1. Creating RDF Representations of Patient Data

2. Diabetes Patient Data
54-year-old man with diabetes was referred to the Hypertension Clinic in Jichi Medical School Hospital with symptoms of dizziness and orthostatic intolerance. In 2002, he started insulin therapy (Hemoglobin A1c 9 %), and in 2004, he was started on a once daily dose of valsartan 80 mg for hypertension. He sometimes complained of dizziness and fainting while standing. On 13 February 2005, he fell down while riding a bicycle. As the clinic BP was 84/60 mm Hg on 14 March, and the valsartan was stopped. He was referred to otolaryngology and neurology, but no significant abnormalities were detected.

3. URI
subject? or has_symptom?
age?
“54 years”
“Collection of Symptoms” _1 _2
“Dizziness”
“Orthostatic Intolerance”
maps_to
maps_to
Snomed URI2
Snomed URI1

4. Design Choices What are the nodes of this graph?
What are the types of the nodes of this graphs (RDF(S)/OWL Classes)?
What are the labels of the edges of this graph?
How do we decide the classes and instances?
How do we deal with Industry Standards such as RIM/CDA/SDTM/DCM + Snomed/NCI Thesaurus etc.?
Can node types and edge labels be derived from these standards?
Can we have specialized edge (“maps_to”) to link nodes in this graph with Snomed/NCI Thesaurus concepts?
How do we choose these to ensure interoperability across multiple standards?
How do we represent temporal data and information?
How do we capture abstractions such as a clinical event, a patient encounter?

5. Name Space Issues
Proposal: Create Namespaces for each of the standards
hl7rim: HL7/RIM
dcm: Detailed Clinical Models
cda: Clinical Documentation Architecture
sdtm: Study Data Tabulation Model
snomed: Snomed
ncit: NCI Thesaurus

6. How do we scope this effort?
Systolic Blood Pressure
Known head injury
Suspected head injury
Pregnancy
Type 2 diabetes
FPG
HbA1c
Women of childbearing potential
Type 1 diabetes
Ketacidosis
History of <Condition/Diagnosis>
Severe Diabetic Neuropathy
Autonomic Neuropathy
Gastroporesis
Lower Limb Ulceration
Lower Limb Amputation
Intentional Weight Loss
Period of time for Weight Loss
Serum creatinine
eGFR
Chronic Kidney Disease Stage 3

7. Proposed Tasks/Groups
HL7/RIM: Helen, Vipul, Dan
DCM: Tom Oniki, Stan Huff
Realist Approach: Kerstin, Bo, Alan
SDTM: Rachel, Jennifer
POMR: Vipul

8. Examples of
Eligibility Criteria
Example
Patient Data
Various Standards
HL7, CDISC, etc.
RDF/OWL Graphs