1. Mega 10TM

2. OmegaGenics Mega 10

3. OmegaGenics Mega 10 - Supplement Facts

4. The OmegaGenics Difference1
OmegaGenics offers a line of products that allow physicians to personalize patient care when recommending Omega 3 Fatty Acids 2
OmegaGenics satisfies a broad range of clinical applications and patient preferences 3
Formulas are tailored with specific omega ratios and dosages for targeted protocols. Available in liquids, softgels, chewables, enteric options, and triglyceride and ethyl ester oils
We bring more science
More dosing options
More delivery forms
More safety

5. Need for solutions targeting cardiovascular health
Cardiovascular disease affects 1.3M Canadians (4.8%)
Map from
Heart and Stroke Foundation: Accessed 7/15/2015

6. Need for solutions targeting cardiovascular health
Images at Available at: Accessed
Available at: Accessed

7. OmegaGenics Mega 10 Targeted Enhanced Support
OmegaGenics Mega 10 delivers a powerful combination of purified omega-7 and omega-3 fatty acids to provide targeted support for cardiovascular health
Omega-7 palmitoleic acid helps reduce blood levels of C-reactive protein, an inflammatory marker protein
Omega-3 EPA (eicosapentaenoic acid) and Omega-3 DHA (docosahexaenoic acid) help reduce serum triglycerides

8. 3) Omega-7 fatty acids and palmitoleic acid

9. Palmitoleic acid is a monounsaturated omega-7 fatty acid in Mega10H O OH
Monounsaturated
fatty acid
C16:1 ω -7
omega carbon
Palmitic Acid
There are three fatty acids which are particularly important in the formula for Mega10. The first of these is palmitoleic acid. Palmitoleic acid is a monounsaturated fatty acid, meaning it has one double bond. It is also an omega-7 fatty acid, meaning that the first double bond occurs on the 7th carbon counting from the omega carbon.
Palmitoleic acid is different from palmitic acid, which has the same number of carbons in its hydrocarbon chain (16 in total) but has no double bond, making it a saturated fat. The double bond in palmitoleic acid makes all the difference, and leads to these two fatty acids having different functions in the body. C H O OH
Saturated
fatty acid
C16:0

10. Why the need to supplement with palmitoleic acid?
Few foods contain omega-7 fatty acids and these are not consumed in large quantities in typical diets
Palmitoleic acid containing foods may also contain other fatty acids such as palmitic acid, a saturated fatty acid
So why should we supplement with palmitoleic acid?
Firstly, few foods contain meaningful amounts of palmitoleic acid
Secondly, many foods that do contain palmitoleic acid also contain the saturated fat palmitic acid
Thirdly, in clinical trials, direct supplementation with palmitoleic acid has been shown to improve cardiovascular risk markers
Supplementing directly with palmitoleic acid can reduce cardiovascular risk factors

11. What is palmitoleic acid?
Palmitoleic acid is an omega-7 mono unsaturated fatty acid. Very few foods naturally provide significant amounts of palmitoleic acid. Primary sources include plant oils and fish oils.1 In fact, it was first identified after isolation from herring and cod liver oils in
Table 1. Common Food Sources of Palmitoleic Acid1
Dietary Source
Palmitoleic Acid (g/100 g of Fatty Acids)
Macadamia nut oil
17.3%
Cod liver oil
7.1%
Salmon
6.0%
Olive oil
1.4%
Eggs
0.3%
Soybean oil
0.08%
Link image of report to: Clinical Application of Omega-7 & Omega-3 Fatty Acids in Cardiovascular Health (make sure most recent version)
Link reference 1 to:
Link reference 2 to:
Mega 10 omega-7 palmitoleic source is from anchovies.
Hodson L, Karpe F. Is there something special about palmitoleate? Curr Opin Clin Nutr Metab Care. 2013;16(2):
Stetten D, Schoenheimer R. The conversion of palmitic acid into stearic and palmitoleic acid in rats. J Biol Chem 1940;133:

12. Palmitoleic acid has heart health benefits
Clinical data shows that supplementation with palmitoleic acid has beneficial effect on cardiovascular risk markers
HDL
Palmitoleic acid supplementation
Moving on to the cardiovascular benefits of the principal fatty acids in the Mega10 formula.
Supplementation with palmitoleic acid has been shown to improve several cardiovascular risk factors in human clinical studies. Supplementation led to reductions in plasma hsCRP, and the Mega10 claim for hsCRP reduction is as a result of palmitoleic acid in the formula. Other beneficial effects of supplementation were a reduction in plasma triglycerides, a reduction in LDL cholesterol, and an increase in HDL cholesterol.
CRP TG
LDL
Bernstein et al. J Clin Lipidol. 2014;8(6):612-7

13. Clinical Study on Omega 7 Palmitoleic Acid
Double-blind randomized, placebo-controlled study with 60 subjects
Subjects with elevated CRP (2-5mg/L)
and dyslipidemia (n=60)
Baseline blood samples: CRP and plasma lipids
randomized
220.5mg palmitoleic acid
(n = 30)
Placebo
Control
(n = 30)
Link reference to Bernstein paper on iPads
Also… weblink is – currently free online:
30 days
Follow-up blood samples: hsCRP and plasma lipids
Bernstein AM, Roizen MF, Martinez L, (2014) Clin Lipidol. 8(6):612-7.

14. Randomized Double Blind Study on Palmitoleic Acid Supplementation: reduction in CRP
44%
decrease *
CRP (mg/L)
RCT of adults with dyslipidemia and CRP between 2 and 5mg/L were randomized to receive 220.5mg of cis-palmitoleic acid or placebo capsule for 30 days. N=30 per group.
* Significantly different from placebo arm
pre
post
pre
post
Bernstein et al. J Clin Lipidol . 2014;8:612-7

15. Health Benefits of Omega-3s
Widely studied with over 20,000 published scientific papers that support health benefits
Fish Oil, a good source of Omega-3, helps support cardiovascular health
Omega-3 EPA & DHA helps reduce serum triglyceride levels
Triglycerides
Balk E, Chung M, Lichtenstein A, et al. Evid Rep Technol Assess (Summ). 2004;93:1-6.

16. Hypertriglyceridemia is prevalent in Canadian adults
men
women
>1.7mmol/L
Plasma triglyceride
concentration cut-offs
mmol/L
Mildly elevated
mmol/L
Moderately elevated
5.5-10mmol/L
High
>19mmol/L
Very high
Watts et al. Nat Rev Cardiol, :
Riediger & Clara CMAJ 2011:183:E

17. OmegaGenics Mega 10 Purified & Concentrated
Each softgel provides 105 mg of palmitoleic acid from concentrated omega-7, purified to remove palmitic acid
Palmitic acid is a saturated fatty acid which has negative impact on important aspects of heart health
Many unpurified palmitoleic acid preparations may contain high concentrations of palmitic acid
Also provides a concentrated dose of 500 mg of combined Omega 3 EPA and DHA in each easy-to- swallow, enteric softgel with a natural lemon flavor

18. OmegaGenics Mega 10 Targeted Enhanced Support
Helps reduce blood levels of C-reactive protein, an inflammatory marker
Helps reduce serum triglycerides
Purified Omega-7 fatty acid processed to remove palmitic acid
Enteric softgels helps reduce the likelihood of repeating (burp-up)
Concentrated dose in easy-to-swallow softgels with a natural lemon flavor
OmegaGenics TruQuality purity guarantee – every batch is tested by a third-party lab and undergoes additional testing in-house for guaranteed purity.

19. OmegaGenics Mega 10 Practitioner Tools
Detail Aid
MET1949CAN
Patient Card
MET1948CAN
Sample Card MEGASAMCAN
Are these on pitcher for links?
Mega 10TM
Digital Frame
Shelf Talker
MET2181CAN

20. OmegaGenics Mega 10 Webinars
October 28, 2015, November (TBD), December (TBD)
Experiences with an Omega 7+3 Combination
Case Study (unpublished)
Speaker: Alison Monette, ND
Explain the unique attributes of Mega10
Discuss patient cases in which Mega10 was used as a single therapeutic change
Discuss patient cases in which Mega10 was used as part of a regimen of therapeutic approaches

21. OmegaGenics Mega 10 Education Tools Case Series Write up
Endured Webinar
Clinical Study
Case Series Write up
Research Review

22. OmegaGenics Mega 10 Practitioner: $30.90 Retail: $51.50
Price & Promotion
Price
Practitioner: $30.90
Retail: $51.50
Promotion
Buy 9, Get 10% Off
Buy 12, Get 15% Off