1. Antacids
Acid Base Chemistry

2. http://redpoll. pharmacy. ualberta
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9. Antacids

10. 12.2 Antacids
State and Explain how excess acidity in the stomach can be reduced by the use of different bases.
Antacids: bases, metal oxides, hydroxides, carbonates, hydrogen carbonates
Reacts with stomach acid (excess) to adjust the stomach pH to the desired level

11. Purpose of HCl in the stomach
To suppress growth of harmful bacteria
To help in digestion by hydrolyzing proteins to amino acids
Normal pH of stomach acid ~
1.2 – 0.3 range,
Stress also produces more acid

12. Role of antacids
Neutralizes the excess acids and relives the discomfort
Excess acid can cause ulcers

13. Examples: Over the Counter
Al(OH)3 Mg(OH)2 CaCO3
NaHCO3

14. Alginates Antacids are combined with Alginates
extracted from brown sea weeds
produces neutralizing layer that prevents acid reflux / acid entering into oesophagus

15. Dimethicone / Antifoaming agent
Are added to antacids to reduce the surface tension of gas bubbles
And produce de-foaming action

16. Silicon Chemistry
The possibilities offered to the formulation chemist by silicone chemistry are endless and yours to explore.

17. Active ingredients of some commercial antacids
Tums: CaCO3 MgCO3 Mg Si3O8
For the treatment of gastritis and of ulcers
Rolaids : AlNa(OH)2CO3
Malox : Al(OH) Mg(OH)2
Alka Seltzer : NaHCO3 , citric acid, aspirin

18. Alka Seltzer : NaHCO3 , citric acid, aspirin

19. Active ingredients of some commercial antacids
Milk of Magnesia : Mg(OH)2 or MgO/Mg(OH)2 mixture
Amphogel Al(OH)3
Di-Gel : CaCO3

20. Action of Antacids Alkalosis: high doses of antacids basic stomach
Mg2Si3O HCl SiO2(s)
2 H2O (l) MgCl2(aq)
Write the reactions for rest of the antacids
Alkalosis: high doses of antacids
basic stomach
Other problems: body produces more acids