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DCE SMART Team 2011-2012: The Bubonic Plague
By Zach Peterson and Matt Gargulak Mentor: MSOE CBM Dr. Colton
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What is SMART? - Students Modeling A Research Topic - Organize groups
- Research the topic - Write an abstract - Use Jmol to recreate biomolecular structure
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History of the Bubonic Plague
- Plague of Justinian (500s) - First recorded epidemic - Black Death (1347) - Major outbreak in Europe - Treatment - Eat well, rest, and leave infected areas - Biological Warfare - 14th century armies used bubonic plague to their advantage
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http://upload. wikimedia
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Importance of the Bubonic Plague
- Common in rats - Transmitted through fleas to humans - Extremely contagious - Fast-acting - Had no cure /wikipedia/commons/d/d0/Y ersinia_pestis.jpghttp://uplo ad.wikimedia.org/wikipedia/ commons/d/d0/Yersinia_pest is.jpg /wikipedia/commons/c/c1/F lea_infected_with_yersinia_p estis.jpg
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Surface Protein - Pla - Gram-negative bacteria
- Attaches to cell walls in the lymph nodes - Attracts Plasminogen activator inhibitors (PAI) into negative pocket - Breaks peptide bonds
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Yersinia Pestis (Scientific Name)
- Most commonly caused by the bite of an infected rodent or parasite - Rarely transmitted by human contact - Common in unsanitary rural areas - Oftentimes fatal
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Yersinia Pestis (Scientific Name)
- Comes in three forms - Bubonic (Lymphatic) - Pneumonic (Respiratory) - Septicemic (Circulatory)
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Symptoms (Bubonic Plague)
- Gangrene - Chills - High fever - Muscle cramps - Seizures - Swollen lymph glands - Skin discoloration - Bleeding of the ears
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Why is it less common today?
- Increase in overall hygiene - Decrease in infected organisms - Change in climate - (1:56-2:58) g
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