1. International Medical Cluster
Project information for potential participants

2. Summary
The International Medical Cluster (IMC) provides unique business development opportunities in the medical sector:
The Cluster is established with the purpose of supporting the advancement of medical services, improving their quality, assisting the development of new drugs, medical technologies and products, enabling education and research efforts in the field of healthcare based on the best existing international practices
The IMC operations are regulated by Federal Law No.160-FZ "On the International Medical Cluster" that specifies the conditions for building and developing an International Medical Cluster within the legislation context of the Russian Federation
In accordance with the current regulations, the participants of the project are entitled to a number of exceptions in terms of applying OECD standards and recruiting foreign specialists. The IMC participants are also entitled to special support from the IMC Fund under the PPP framework
In terms of cluster development, the IMC is now interested in finding investors and operators across a wide range of medical services, education, and R&D1 models
In the near future the International Medical Cluster (IMC) will be located at the Skolkovo Innovation Center, occupying a dedicated territory of 57.6 hectares. The total area of the facilities will be up to 450,000 m2
1. Research & Development

3. Agenda General overview Opportunities for potential participants
Appendix

4. In line with IMC vision and objectives, investors and operators are given a whole range of participation options
Vision
The International Medical Cluster (IMC) is intended to assist the development of Moscow healthcare sector in line with the best state-of-the-art international practices as well as key Russian sector development trends
Objectives
Enhancing medical care by providing medical assistance and improving its quality using best international practice and treatment methodologies
Assisting the development and commercialization of drugs, medical technologies and
products in Russia and abroad
Developing education and research activities in healthcare with the involvement of international experts in medical education
Promoting international cooperation in healthcare sector

5. In accordance with 160-FZ, IMC provides unique business development conditions in the medical sector
Opportunity to participate in innovative development
of healthcare system
Special benefits for project participants
Support from the Moscow City Government
International Medical Cluster (IMC) is established in accordance with 160-FZ. This law provides a special area for business development within the IMC and a number of preferences to project participants
Within the IMC, the permits issued by foreign OECD member countries are equally valid as the permits issued in the Russian Federation
Project participants are not required to obtain special permits to recruit and use the services of expat specialists in the field of medicine, education, or scientific research
Invitations and job permits are issued to foreign specialists, regardless of the existing quotas
Education certificates and (or) qualification papers of expat specialists from OECD member countries are recognized by the IMC
According to its Mission, the IMC Fund shall provide all necessary support to the participants of the project
Supporting project participants by providing the necessary services
Coordinating project participants and supporting the interfaces between them
Setting up training and internship projects for the necessary talent pool
Assisting the promotion of products and services, and developing the R&D cooperation of project participants
Government relations
Copyright and Branding
The IMC Fund is prepared to address and set up various forms and types of support, including those under the PPP framework
The International Medical Cluster (IMC) is intended to assist the development of Moscow healthcare sector in line with the best state-of-the-art international practices as well as key Russian sector development trends
Developing medical activities and medical care, improving its quality
Developing new drugs, medical technologies, and products
Supporting education and research activities in the field of healthcare
Promoting international cooperation in medical services and innovations

6. General cluster vision: medical services, education and R&D are the key components
Funding and commercialization II
Education
Governing body
III
Research and Development IV
Production
Target development degree:
Target development sequence
High
Medium
Low
1st priority
2nd priority
3rd priority
Key components

7. Three development horizons are considered for the Cluster
Illustrative
Pilot objects
First cluster facilities to be commissioned in
Facilities located on Skolkovo territory
Construction already in progress
Skolkovo
Cluster in Skolkovo
A dedicated territory of 57.6 hectares is assigned for construction of IMC facilities
Assumed total development area – up to 450,000 m2
Moscow
Cluster in Moscow
Further cluster development is not limited to Skolkovo territory
Development in other Moscow areas could be carried out in parallel with construction of pilot and other facilities on Skolkovo territory

8. Territory of 57.6 hectares is assigned for IMC in Skolkovo IC
IMC deployment at the Skolkovo Innovation Center
D1 and D4 area plots D1 D4
Area of IMC facilities in the Skolkovo Innovation Center
57.6 hectares
Planned development area
450,000 m2
D1 area plots
D4 Area
D4 area plots
D1 Area
IMC site

9. IMC will be located side by side with wide infrastructure of Skolkovo Innovation Center
Readiness in 2015
Readiness in 2016
Readiness in 2017
Readiness by end of 2020
International Medical Cluster, development in
Projects undergoing development phase
75%
Total construction area
2.6
M m2
NTC TMC
Skoltech - MIT University
HyperCube (completed)
D2 apartment
Family campus
Technopark
Renova Lab
Boeing
Technopark (completed)
Sberbank DPC
BCG Gallereya IT-cluster
MFC «Kvadrat»
Transport
Hub
Sberbank Technopark
Facility
Contractor readiness
Total area, m2
Fund resources
Investment
Total
SkolTech
214,704
by end 2015 -
2016
139,554
2017
75,150
Technopark
160,081
95,246
64,835
R&D offices and centers
724,420
Key partners
360,824
5,050
173,505
91,750
90,519
Other R&D offices and centers
363,596
5,856
73,271
79,127
78,300
206,169
Apartments, row houses, villas
690,730
8,642
41,953
81,928
558,207
Transport and engineering infrastructure
309,828
26,679
14,357
41,036
45,000
43,440
180,352
Social infrastructure
523,088
1,836
32,779
20,077
468,396
Total before 2018 
979,223
Second construction phase ( )
1,643,628
Total in Skolkovo IC (rounded)
2,623,000
IMC (approximately)
400,000
3,023,000
* Facilities area and functional purpose to be clarified at project concept approval phase

10. Wide transport infrastructure is planned to be developed within the framework of Skolkovo Innovation Center
Planned development of external and internal Skolkovo IC transport infrastructure until 2020 allows
Managing daily inbound and outbound transport flows
Ensuring comfortable movement within the city for citizens and visitors
The ride to Moscow center will take minutes after completion of North-Western chord
Bicycle routes

11. IMC is actively developing; all necessary conditions are set-up for participants to join the cluster
Current results
IMC concept developed
The Concept defines key development directions as well as requirements to cluster participants
Medical technical assignment is prepared for the construction of Phase I and II facilities
Phase I construction is already started
Potential operator for Phase I and II facilities is identified
Hadassah Medical center (Israel)
Cluster territory already has all required engineering and transport infrastructure

12. Potential cluster composition has been visualized
Illustration of possible cluster composition
Pilot objects
D1 area 1
Diagnostic building
Construction
in progress 2
Medical center (oncology) 3
Interdisciplinary medical complex with a clinical unit 1 4
Orthopaedics and traumatology 2 5
Multi-purpose rehabilitation center 3 6
Hotel facilities & Retail 7
Children clinic 8
ENT 4 9
Ophthalmology 18 10
Apartments 17 5 16 11
Offices & Retail 13 6 12
Endocrinology 15 14 13
Gastroenterology 12 10 11 14
Gynecology 15
Urology 16
Educational center 8 7 19 17
Neurology 9 18
Cardiology 20 19
Underground parking
IMC plot borders 20
Above-ground parking

13. IMC facilities position on Skolkovo Innovation Center territory
D1 Area
IMC facilities
D4 Area

14. Agenda General overview Opportunities for potential participants
Appendix

15. The IMC is now looking for participants in the areas of medical services, education, and R&D
Potential model examples — non-exhaustive
Potential partners and operators
Scope
Potential development models
Medical services
Entire range from a multidisciplinary clinic to individual elements, e.g.
Orthopedics and trauma center
Specialized cardiovascular clinic
Rehabilitation center
International partner clinic
Education
Educational programs both within the framework of the clinic, as well as standalone education projects. E.g.
Simulation center
Continuous education and refresher programs for doctors and paramedical staff
International medical schools
MedTech producers
Research and Development
Focused research programs with the possibility of employing IMC clinics' resources. E.g.
Development of standards
Setting up clinical research
Application of new treatment methods in cooperation with IMC clinics
Pharmaceutical companies
MedTech producers
Attraction of international expertise and creation of international partnerships are an important requirement

16. Potential attractive models defined for medical providers – specific models to be discussed with IMC participants
Medical services
Indicative. Particular models and timing to be discussed with the participant ~ 6
facilities
6 + 8
facilities
Medical
facilities 1
Diagnostic building 1
Diagnostic building
Participants
already defined 2
Medical centre 2
Medical centre 3
Interdisciplinary building1 3
Interdisciplinary building1 4
Cardiology 4
Cardiology 5
Orthopaedics and traumatology 5
Orthopaedics and traumatology 6
Multi-purpose rehabilitation centre 6
Multi-purpose rehabilitation centre 7
Urology 8
Gynecology
Potential models
for future IMC
participants 9
ophthalmology 10
Children clinic 11
Endocrinology 12
Otolaryngology 13
Gastroenterology 14
Neurology
1. With a clinical unit, functionality to be defined

17. 9 priority programs in education defined for IMC
Operating models
Requirements to medical provider (IMC participant)
Standalone education operator (IMC participant)
Target audience
Program description
Medical
education
Full-cycle programs
Full-cycle education programs for doctors and nurses
Standalone educational operator can deliver any of the proposed models
Residency
Residency/practical training program for doctors in line with international standards of partner’s clinic
International exchange
Long-term internship in international partner clinic
Continuous education
Professional development program in chosen TA for doctors and nurses
Simulation center
Practical education program to train medical equipment operating skills
Advanced training courses
Short-term professional development courses in particular areas of medical services
Retraining of nurses
Practical training program for nurses in line with international standards of partner’s clinic
Business education
MBA
Business education and training program for executive management in medical sector
Business trainings
Short-term professional development courses on business topics for medical staff/management
Doctors
Nurses
Managers

18. 9 strategic target research areas were defined for R&D
Overall principle of R&D development at IMC
Priority – patients' needs and improvement of
treatment results (patient-centric approach) 9
Strategic areas
of R&D development at IMC
Predictive Medicine 1
Cross-disciplinary patient care based on new technologies 2
Behavioral patient care 3
Personalized medicine 4
Minimally invasive surgery 5
Care closest to patient 6 7
Survivorship, surveillance and assistance guidance 8
Data-driven healthcare 9
Translational research
Potential development topics also defined for key therapeutic areas (for more details – see Appendix)
...
...

19. Minimum operator participation Preferred operator participation
A number of operator requirements will help ensure the high quality of services provided in the cluster
Joint/ full investments
Sharing financial risks and profits
Defining strategy and controlling operations
Leveraging internal best practices, own staff and management
Brand
Providing international/local participant brand for an annual fee
Operations control
Expertise
Consulting services, access to in-house topic experts and best practices
Access to operational practices
Core medical staff
Providing a team of core medical staff
Staff training
Training of medical and management staff at HQ/cross-trainings
Management team
Providing a management team
Minimum operator participation
Preferred operator participation
Additionally, a medical facility operator may be required to participate in research and educational programs

20. Agenda General overview Opportunities for potential participants
Appendix

21. Construction is already in progress
As of today, the concept of the first pilot facilities is already in place
Construction is already in progress
First phase facilities
PHASE
III I
LEGEND:
1(а). Diagnostic Center (total area: 12,888 m2)
1(b) Medical Center (total area: 19,062 m2)
2. Phase III facilities (total area: circa 28,000m2)
3. O2 and Gasification Station
4. Planned P3 parking lot
Diagnostic Center - about 13,000 m2 comprising of:
Check Up Center – about 3,000 m2
Simulation center and conference hall – about 1,600 m2
Facilities for other residents of the cluster and support infrastructure – about 8,400 m2
Second phase facilities II
PHASE
Medical Center – about 19,000 m2
Phase 3 facilities
Functions being finalized. Total area of the facilities is about 28,000 m2

22. Visualization of Pilot Facilities
Phase III
Functions being finalized
~ 28,000 m2
Phase I
Diagnostic Center
~ 13,000 m2
Phase II
Medical Center
~ 19,000 m2

23. Possible R&D topics (1/3)
Examples of therapeutic areas
Examples of R&D topics (innovative
approaches) related to patient care
Oncology
Cardiology1
Orthopaedics
and traumatology 1
Vaccination against oncoviruses (e.g., HPV, hepatitis B)
Minimally invasive diagnostic methods
(for instance, "liquid biopsy" in oncology) 2 3
Immunotherapy
(including cell-programming technologies) 4
Molecularly targeted therapy
Oncolytic virotherapy 5 6
Gene transfer therapy
Cancer stem
cells therapy 7 8
Onco-psychology 9
Nano-drugs care
1. Including prevention and treatment of cardiometabolic syndrome Source: BCG analysis; interviews with external experts and BCG experts
This topic is innovative (an R&D topic) and is relevant to this therapeutic area
This topic is not innovative/is less relevant to this therapeutic area

24. Possible R&D topics (2/3)
Examples of therapeutic areas
Examples of R&D topics (innovative
approaches) related to patient care
Oncology
Cardiology1
Orthopaedics
and traumatology 10
Vaccination against atherosclerosis
Atheroma state estimation-based therapy 11 12
Angiogenesis-based therapy 13
Tissue engineering therapy 14
Stem-cell therapy
Polymedicine 15
Smart devices for blood circulation and arhythmia therapy support1 16 17
Modernized stents 18
Devices allowing to minimize repeated operations3
2. E.g. ICD – implantable cardioverter-defibrillator, including with an option of cardiac rhythm recording 3. E.g. self-powered cardiac pacemaker/valve fed by heart movements – excludes the need for surgical interference for battery changing Source: BCG analysis; interviews with external experts and BCG experts
This topic is not innovative/is less relevant to this therapeutic area
This topic is innovative (an R&D topic) and is relevant to this therapeutic area

25. Possible R&D topics (3/3)
Examples of therapeutic areas
Examples of R&D topics (innovative
approaches) related to patient care
Oncology
Cardiology1
Orthopaedics
and traumatology
Osteoporosis prevention 19 20
Prevention and treatment using
stem cells 21
Robot-assisted surgery
Meniscus implant 22
Bone morphogenetic protein (BMP)
application 23
Adaptive implant implementation 24 25
Bone implants 3D printing
Treatment and rehab
using exoskeletons 26
Development of biocompatible prostheses 27
Source: BCG analysis; interviews with external experts and BCG experts
This topic is innovative (an R&D topic) and is relevant to this therapeutic area
This topic is not innovative/is less relevant to this therapeutic area