORP Committee Leadership
Cancer Care Delivery -
Dawn Hershman, MD, MS and Scott Ramsey, MD, PhD
Cancer Survivorship
Carol Fabian, MD and Robert Krouse, MD, FACS
Prevention and Epidemiology
Marian Neuhouser, PhD, RD and Banu Arun, MD
Symptom Control and Quality of Life
Michael Fisch, MD, PhD and Lynn Henry, MD

16. SWOG’s UG1 Grant and Program Involvement

17. Happy Sixtieth Birthday!
SWOG
Happy Sixtieth Birthday!
Thank you!