1. National Nutrition Phenotype Database
Apologies, welcome, introductions
Minutes of the last meeting
Matters arising
Consortium Agreement
Accessibility to the data
Website and communications
Report from the three clusters
Metabolically challenged cohort
Elderly cohort
National representative sample
Agree points of action
Date and place of next meeting
Any other business

2. National Nutrition Phenotype Database
Apologies, welcome, introductions
Minutes of the last meeting
Matters arising
Consortium Agreement
Accessibility to the data
Website and communications
Report from the three clusters
Metabolically challenged cohort
Elderly cohort
National representative sample
Agree points of action
Date and place of next meeting
Any other business

3. National Nutrition Phenotype Database
Apologies, welcome, introductions
Minutes of the last meeting
Matters arising
Consortium Agreement
Accessibility to the data
Website and communications
Report from the three clusters
Metabolically challenged cohort
Elderly cohort
National representative sample
Agree points of action
Date and place of next meeting
Any other business

4. Standard FP7 Consortium Agreement

5. National Nutrition Phenotype Database
Apologies, welcome, introductions
Minutes of the last meeting
Matters arising
Consortium Agreement
Accessibility to the data
Website and communications
Report from the three clusters
Metabolically challenged cohort
Elderly cohort
National representative sample
Agree points of action
Date and place of next meeting
Any other business

6. Data access
Limited
Open access

7. National Nutrition Phenotype Database
Apologies, welcome, introductions
Minutes of the last meeting
Matters arising
Consortium Agreement
Accessibility to the data
Website and communications
Report from the three clusters
Metabolically challenged cohort
Elderly cohort
National representative sample
Agree points of action
Date and place of next meeting
Any other business

10. Marine
Functional food
Dairy
Functional food
National
Diet survey
National Nutrition
Phenotype Database

11. About nutritional phenotypes The partners Contact us
National Nutrition
Phenotype Database
About nutritional
phenotypes
The partners
Contact us

13. National Nutrition Phenotype Database
Apologies, welcome, introductions
Minutes of the last meeting
Matters arising
Consortium Agreement
Accessibility to the data
Website and communications
Report from the three clusters
Elderly cohort
Metabolically challenged cohort
National representative sample
Agree points of action
Date and place of next meeting
Any other business

14. NNPD Metabolically-Challenged Cohort Study
Ethics proposal submission: 19th May 2008
Estimated start date: September 2008
Estimated duration of study: 36 months

15. Study Objective
To create a component of the national nutritional phenotype database that represents the metabolic stress from varying body-weight overlaid by the additional metabolic stress of a test meal

16. Glucose
Fat Δ 1 4

20. Develop central hypotheses (examples)
- Effects of a metabolic challenge on the metabolomic profile.
- How do metabolomics profiles change with time in the post-prandial state?
- Is clustering of baseline metabolomic data still evident in the post- prandial data?
- Can we identify a metabolic phenotype with respect to post-prandial response using baseline metabolomics?

21. #1. Options for Study Design 600 x 1 as in the grant or 200 X x 1 or 100 x x x1

22. #1. Options for Study Design
200 subjects visited once +
200 subjects visited twice
= 600 EVENTS
RECRUITMENT CONTROL DIET CLINICAL INVESTIGATION MORNING (CIM)
200 Norm (Measurements + Test Drink)
200 Overweight
200 Obese
Phase Phase 2
RECRUITMENT CONTROL DIET CIM CONTROL DIET CIM
100 Norm
100 Overweight
100 Obese

23. #2. Inclusion & exclusion
Wide inclusion, narrow exclusion preferred

24. #3 ~ Recruitment Wide: Email/ Companies/ Hospital/ GP practices…
- Males/females yrs (focus: 25-45yr)
- Wide BMI range 18.5 – 45kg.m2
200 Norm
200 Overweight
200 Obese
- “Healthy” (NO medication, except for contraceptive pill) …

25. #4 ~ Test meal Test meal Test Meal 1 only or two Liquid (preferred)
Solid
Mixed

26. #5 ~ Measurements: Clinical Investigation Morning
Transport
Volume
Analytes
Frequency
Storage
Collection
Processing

27. #6 Control Diet Objective:
To minimise variability between subjects prior to starting. Weight should remain stable during this period
Options:
Total 4 week run in control
Provision of a list of “authorised”/ “non-authorised” Foods and Drinks (Preferred)
No control