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Preface The aim of this atlas is to help the medical students in the reading of blood film for common hematological disorders; and to help them in the understanding of various tools used in the microbiological diagnosis. (cont.) 3
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Contents 4
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Blood film : Normal red cells
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Blood film : Normal platelets
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Blood film : Normal neutrophil
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Blood film : Normal lymphocyte
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Blood film : Reticulocyte
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Nucleated red cells {bone marrow irritation}
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Microcytes {IDA, Thalassemia, lead poisoning}
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Macrocytes {megaloblastic anemia, MDS}
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Macrocytes with hypersegmented neutrophil (more than 5 segments) {megaloblastic anemia}
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Anisocytosis (variable sizes) {non specific caused by many types of anemia}
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Poikilocytosis (variable shapes) {non specific caused by many types of anemia}
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Sickle cells {sickle cell anemia}
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Target cells {hemoglobinpathies, liver disease}
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Spherocytes {hereditary spherocytosis and AIHA}
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Elliptocytes (oval shape RBC) {hereditary elliptocytosis}
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Stomatocytes {hereditary stomatocytosis, alcoholism}
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Echinocytes (burr cells) {CRF, in vitro artifact}
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Acanthocytes (spur cells) {liver disease, a B- lipoproteinemia}
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Schistocytes (Fragmented cells) {traumatic hemolytic anemia: DIC, TTP, prosthetic valve}
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Bite cells (blister cells) {G6PD deficiency anemia}
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Teardrop cells {myelofibrosis}
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Agglutinated red cells {cold agglutinin hemolytic anemia}
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Rouleaux formation {multiple myeloma, macroglobulinemia}
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Basophilic stippling {hemolysis, lead poisoning}
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Heinz bodies (Hb polymers) {hemoglobinpathies, G6PD deficiency}
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Howell Jolly bodies (nuclear remnants) {post- splenoectomy}
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Lymphoblasts {ALL} 31
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Myeloblasts {AML} 32
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Auer rod {AML} 33
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Leukocytosis with relative lymphocytosis {CLL}
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Leukocytosis ranging from myeloblasts to mature neutrophils {CML}
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Abnormal lymphocyte {hairy cell leukemia}
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Atypical lymphocyte {viral infections, toxoplasmosis, lymphoma}
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Increase platelets count {Essential thrombocythemia}
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Bone marrow: Ring sideroblast {MDS: refractory anemia with ring sideroblast}
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Bone marrow: Predominance of plasma cells {multiple myeloma}
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Lymph node biopsy: Reed Sternberg cells {Hodgkin's lymphoma}
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