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Antiemetics Tutoring By Alaina Darby
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Which of the following types of receptors is not present in the chemo-receptor trigger zone?
5-HT3 D2 M1 H1 D
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Which of the following has activity at only one type of receptor?
Scopolamine Ondansetron Droperidol Chlorpromazine B
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Which of the following does not have any activity at the serotonin receptor?
Scopolamine Ondansetron Droperidol Chlorpromazine A
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Which of the following is in the class that has been described as the most effective antiemetics to date? Scopolamine Ondansetron Droperidol Chlorpromazine B
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Concomitant administration with dexamethasone significantly increases potency of which of the following? Scopolamine Ondansetron Droperidol Chlorpromazine B
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Which of the following is true of serotonin antagonists?
Not effective when used alone since they only have effects at the serotonin receptor Antiemetic effects decline quickly after they are removed from circulation Block serotonin receptors in the stomach, small intestines, and CTZ Administered on an as needed basis C
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Which of the following has an extended half-life due to the production of an active metabolites?
Ondansetron Palonosetron Granisetron Dolasetron D
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Which of the following adverse effects is not commonly seen with serotonin antagonists?
Constipation GI discomfort Diarrhea Headache B
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Which of the following serotonin antagonists has the highest affinity for the serotonin receptor?
Ondansetron Palonosetron Granisetron Dolasetron B
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Which of the following serotonin antagonists has the longest half-life?
Ondansetron Palonosetron Granisetron Dolasetron B
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Which of the following serotonin antagonists has affinity for more than one type of serotonin receptor? Ondansetron Palonosetron Granisetron Dolasetron A
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Which of the following is used in combination with antiemetic agents to prevent peritumoral inflammation? Aprepitant Dexamethasone Ondansetron Chlorpromazine B
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Which of the following has central action and is used only as an adjunct therapy?
Aprepitant Dexamethasone Ondansetron Chlorpromazine A
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Serotonin antagonists Neurokinin 1 receptor antagonists Butyrophenones
Which of the following classes of antiemetics is most effective for chemotherapy- induced nausea? Serotonin antagonists Neurokinin 1 receptor antagonists Butyrophenones Phenothiazines A
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Serotonin antagonists Neurokinin 1 receptor antagonists Butyrophenones
Which of the following classes of antiemetics would be most valuable for motion sickness? Serotonin antagonists Neurokinin 1 receptor antagonists Butyrophenones Phenothiazines D
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Which of the following is given prophylactically prior to cancer chemotherapy and to prevent postoperative N/V? Chlorpromazine Droperidol Metoclopramide Dimenhydrinate C
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Which of the following does not describe the effects of meclizine?
Decreased stimulation of labyrinthine function Exerts anticholinergic effects to decrease vestibular secretions Works on vestibular afferents and within the brainstem Used to treat vertigo and Menier’s disease B
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Which of the following is not true of scopolamine?
May cause extrapyramidal effects Used to treat N/V from chemotherapy Works through an anticholinergic mechanism May cause sedation B
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Which of the following is used only when patients fail to respond to other antiemetics?
Metoclopramide Droperidol Dronabinol Lorazepam C
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Which of the following is given one day prior to chemotherapy?
Metoclopramide Droperidol Dronabinol Lorazepam D
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