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Introduction to FRACTALS

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1 Introduction to FRACTALS
Larry Liebovitch, Ph.D. Florida Atlantic University 2004

2 Non-Fractal

3 Fractal

4 Partial List of Acknowledgments
Florida Atlantic University Center for Complex Systems Dr. J. A. S. Kelso Department of Psychology Dr. David Wolgin Continuing Education Dr. Phyllis Jonas Graphics Adrien Spano Instructional Services W. Douglas Trabert Harvard University Pulmonary Critical Care Unit Dr. Barney Hoop Telecommunications Manager Peg Doyle

5 Non - Fractal Size of Features 1 cm 1 characteristic scale

6 Fractal Size of Features 2 cm 1 cm 1/2 cm 1/4 cm many different scales

7 Self-Similarity Water Water Water Land Land Land

8 Scaling The value measured for a property depends on the resolution at which it is measured.

9 Dimension 2 3 1 4

10 Statistical Properties
moments may be zero or non-finite. for example, mean variance

11 Self-Similarity Geometrical
The magnified piece of an object is an exact copy of the whole object.

12 Self-Similarity Statistical Q(ar) = kQ(r)
The value of statistical property Q(r) measured at resolution r, is proportional to the value Q(ar) measured at resolution ar. Q(ar) = kQ(r) d pdf [Q(ar)] = pdf [kQ(r)]

13 Branching Patterns nerve cells in the retina, and in culture
Caserta, Stanley, Eldred, Daccord, Hausman, and Nittmann 1990 Phys. Rev. Lett. 64:95-98 Smith Jr., Marks, Lange, Sheriff Jr., and Neale 1989 J. Neurosci, Meth. 27:

14 Branching Patterns air ways blood vessels in the retina in the lungs
Family, Masters, and Platt 1989 Physica D38:98-103 Mainster 1990 Eye 4: West and Goldberger 1987 Am. Sci. 75:

15 Variations in Time cell height above a substrate
Giaever and Keese 1989 Physica D38: PC DATA ACQUISITION AND PROCESSING SMALL GOLD ELECTRODE (10-1 CM2) LARGE GOLD COUNTER (101 CM2) 4000 Hz AC SIGNAL 1 VOLT LOCK-IN AMPLIFIER V t CELLS TISSUE CULTURE MEDIUM (ELECTROLYTE)

16 cell height above a substrate
Variations in Time cell height above a substrate Giaever and Keese 1989 Physica D38: 5.4 5.8 5.0 5.7 5.6 5.2 5.6 4.8 5.5 mV (a measure of the average height) 200 400 600 800 1000 20 40 60 80 100 5.78 5.77 5.74 5.76 2 4 6 8 10 0.0 0.4 0.8 min min

17 voltage across the cell membrane
Variations in Time voltage across the cell membrane Churilla, Gottschalke, Liebovitch, Selector, Todorov, and Yeandle 1996 Ann. Biomed. Engr. 24:99-108 -5 mV -12 1 3 4 2 5 sec

18 Currents Through Ion Channels
ATP sensitive potassium channel in cell from the pancreas Gilles, Falke, and Misler (Liebovitch 1990 Ann. N.Y. Acad. Sci. 591: ) FC = 10 Hz 5 sec FC = 1k Hz 5 pA 5 msec

19 Closed Time Histograms potassium channel in the corneal endothelium
Liebovitch et al Math. Biosci. 84:37-68 Number of closed Times per Time Bin in the Record Closed Time in ms

20 Closed Time Histograms potassium channel in the corneal endothelium
Liebovitch et al Math. Biosci. 84:37-68 Number of closed Times per Time Bin in the Record Closed Time in ms

21 Closed Time Histograms potassium channel in the corneal endothelium
Liebovitch et al Math. Biosci. 84:37-68 Number of closed Times per Time Bin in the Record Closed Time in ms

22 Closed Time Histograms potassium channel in the corneal endothelium
Liebovitch et al Math. Biosci. 84:37-68 Number of closed Times per Time Bin in the Record A/D =170 Hz Closed Time in ms

23 ? How is the body formed? Heart Brain DNA 1,000,000 capillaries
100,000 genes ? Heart 100,000,000,000 nerve cells Brain DNA

24 Repeated Application of these Rules
How is the body formed? Self-Similar Structures Repeated Application of these Rules Heart Rules Brain DNA

25 Q (r) = B rb Self-Similarity Scaling
Q (ar) = k Q(r) Q (r) = B rb Self-Similarity can be satisfied by the power law scaling: Q (r) = B rb Proof: using the scaling relationship to evaluate Q(a) and Q(ar), Q (r) = B rb Q (ar) = B ab rb if k = ab then Q (ar) = k Q (r)

26 Q (r) = B rbf ( ) where f(1+x) = f(x)
Self-Similarity Scaling Q (ar) = k Q(r) Q (r) = B rb f(Log[r]/Log[a]) Self-Similarity can be satisfied by the more complex scaling: log r log a Q (r) = B rbf ( ) where f(1+x) = f(x) Proof: using the scaling relationship to evaluate Q(a) and Q(ar), log r log a Q (r) = B rbf ( ) log ar log a log ar + log r log a Q (ar) = B ab rbf ( ) = Babrbf ( ) log ar log a log r log a = B ab rbf ( ) = Babrbf ( ) 1+ if k = ab then Q (ar) = k Q (r)

27 Scaling Relationships
most common form: Power Law Q (r) = B rb Q (r) Log Q (r) the measuremnt Logarithm of measurement Log r r resolution used to make the measurement Logarithm of the resolution used to make the measurement

28 Scaling Relationships
less common, more general form: log r log a Q (r) = B rb f ( ) Q (r) Log Q (r) the measuremnt Logarithm of measurement r Log r resolution used to make the measurement Logarithm of the resolution used to make the measurement

29 How Long is the Coastline of Britain?
Richardson 1961 The problem of contiguity: An Appendix to Statistics of Deadly Quarrels General Systems Yearbook 6: AUSTRIALIAN COAST 4.0 CIRCLE SOUTH AFRICAN COAST 3.5 Log10 (Total Length in Km) GERMAN LAND-FRONTIER, 1900 WEST COAST OF BRITIAN 3.0 LAND-FRONTIER OF PORTUGAL 1.0 1.5 2.0 2.5 3.0 3.5 LOG10 (Length of Line Segments in Km)

30 Scaling of Membrane Area
Paumgartner, Losa, and Weibel 1981 J. Microscopy 121:

31 imi inner mitochondrial membrane omi outer mitochondrial membrane
er endoplasmic reticulum 30 [1 - D] [1 - D] 10 -0.54 imi -0.09 omi BOUNDARY LENGTH DENSITY IN M-1 -0.72 er 1 4 6 8 10 20 40 60 x10-6 RESOLUTION SCALE M-1

32 teff in msec Scaling of Ion Channel Kinetics keff in Hz
Liebovitch et al Math. Biosci. 84:37-68 70 pS Channel, on cell, Corneal Endothelium 1000 100 keff in Hz effective kinetic rate constant 10 1 1 10 100 1000 teff in msec effective time scale

33 Two Interpretations of the Fractal Scalings
Structural The scaling relationship reflects the distribution of the activation energy barriers between the open and closed sets of conformational substates. closed open Energy

34 Two Interpretations of the Fractal Scalings
Dynamical The scaling relationship reflects the time dependence of the activation energy barrier between the open and closed states. t3 t2 t1 closed time Energy open

35 Biological Examples of Scaling Relationships
spatial area of endoplasmic reticulum membrane area of inner mitochondrial membrane area of outer mitochondrial membrane diameter of airways in the lung size of spaces between endothelial cells in the lung surface area of proteins

36 Biological Examples of Scaling Relationships
temporal kinetics of ion channels reaction rates of chemical reactions limited by diffusion washout kinetics of substances in the blood

37 Scaling Resolution 1 cm Perimeter = 8 cm Perimeter = 12 cm Resolution

38 Scaling one measurement: not so interesting
scaling relationship: much more interesting one value slope the measuremnt Logarithm of the measuremnt Logarithm of Logarithm of the resolution used to make the measurement Logarithm of the resolution used to make the measurement

39 DIMENSION The dimension tells us how many new pieces we see when
A quantitative measure of self-similarity and scaling The dimension tells us how many new pieces we see when we look at a finer resolution.

40 Space filling properties of an object
Fractal Dimension Space filling properties of an object e.g. Self-similarity dimension Capacity dimension Hausodorff-Besicovitch dimension

41 Topological Dimension how points within an object are connected
e.g. covering dimension iterative dimension

42 the space that contains an object
Embedding Dimension the space that contains an object

43 Self-similarity Dimension
Fractal Dimensions Self-similarity Dimension N new pieces when each line segment is divided by M. N = Md 3 = 31 d = 1 1 2 3

44 Self-similarity Dimension
Fractal Dimensions Self-similarity Dimension N new pieces when each line segment is divided by M. N = Md 1 2 3 9 = 32 d = 2 4 5 6 7 8 9

45 Self-similarity Dimension
Fractal Dimensions Self-similarity Dimension N new pieces when each line segment is divided by M. N = Md 27 = 33 d = 3 1 2 3 4 5 6 7 8 9

46 N (r) balls of radius r needed to cover the object
Fractal Dimensions Capacity Dimension N (r) balls of radius r needed to cover the object

47 Relationship to self-similarity dimension: M = 1/r, then N = Md
Fractal Dimensions Capacity Dimension d = lim Log N(r) r 0 Log N( ) 1 r Relationship to self-similarity dimension: M = 1/r, then N = Md

48 Hausdorff-Besicovitch Dimension
Fractal Dimensions Hausdorff-Besicovitch Dimension Ai = covering sets

49 H(S,r) = inf (diameter Ai)S
Fractal Dimensions Capacity Dimension H(S,r) = inf (diameter Ai)S i r 0 lim H(s,r) = for all s < d H(s,r) = 0 for all s > d r 0 lim

50 Fractal Dimension of the Perimeter of the Koch Curve
1 1 1 1 1 1 1

51 Fractal Dimension of the Perimeter of the Koch Curve
2 3 1 4 1 2 3 When we look at 3x finer relolution, we see 4 additional smaller pieces.

52 Fractal Dimension Perimeter of the Koch Curve
Log (number of new pieces) d= Log (factor of finer resolution) Log 4 Log 3 = =

53 Fractal Dimension of an
Object by Box Counting

54 N(r) = Number of Boxes to Cover the Set
r = Box Size N(r) = Number of Boxes to Cover the Set r = 1 N = 1

55 N(r) = Number of Boxes to Cover the Set
r = Box Size N(r) = Number of Boxes to Cover the Set r = 1/2 N = 3

56 N(r) = Number of Boxes to Cover the Set
r = Box Size N(r) = Number of Boxes to Cover the Set r = 1/4 N = 11

57 N(r) = Number of Boxes to Cover the Set
r = Box Size N(r) = Number of Boxes to Cover the Set r = 1/8 N = 26

58 N(r) = 1.03r -1.60 100 N(r) 10 1 .1 r 1 Log N (r) Log (1/r) d =
d = - slope Log N (r) Log (r) = - = 1.60 1 .1 r 1 Fast Box Counting Algorithms: Liebovitch & Toth 1989 Phys. A141: Hou et al Phys. Lett. A151: Block et al Phys. Rev. A42:

59 Fractal Dimension Determined from the Scaling Relationship
in general dimension: N(r) is the number of pieces found at resolution r N (r) r -d scaling relationship of the property Q(r) measured from the data Q(r) r -b theory on how property Q(r) depends on N(r) and r Q(r) [N(r)] [r] - b d = Thus, the dimension:

60 Fractal Dimension Determined from the Scaling Relationship
for the length of the coastline of Britain: N(r) r -d Richardson’s measurement of the length of the coastline Q(r) r -.25 The length is the number of line segments times the length of each line segment. Q(r) N(r)r r1-d Thus, the dimension: d = 1.25

61 Topological Dimensions
always an integer Covering Dimension in a minimal covering, each point of the object is covered by no more than G sets. d = G - 1 for a plane: G = 3 d = = 2

62 Topological Dimensions
always an integer Iterative Dimension Borders of D dimensional space have dimension D - 1. Find the borders of the borders. Repeat H times until 0 dimensional. d = H step #1 step #2 for a plane: d = 2 d = 2

63 Fractals can live inside integer dimension spaces:
Embedding Dimension Fractals can live inside integer dimension spaces: A chemical reaction can occur in 1, 2, or 3 dimensional space.

64 Embedding Dimension Fractals can live inside
non-integer dimension spaces: A chemical reaction can also occur in a fractal dimensional space.

65 Definition of a Fractal
d (fractal) > d (topological)

66 example: perimeter: d (fractal) = d (topological) = 1. > 1. d (fractal) > d (topological) Perimeter: covers more space than a 1-D line covers less space than a 2-D area

67 fragmented, many pieces fractional dimension
“FRACTAL” fragmented, many pieces fractional dimension

68 Pulmonary Hypertension
HIGH BLOOD PRESSURE IN THE LUNGS Boxt, Katz, Czegledy, Liebovitch, Jones, Reid, & Esser 1990 Circ. Suppl, lll, 82: 100 D = 1.65 normal 20% 02

69 Pulmonary Hypertension
HIGH BLOOD PRESSURE IN THE LUNGS Boxt, Katz, Czegledy, Liebovitch, Jones, Reid, & Esser 1990 Circ. Suppl, lll, 82: 100 D = 1.53 hypoxic 10% 02

70 Pulmonary Hypertension
HIGH BLOOD PRESSURE IN THE LUNGS Boxt, Katz, Czegledy, Liebovitch, Jones, Reid, & Esser 1990 Circ. Suppl, lll, 82: 100 D = 1.43 hyperoxic 90% 02

71 Biological Examples where the Fractal Dimension has been Measured
surfaces of proteins surface of cell membranes growth of bacterial colonies islands of types of lipids in cell membranes

72 Biological Examples where the Fractal Dimension has been Measured
dendrites of neurons blood flow in the heart blood vessels in the eye, heart, and lung shape of herpes simplex ulcers in the cornea

73 Biological Examples where the Fractal Dimension has been Measured
textures of X-rays of bone and teeth texture of radioisotope tracer in the liver

74 Biological Examples where the Fractal Dimension has been Measured
action potentials from nerve fibers opening and closing of ion channels

75 Biological Examples where the Fractal Dimension has been Measured
vibrations in proteins concentration dependence of reaction rates of enzymens

76 Fractal Dimension Numerical Measure of Self-Semilarity

77 Numerical Measure of Correlatlions in Space or Time
Fractal Dimension Numerical Measure of Correlatlions in Space or Time

78 Numerical Measure of Normal versus Sick
Fractal Dimension Numerical Measure of Normal versus Sick D = 1.3 D = 1.1

79 Fractal Dimension Mechanism D = 1.7 Mechanism: Diffusion Limited
Aggregation D = 1.7

80 Non - Fractal Mean More Data

81 Fractal Mean Mean More Data More Data

82 The Average Depends on the Amount of Data Analyzed
each piece

83 The Average Depends on the Amount of Data Analyzed
average size average size or number of pieces included number of pieces included

84 The Average Depends on the Amount of Data Analyzed
f1x1 + f2x2 + f3x fnxn mean = f1 + f2 + f fn f is the number of pieces of size x lim lim xi mean = xi f1x1 + f2x2 + f3x fnxn f1 + f2 + f fn = 0 Contributions to the mean dominated by the many f1 of the smallest sizes x1.

85 The Average Depends on the Amount of Data Analyzed
lim lim mean = xi xi f1x1 + f2x2 + f3x fnxn f1 + f2 + f fn = Contributions to the mean dominated by the few fn of the biggest sizes xn.

86 Toss a coin. If it is tails win $0, If it is heads win $1.
Ordinary Coin Toss Toss a coin. If it is tails win $0, If it is heads win $1. The average winnings are: = 0.5 1/2 Non-Fractal

87 The average winnings are:
St. Petersburg Game (Daniel Bernoulli) Feller 1968 An Introduction to Probability Theory and its Applications. vol. 1, Wiley, pp Toss a coin. If it is heads win $2, if not, keep tossing it until it falls heads. If this occurs on the N-th toss we win $2N. With probability 2-N we win $2N. H $2 TH $4 TTH $8 TTTH $16 The average winnings are: = = Fractal

88 St. Petersburg Game Ordinary Coin Toss N Trials
Fractal Mean Winnings after N Trials Ordinary Coin Toss Non-Fractal N Trials

89 Non-Fractal Log avg density within radius r Log radius r

90 density within radius r
Fractal Meakin 1986 In On Growthand Form: Fractal and Non-Fractal Patterns in Physics Ed. Stanley & Ostrowsky, Martinus Nijoff Pub., pp Log radius r .5 -1.0 -2.0 -1.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0 4.5 5.0 5.5 6.0 -2.5 Log avg density within radius r

91 Brown and Scholz 1985 J. Geophys. Res 90:12,575-12,582.
Fractal Edges of Rocks Brown and Scholz 1985 J. Geophys. Res 90:12,575-12,582. Height Distance

92 Brown and Scholz 1985 J. Geophys. Res 90:12,575-12,582.
Fractal Edges of Rocks Brown and Scholz 1985 J. Geophys. Res 90:12,575-12,582. 103 RMS Hight ( ) ___ Palisades I S-Plume ...... Profile Length ( ) 10-3 101 106

93 Electrical Activity of Auditory Nerve Cells
Teich, Jonson, Kumar, and Turcott 1990 Hearing Res. 46:41-52 Data: action potentials voltage time

94 Electrical Activity of Auditory Nerve Cells
Teich, Jonson, Kumar, and Turcott 1990 Hearing Res. 46:41-52 Divide the record into time windows: Count the number of action potentials in each window: 2 6 3 1 5 1 Firing Rate = 2, 6, 3, 1, 5,1

95 Electrical Activity of Auditory Nerve Cells
Teich, Jonson, Kumar, and Turcott 1990 Hearing Res. 46:41-52 Repeat for different lengths of time windows: 8 4 6 Firing Rate = 8, 4, 6

96 Electrical Activity of Auditory Nerve Cells
Teich, Jonson, Kumar, and Turcott 1990 Hearing Res. 46:41-52 150 The variation in the firing rate decreases slowly at longer time windows. 140 T = 50.0 sec T = 5.0 sec 130 120 110 FIRING RATE 100 90 80 70 T = 0.5 sec 60 4 8 12 16 20 24 28 SAMPLE NUMBER (each of duration T sec)

97 Statistical Analysis of Action
Teich, Johnson, Kumar, and Turcott 1990 Hearing Res. 46:41-52 T Counts in the windows are: 2, 4, 3, 1, 1, 1

98 Statistical Analysis of Action
Teich, Johnson, Kumar, and Turcott 1990 Hearing Res. 46:41-52 Determine the Mean and Varience of the counts. # Determine the Pulse Number Distribution: Number (#) of windows of size T with n counts. n counts in a window

99 Statistical Analysis of Action
Teich, Johnson, Kumar, and Turcott 1990 Hearing Res. 46:41-52 Pulse Number Distibution 1.0 T = 50 ms T = 200 ms as, the PND becomes more Gaussian Pulse number distribution 0.0 0.0 n 4.0 0.0 n 16.0 Non-Fractal Vestibular Neuron

100 Statistical Analysis of Action
Teich, Johnson, Kumar, and Turcott 1990 Hearing Res. 46:41-52 Pulse Number Distibution 0.25 T = 50 ms T = 200 ms as, the PND becomes less Gaussian Pulse number distribution 0.0 0.0 14.0 0.0 40.0 Fractal Auditory Neuron

101 Statistical Analysis of Action
Teich, Johnson, Kumar, and Turcott 1990 Hearing Res. 46:41-52 Fano Factor = Mean/Variance The Fano Factor = Variance/Mean increases with the window length T for the auditory neurons. Westerman 101 Teich and Khanna Kumar and Johnson Theory Fano factor , var(n)/<n> 100 10-1 10-0 10-3 10-2 10-1 10-0 10-1 10-2 Window length, T, seconds

102 Bassingthwaighte and van Beek 1988 Proc. IEEE 76:693-699
Blood Flow in the Heart Bassingthwaighte and van Beek 1988 Proc. IEEE 76: When the blood flow is measured using smaller pieces, the relative dispersion increases. Data 64 RD total Linear regression 32 RD = standard deviation mean 16 RD, relative dispersion, % RD m1- d 8 d = 1.2 4 0.1 1.0 10.0 m, size of tisssue samples, grams

103 Bassingthwaighte and van Beek 1988 Proc. IEEE 76:693-699
Blood Flow in the Heart Bassingthwaighte and van Beek 1988 Proc. IEEE 76: Model a = .5 + (1-a)(1-a)F (1-a)aF aaF a (1-a)F aF (1-a)F F

104 Volume of Consecutive Breaths
Hoop, Kazemi, and Liebovitch 1990 FASEB J. 4(4): A1105 Hurt Rescaled Range Analysis R = range of the deviation of the running sum from the mean over a time window of length T S = standard deviation over a time window of length T R / S = rescaled range T = time window in which R / S is measured

105 Volume of Consecutive Breaths
2 Volume of Consecutive Breaths Hoop, Kazemi, and Liebovitch 1990 FASEB J. 4(4): A1105 2 Log R/S 3 Log T

106 Is Evolution an Editor or a Composer?
2 Is Evolution an Editor or a Composer? Luria & Delbruck 1943 Genetics 28: (Claims, Overbaugh & Miller 1988 Nature 335: : Levin, Gordon & Stewart 1989 preprint) Experiment: Let the colony grow and then challenge it with a killer virus. Determine the number of mutant cells at the end of each experiment.

107 Is Evolution an Editor or a Composer? Random Mutations + Selection
2 Is Evolution an Editor or a Composer? Luria & Delbruck 1943 Genetics 28: (Claims, Overbaugh & Miller 1988 Nature 335: : Levin, Gordon & Stewart 1989 preprint) experiment #1 Random Mutations + Selection Directed Mutations killer virus

108 Is Evolution an Editor or a Composer? Random Mutations + Selection
2 Is Evolution an Editor or a Composer? Luria & Delbruck 1943 Genetics 28: (Claims, Overbaugh & Miller 1988 Nature 335: : Levin, Gordon & Stewart 1989 preprint) experiment #2 Random Mutations + Selection Directed Mutations killer virus

109 Is Evolution an Editor or a Composer? Random Mutations + Selection
2 Is Evolution an Editor or a Composer? Luria & Delbruck 1943 Genetics 28: (Claims, Overbaugh & Miller 1988 Nature 335: : Levin, Gordon & Stewart 1989 preprint) experiment #3 Random Mutations + Selection Directed Mutations killer virus

110 BIG variation (Lea & Coulson Distribution)
2 Is Evolution an Editor or a Composer? Luria & Delbruck 1943 Genetics 28: (Claims, Overbaugh & Miller 1988 Nature 335: : Levin, Gordon & Stewart 1989 preprint) How much is the variation inthe number of mutants cells? BIG variation (Lea & Coulson Distribution) LITTLE variation (Poisson Distribution)

111 If the probability of a mutation per cell = =
2 Random Mutations Lea & Coulson 1949 J. Genetics 49: Mandelbrot 1074 J. Appl. Prob. 11: If the probability of a mutation per cell = = 1 2-4 16

112 + = Random Mutations FOR EACH GENERATION: Number Probability of cells
2 Random Mutations Lea & Coulson 1949 J. Genetics 49: Mandelbrot 1074 J. Appl. Prob. 11: FOR EACH GENERATION: Probability per cell of one Mutation Number of cells in this generation + =

113 X = Random Mutations FOR EACH GENERATION: (continued) Probability
2 Random Mutations Lea & Coulson 1949 J. Genetics 49: Mandelbrot 1074 J. Appl. Prob. 11: FOR EACH GENERATION: (continued) Probability of one Mutation in this generation Number of offspring at the end X =

114 Random Mutations FOR EACH GENERATION: (continued) Expected
2 Random Mutations Lea & Coulson 1949 J. Genetics 49: Mandelbrot 1074 J. Appl. Prob. 11: FOR EACH GENERATION: (continued) Expected Number of Mutants at the end from this generation

115  Random Mutations 2 = St. Petersburg Game Prob. Winnings Total
Lea & Coulson 1949 J. Genetics 49: Mandelbrot 1074 J. Appl. Prob. 11: Prob. Winnings Total = St. Petersburg Game

116 there are fluctuations
2 Fractal Power Spectra P(f) If the variance , then there are fluctuations at ALL scales, and P(f) = 1 f

117 electrical activity when the heart contracts
2 in time electrical activity when the heart contracts QRS Spectrum 4 Goldberger, Bhargava, West, and Mandell 1985 Biophys. J. 48: log (amplitude)2 2 0.2 0.6 1.0 1.4 1.8 log (harmonic)

118 log (spatial frequency)
2 in space radioactive isotope distribution in the liver Cargill, Barrett, Fiete, Ker, Pattton, and Seeley 1988 SPIE 914 Medical Imaging II, pp 8 7.5 Slope = -3.95 Diagnosis: NORMAL 7 6.5 log (power spectrum)2 6 5.5 5 4.5 4 0.3 0.5 0.7 0.9 1.1 log (spatial frequency)

119 2 When the moments, such as the mean and variance, don’t exist, what should I measure? You should measure how a property Q(r) depends on the resolution r used to measure it. Log Q(r) Log r measure this slope

120 2 Examples of Q(r) Mean e.g. average density within a circle as a function of the radius of that circle Meakin 1986 In On Growth and Form, ed. Stanley & Ostrowksy Nijhoff. pp

121 Examples of Q(r) Relative Dispersion (standard deviation / mean)
2 Examples of Q(r) Relative Dispersion (standard deviation / mean) e.g. relative dispersion of blood flow as a function of the mass of the tissue sample Bassingtwaighte and van Beek 1988 Proc. IEEE 76:

122 Examples of Q(r) Fano Factor (variance / mean)
2 Examples of Q(r) Fano Factor (variance / mean) e.g. Fano factor of the number of action potentials within time windows as a function of the length of time windows Teich, Johnson, Kumar, and Turcott 1990 Hearing Res. 46:41-52

123 Examples of Q(r) Mean Squared Deviation
2 Examples of Q(r) Mean Squared Deviation e.g. mean squared deviation of a walk generated from the base pair sequence in DNA as a function of the length along the DNA Peng et al Nature 356:

124 Examples of Q(r) Hurst Rescaled Range
2 Examples of Q(r) Hurst Rescaled Range e.g. maximum minus the minimum value of the running sum of the deviations from the mean normalized by the standard deviation of volumes of breaths measured within a time window as a function of the length of the time window Hoop et al Chaos 3:27-29

125 Biological Examples of the Statistical Properties of Fractals
2 Biological Examples of the Statistical Properties of Fractals action potentials in nerve cells blood flow in the heart volumes of consecutive breaths mutations electrical activity of the heartbeat

126 Biological Examples of the Statistical Properties of Fractals
2 Biological Examples of the Statistical Properties of Fractals distribution of tracer in the liver membrane voltage of T-lymphocytes base pair sequence in DNA durations of consecutive breaths

127 Statistical Properties
2 Statistical Properties Fractals What they taught you in school Stable Distributions Gaussian Gaussian

128 Statistical Properties
2 Statistical Properties Non-Fractal Fractal moments nonzero, finite moments , finite

129 Statistical Properties
2 Statistical Properties Non-Fractal Fractal statistical tests to tell if parameters differ at different times or between different experimental conditions: t, F, ANOVA non-parametric statistical tests to tell if parameters differ at different times or between different experimental conditions: ?

130 More Statistical Lessons
2 More Statistical Lessons nonstationary This word means that the moments do not exist. (The moments do not reach finite. limiting values.) It does not mean that the mechanism that produced the data is changing in time. mean time

131 More Statistical Lessons
2 More Statistical Lessons BIG variance? Check its limiting value. Maybe, it’s

132 More Statistical Lessons
Bad: one measurement Good: slope Logarithm of the moment one value Logarithm of the moment slope Logarithm of the resolution used to make the measurement Logarithm of the resolution used to make the measurement

133 CHAPTER 6 SUMMARY Summary of Fractals
Where to Learn More About Fractals

134 Summary of Fractal Properties
Self-Similarity Pieces resemble the whole.

135 Summary of Fractal Properties
Scaling The value measured depends on the resolution.

136 Summary of Fractal Properties
Dimension How many new pieces are found as the resolution is increased.

137 Summary of Fractal Properties
Statistical Properties Moments may be zero or infinite.

138 Books About Fractals Classic B.B. Mandelbrot
The Fractal Geometry Of Nature 1983 W.H.Freeman

139 More Books About Fractals
Mathematics G.A. Edgar Measure, Topology, and Fractal Geometry 1990 Springer-Verlag M. Barnsley Fractals Everywhere Academic Press

140 More Books About Fractals
Physics & Chemistry J. Feder Fractals 1988 Plenum D. Avnir The Fractal Approach to Heterogeneous Chemistry John Wiley & Sons

141 More Books About Fractals
Elementary & Biology J. Bassingthwaighte, L. Liebovitch, & B. West Fractal Physiology 1994 Oxford Univ. Press


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