1. Warm-Up (1/27)
Answer the following questions, and explain in a complete sentence why each answer is correct.
Name
Date
Period
If a paramecium (a one-celled eukaryotic organism) is placed in a hypertonic environment, which of the following will occur?
Water will diffuse into the paramecium.
Water will diffuse out of the paramecium.
Salt will be pumped out of the paramecium by the vacuole.
Salt will be pumped into the paramecium by the vacuole.
Draw a Punnett square showing a cross between a heterozygous person and a homozygous person for the A gene (“A” is the dominant allele; “a” is the recessive allele). What fraction of the offspring will show the dominant phenotype?

2. Mutations A DNA sequence: nucleus TAC CAC GTG GAC TGA GGA CTC CTC TTC
Transcribe the mRNA sequence:
TAC CAC GTG GAC TGA GGA CTC CTC TTC
AUG GUG CAC CUG ACU CCU GAG GAG AAG

3. Mutations nucleus TAC CAC GTG GAC TGA GGA CTC CTC TTC
AUG GUG CAC CUG ACU CCU GAG GAG AAG
Translate the mRNA sequence into an protein:
AUG GUG CAC CUG ACU CCU GAG GAG AAG
Met Val His Leu Thr Pro Glu Glu Lys

4. Mutations A mutation is a change in DNA.
TAC CAC GTG GAC TGA GGA CAC CTC TTC
Transcribe the new mRNA.
AUG GUG CAC CUG ACU CCU GUG GAG AAG
Translate the new protein.
Met Val His Leu Thr Pro Val Glu Lys

5. Mutations A mutation is a change in DNA.
This changes the mRNA, which changes the protein.
Normal Hemoglobin Protein
Mutated Hemoglobin Protein
Hemoglobin Video 1st 2 minutes

6. What do you see?

10. *you don’t have to write this down!
Diseases that can occur with by a substitution or point mutation.
Color blindness
Cystic Fibrosis
Cancer
Tay-Sachs disease
Sickle-cell anemia
*you don’t have to write this down!

11. Mutations A mutation is a change in DNA.
This changes the mRNA, which changes the protein.
Substitution – replacing one nucleotide for another.
Insertion – adding a nucleotide.
Deletion – removing a nucleotide.
old: ATG GAG GGA
new: ATC GAG GGA
old: ATG GAG GGA
new: ATG CGA GGG A
old: ATG GAG GGA
new: ATG AGG GA

12. Carousel Activity
6 for a 70%
12 for a 100%

13. Closure
Answer the following question in a complete sentence:
Name
Date
Period
If a DNA sequence is changed from TAC to TGC, how will the resulting amino acid change?
Scale from 1-10