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Necdin–E2F4 interaction provides insulin-sensitizing effect after weight loss induced by gastric bypass surgery  Zehra N. Pamuklar, M.D., Ph.D., Jiegen.

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Presentation on theme: "Necdin–E2F4 interaction provides insulin-sensitizing effect after weight loss induced by gastric bypass surgery  Zehra N. Pamuklar, M.D., Ph.D., Jiegen."— Presentation transcript:

1 Necdin–E2F4 interaction provides insulin-sensitizing effect after weight loss induced by gastric bypass surgery  Zehra N. Pamuklar, M.D., Ph.D., Jiegen Chen, Ph.D., Michael Muehlbauer, Ph.D., Anna Spagnoli, M.D., Alfonso Torquati, M.D., M.S.C.I.  Surgery for Obesity and Related Diseases  Volume 9, Issue 1, Pages (January 2013) DOI: /j.soard Copyright © 2013 American Society for Metabolic and Bariatric Surgery Terms and Conditions

2 Fig. 1 Free IGF-1 levels determined in plasma collected from obese patients (Obese), patients ≥12 months after RYGB, and nonobese controls (Lean). Data presented as mean ± SD. Surgery for Obesity and Related Diseases 2013 9, 94-99DOI: ( /j.soard ) Copyright © 2013 American Society for Metabolic and Bariatric Surgery Terms and Conditions

3 Fig. 2 Relative necdin and E2F4 RNA levels normalized to glyceraldehyde 3-phosphate dehydrogenase RNA levels in subcutaneous and omental adipose tissue collected from obese patients, patients ≥12 months after RYGB, and nonobese controls. Data presented as mean ± SEM. *P < .05 versus obese; **P < .01 versus obese. Surgery for Obesity and Related Diseases 2013 9, 94-99DOI: ( /j.soard ) Copyright © 2013 American Society for Metabolic and Bariatric Surgery Terms and Conditions

4 Fig. 3 Effect of des-IGF-1 on necdin and E2F4 gene expression in cultured adipocytes. Data presented as mean ± SEM. *P < .05 versus control; **P < .01 versus control. Surgery for Obesity and Related Diseases 2013 9, 94-99DOI: ( /j.soard ) Copyright © 2013 American Society for Metabolic and Bariatric Surgery Terms and Conditions


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