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John T. Daugirdas, MD, Thomas A

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1 KDOQI Clinical Practice Guideline for Hemodialysis Adequacy: 2015 Update 
John T. Daugirdas, MD, Thomas A. Depner, MD, Jula Inrig, MD, MHS, Rajnish Mehrotra, MD, Michael V. Rocco, MD, MSCE, Rita S. Suri, MD, MSc, FRCPC, Daniel E. Weiner, MD, MS, Nancy Greer, PhD, Areef Ishani, MD, MS, Chief, Roderick MacDonald, MS, Carin Olson, MD, MS, Indulis Rutks, BS, Yelena Slinin, MD, MS, Timothy J. Wilt, MD, MPH, Michael Rocco, MD, MSCE, Holly Kramer, MD, Michael J. Choi, MD, Milagros Samaniego-Picota, MD, Paul J. Scheel, MD, MBA, Kerry Willis, PhD, Jessica Joseph, MBA, Laura Brereton, MSc John T. Daugirdas, MD, Thomas A. Depner, MD, Jula Inrig, MD, MHS, Rajnish Mehrotra, MD, Michael V. Rocco, MD, MSCE, Rita S. Suri, MD, MSc, FRCPC, Daniel E. Weiner, MD, MS, Nancy Greer, PhD, Areef Ishani, MD, MS, Chief, Roderick MacDonald, MS, Carin Olson, MD, MS, Indulis Rutks, BS, Yelena Slinin, MD, MS, Timothy J. Wilt, MD, MPH, Michael Rocco, MD, MSCE, Holly Kramer, MD, Michael J. Choi, MD, Milagros Samaniego-Picota, MD, Paul J. Scheel, MD, MBA, Kerry Willis, PhD, Jessica Joseph, MBA, Laura Brereton, MSc  American Journal of Kidney Diseases  Volume 66, Issue 5, Pages (November 2015) DOI: /j.ajkd Copyright © 2015 National Kidney Foundation, Inc. Terms and Conditions

2 Figure 1 Systematic errors from 2 commonly used linear formulas based on percent reduction in urea concentration (PRU). The formula of Basile et al136 has less error than the equation of Jindal et al137 in the usual range, but it overestimates the dose in the critical area of Kt/V<1.0. Reproduced with permission of the American Society of Nephrology from Daugirdas.138 American Journal of Kidney Diseases  , DOI: ( /j.ajkd ) Copyright © 2015 National Kidney Foundation, Inc. Terms and Conditions

3 Figure 2 Data from the Netherlands Cooperative Study showing a marked increase in risk of death in patients with no residual native kidney function (KrT/V). Data source: Termorschuizen et al.140 American Journal of Kidney Diseases  , DOI: ( /j.ajkd ) Copyright © 2015 National Kidney Foundation, Inc. Terms and Conditions

4 Figure 3 Delivered dialysis doses in the HEMO (Hemodialysis) Study. (A) A clear separation of the delivered dialysis doses expressed as standard Kt/V was achieved for all patients during the HEMO Study. (B) When normalized to BSA, women randomized to the high dose received a dose comparable to the conventional dose in men.129 Reproduced with permission of the American Society of Nephrology from Daugirdas et al.147 American Journal of Kidney Diseases  , DOI: ( /j.ajkd ) Copyright © 2015 National Kidney Foundation, Inc. Terms and Conditions


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