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Pharmacology Tutoring for Hematopoietics
By Alaina Darby
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<1 month: liver and spleen 3-7 months: distal long bones
Which of the following is properly matched to the primary site of hematopoiesis? <1 month: liver and spleen 3-7 months: distal long bones 1-10 years: distal long bones >10 years: axial skeleton d
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Which of the following is not produced from a myeloid cell? NK cell
Eosinophil Mast cell Dendritic cell a
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Which of the following is not a symptom of anemia? Heavy menstruation
Swollen tongue GI dysfunction Dyspnea c
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Iron and folate deficiency Blood loss Infections and toxins
Which of the following is affiliated with erythrocyte survival disorders? Drugs and radiation Iron and folate deficiency Blood loss Infections and toxins c
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Which of the following describes normochromic normocytic anemia?
Decreased TIBC, decreased ferritin Decreased TIBC, increased ferritin Increased TIBC, increased ferritin Increased TIBC, decreased ferritin b
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Hypocellular bone marrow Pancytopenia Immature circulating cells
Which of the following is an indication of myelophthisic anemia, specifically? Hypocellular bone marrow Pancytopenia Immature circulating cells Normochromic RBCs c
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Which of the following is the most common cause of stem cell failure?
Whole body irradiation Viral infections Chemical agents and drugs Idiopathic d
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Activation of hypoxia-inducible factor Blood loss
Which of the following would not induce the kidney to secrete erythropoietin? Activation of hypoxia-inducible factor Blood loss Increased carbon dioxide Low oxygen c
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Myeloid growth factors Thrombopoetin Interleukin-11
Which of the following is not available for therapeutic use in a recombinant form? Erythropoietin Myeloid growth factors Thrombopoetin Interleukin-11 c
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Which of the following is the primary use of erythropoietin?
Chemotherapy AIDS Poor erythropoietin response Renal failure d
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Which of the following is a contraindication for erythropoietin?
Hyperthyroidism Ischemic heart disease Kidney failure Liver failure b
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Which of the following is not true of myeloid growth factors?
Produced by fibroblasts and T cells Enhances function of lymphocytes and granulocytes Active at low concentrations Stimulates proliferation of lymphocytes and monocytes b
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Which of the following is not true of sargramostim?
Useful during bone marrow transplant and intensive chemotherapy Administration may be followed by a drop in granulocytes May cause flu-like symptoms and bone pain at high doses Is used to stimulate myelopoiesis therapeutically b
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Which of the following is properly paired? Filgrastim: G-CSF
Sargramostim: G-CSF Pegfilgrastim: GM-CSF Filgrastim: GM-CSF a
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Which of the following does not produce thrombopoietin? T-cells Liver
Stromal cells Bone marrow a
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Which of the following is not a peptide and therefore can be given by mouth?
Filgrastim Oprelvekin Eltrombopag Romiplostim c
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Which of the following does not act through a megakaryocyte receptor to increase platelets?
Eltrombopag Oprelvekin Romiplostim Thrombopoietin b
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Which of the following is the most common nutritional deficiency? B12
Folate Iron Copper c
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Which of the following is not a characteristic of iron deficiency?
Decreased heat production Muscle fatigue Learning and behavioral problems Megaloblastic anemia d
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Which of the following is true of the majority of iron absorption?
Most through the duodenum in the heme-bound form Most through the duodenum in the free form Most through the ilium in the heme-bound form Most through the lilium in the free form a
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Which of the following is not exclusively used in the uptake of non-heme iron?
Mobilferrin Integrin Transferrin Mucin c
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Which of the following is true of iron transport and storage?
Ferritin is the transport protein Transferrin usually contains ug/dl Fe Transferrin is found in all tissues Normal transferrin is 1/3 filled with iron d
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Which of the following is not true of iron deficiency?
Decreased serum ferritin Decreased bone marrow iron Decreased transferrin Decreased serum iron c
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Which of the following is the primary cause of iron deficiency?
Increased demand (e.g. pregnancy) Dietary deficiency (e.g. vegetarian diet) External blood loss (e.g. menstrual loss) Intestinal malabsorption (e.g. PPI’s, antacids) c
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Which of the following is not a reason for prophylactic iron therapy?
Pregnanacy Heavy menstrual cycle Vegetarian diet Infant c
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Which of the following is the treatment of choice for iron therapy?
Ferrous gluconate Ferrous fumarate Polysaccharide iron complex Ferrous sulfate d
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Polysaccharide iron complex Ferrous sulfate
Which of the following is the treatment of choice for those who have difficulty tolerating iron therapy? Ferrous gluconate Ferrous fumarate Polysaccharide iron complex Ferrous sulfate a
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She should include vitamin C for better absorption
Amber is starting iron therapy due to heavy menstrual cycles. Which of the following should not be a counseling point? She should include vitamin C for better absorption She should take the enteric coated version if it upsets her stomach She may experience heartburn, nausea, constipation, and/or diarrhea She may take it orally b
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Which of the following is not true of iron poisoning?
It may include cardiovascular collapse Deferoxamine work by alkylating the blood Vomiting should be induced It most commonly occurs in children b
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Which of the following is not true of parenteral iron?
It is routine for parenteral nutrition Iron dextran has fewer side effects than dexferrum IM is preferred to IV Often given to patients with renal disease receiving erythropoietin c
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Which of the following is not true of copper deficiency?
Interferes with iron absorption Occurs in patients ingesting excessive zinc Treated with cupric sulfate Affects red blood cells but not leukocytes d
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Which of the following should be supplemented in sideroblastic anemia?
Copper B6 B12 Folate b
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Which of the following results from loss of intrinsic factor?
Sideroblastic anemia Pernicious anemia Myelophthisic anemia Aplastic anemia b
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Intrinsic factor aids in B12 absorption in the duodenum
Which of the following is not true of thymidylate synthetase activation? Intrinsic factor aids in B12 absorption in the duodenum Vitamin B12 demthylates tetrahydrofolate Tetrahydrofolate is the active form of folate Tetrahydrofolate is necessary for conversion of dUMP to dTMP a
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Circumvents dihydrofolate reductase inhibition
Which of the following is not true of treatment with the F-formyl derivative of tetrahydrofolate? Circumvents dihydrofolate reductase inhibition Potentiates fluoruracil treatment of colorectal cancer Can be given with methotrexate therapy Can be given with pyrimethamine d
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Which of the following would not be a precaution for folic acid therapy?
Use of antiepileptics Breastfeeding Malaria treatment Possible B12 deficiency B
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