1. The adrenal cortex consists of three histologically distinct zones: the outer zona glomerulosa, the middle zona fasciculata, and an innermost layer called the zona reticularis. Each zone is responsible for production of different hormones. The zona glomerulosa is responsible for the production of mineralocorticoids such as aldosterone. The zona fasciculata produces cortisol and the zona reticularis produces androgens. (ADX, adrenodoxin; CYP11A1, side chain cleavage enzyme; CYP11B1, 11-beta-hydroxylase; CYP11B2, aldosterone synthase; CYP17A1, 17-alpha-hydroxylase/17,20 lyase; CYP21A2, 21-alpha-hydroxylase; DHEA, dehydroepiandrosterone; DHEAS, dehydroepiandrosterone sulfate; H6PDH, hexose-6-phosphate dehydrogenase; HSD3B2, 3-beta-hydroxysteroid dehydrogenase type 2; HSD11B1, 11-beta-hydroxysteroid dehydrogenase type 1; HSD11B2, 11-beta-hydroxysteroid dehydrogenase type 2; HSD17B, 17-beta-hydroxysteroid dehydrogenase; PAPSS2, PAPS synthase type 2; POR, P450 oxidoreductase; SRD5A, 5-alpha-reductase; SULT2A1, DHEA sulfotransferase.) (Adapted, with permission, from Arlt W. Disorders of the adrenal cortex. In: Longo DL, Fauci AS, Kasper DL, et al., eds. Harrison's Principles of Internal Medicine. New York: McGraw-Hill; 2012.)
Source: Endocrinologic Disorders, Pharmacotherapy Principles & Practice, 3e
Citation: Chisholm-Burns MA, Wells BG, Schwinghammer TL, Malone PM, Kolesar JM, DiPiro JT. Pharmacotherapy Principles & Practice, 3e; 2013 Available at: Accessed: October 04, 2017
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