1. From: Acetylation Preserves Retinal Ganglion Cell Structure and Function in a Chronic Model of Ocular Hypertension
Invest. Ophthalmol. Vis. Sci ;55(11): doi: /iovs
Figure Legend:
Effect of HDAC inhibition on functional neuroprotection using pattern electroretinography (pERG). Animals were treated with vehicle or valproic acid (VPA; 100 mg/kg; i.p.) twice daily on days 0 to 28, and resulting pERG amplitudes were recorded. (A) VPA administration showed significant preservation in raw pERG amplitudes compared to vehicle-treated counterparts at 2 weeks (8.9 ± 0.3 vs. 7.7 ± 0.5 μV) and 4 weeks (8.4 ± 1.0 vs. 6.1 ± 0.4 μV) post hypertension initiation. (B) Percentage reduction in pERG amplitudes of hypertensive eyes relative to normotensive contralateral control eyes (set at 0%). The decrease in pERG amplitudes of hypertensive eyes was calculated as a percentage of contralateral control eyes and adjusted by subtracting the absolute percentage change in amplitude of the contralateral control eyes from the respective baseline values. Vehicle-treated eyes demonstrated a 29.1 ± 1.9% and 39.4 ± 2.0% reduction at 2 weeks and 4 weeks, respectively. Eyes treated with VPA demonstrated significant preservation with 11.5 ± 1.7% and 12.4 ± 2.7% reduction at 2 weeks and 4 weeks, respectively (n = 10). (C) Representative pERG waveform from a control eye (blue) and ocular-hypertensive eye (black) at 4 weeks post injury initiation. Asterisk denotes significant difference between VPA-treated and vehicle-treated hypertensive groups. Data are expressed as mean ± SE. *P < 0.05; ψP < 0.01.
Date of download: 10/2/2017
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