1. Wolfgang E. Kaminski 1 ;Alexander W. Beham 2 ;Kerstin Puellmann 3 ;
Extralymphocytic Flexible Immune Recognition: a New Angle on Inflammation and Aging
Wolfgang E. Kaminski 1 ;Alexander W. Beham 2 ;Kerstin Puellmann 3 ;
1 Institute for Clinical Chemistry, University of Heidelberg Medical Faculty Mannheim, Mannheim, Germany ; 2 Department of Surgery, University of Göttingen, Göttingen, Germany ; 3 Institute for Clinical Chemistry, Hannover Medical School, Hannover, Germany ;
Figure Conccurrent decline of the capacities for phagocytosis and flexible immune recognition in myeloid phagocytes during aging. The myeloid machinery for flexible immune recognition is based on the recently identified recombinatorial TCRL. This process is paralleled by the decline of the T cell receptor TCR in the lymphoid lineage.
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