1. Example of the storage location of the sample folder
Attention
The demonstration uses sample data installed on your PC along with AIST-MeRAM. So, even if you don’t have any data at hand, you can start risk assessment with AIST-MeRAM.
As shown below, sample data are normally stored in the folder of your choice.
e.g. Computer -> Local Disk (C:) -> Program Files (x86) -> AIST-MeRAM_ENG -> SAMPLEDATA
Example of the storage location of the sample folder

2. Demonstration of Detailed Assessment Using AIST-MeRAM
Risk Assessment by Detail Mode
Exposure Assessment
Hazard Assessment
Risk Characterization
Risk Management
Practice: Repeat the steps following the handouts and sample data

3. Detailed Assessment Exposure Assessment Hazard Assessment Risk
2012/8/31
Exposure
Assessment
Hazard
Assessment
Risk
Assessment
Risk
Management
TierⅠof Primary Risk Assessment
Detailed Assessment of Exposure Concentration

4. Detailed Assessment (exposure assessment) Step 1/12
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Detailed Assessment (exposure assessment) Step 1/12
Select “Detailed
Assessment” mode.
Select “Create
New File”
select “Exposure
Assessment”.

5. Detailed Assessment (exposure assessment) Step 2/12
Check this box to display a list of previously-assessed substances for reassessment.
Check this box for assessment of existing substances using toxicity data contained in the tool.
Select a target substance from the “Search Results List”.
Search box can be used for partial name/number match.

6. Detailed Assessment (exposure assessment) Step 3/12
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Detailed Assessment (exposure assessment) Step 3/12 　
Select an assessment method.

7. Detailed Assessment (exposure assessment) Step 4/12
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Detailed Assessment (exposure assessment) Step 4/12 　
Select “estimate an emission amount”
Use your own data (estimated or measured) OR
Use PRTR data

8. Detailed Assessment (exposure assessment) Step 5/12
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Detailed Assessment (exposure assessment) Step 5/12　
Enter the title of emission factor you want to register.
If use categories are not defined in CSCL (e.g. cosmetics), you can specify emission factor. OR
Select this option to define your own emission factors using Japanese CSCL emission factors as template

9. Detailed Assessment (exposure assessment) Step 6/12
Register emission factors for each stage using CSCL data sets as templates.
< Manufacturing stage >
< Formulation stage >
< Industrial use stage >
< Household/Commercial use stage >
Register your own Removal rate of sewage treatment plant

10. Detailed Assessment (exposure assessment) Step 7/12
Upload a list of CSCL notification information for detailed assessment.
The list is normally stored in “Programs Files (X86)” -> “AIST-MeRAM_ENG” -> “SAMPLE” on C drive.

11. Detailed Assessment (exposure assessment) Step 8/12
List of uploaded
information

12. Detailed Assessment (exposure assessment) Step 9/12
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Detailed Assessment (exposure assessment) Step 9/12　
Enter physical property data. If the target substance is designated as a PRTR substance under the Japanese law, its physical property data is automatically displayed.

13. Detailed Assessment (exposure assessment) Step 10/12
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Detailed Assessment (exposure assessment) Step 10/12
If you don’t have environmental parameters, you can use the default data contained in the tool.
Check this box if you know the river flow. The tool will estimate exposure concentration in the real environment.

14. Detailed Assessment (exposure assessment) Step 11/12
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Detailed Assessment (exposure assessment) Step 11/12
Check assessment settings.
To change settings, click the “Back” button or select an appropriate menu in the upper left window.

15. Detailed Assessment (exposure assessment) Step 12/12
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Detailed Assessment (exposure assessment) Step 12/12
Result sheet of exposure assessment using CSCL emission factor data sets.
Estimated exposure concentrations by life stage and use category
Data settings entered by user

16. Detailed Assessment Exposure Assessment Hazard Assessment Risk
2012/8/31
Exposure
Assessment
Hazard
Assessment
Risk
Assessment
Risk
Management
TierⅠof Primary Risk Assessment)
Detailed Assessment of Exposure Concentration

17. Detailed Assessment (exposure assessment) Step 1/6
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Detailed Assessment (exposure assessment) Step 1/6
Select “Reassess” in the result sheet of the previous exposure assessment.
As you go back to the “Confirm” window, select “Assessment Model” in the left pane.

18. Detailed Assessment (exposure assessment) Step 2/6
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Detailed Assessment (exposure assessment) Step 2/6
As you go back to this window, change the assessment model to “Detailed Assessment of Exposure Concentration”.

19. Detailed Assessment (exposure assessment) Step 3/6
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Detailed Assessment (exposure assessment) Step 3/6
Select watershed model data.
Select the file named “Environmental Concentration Data_River Model_SAMPLE” which normally stored in “Programs Files (X86)” -> “AIST-MeRAM_ENG” -> “SAMPLE” on C drive.
Upload data from the sample data storage folder.

20. Detailed Assessment (exposure assessment) Step 4/6
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Detailed Assessment (exposure assessment) Step 4/6
Watershed model data is uploaded and displayed.
Select a type of exposure distribution you want to generate.

21. Detailed Assessment (exposure assessment) Step 5/6
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Detailed Assessment (exposure assessment) Step 5/6
Check assessment settings.
To change settings, click the “Back” button or select an appropriate menu in the upper left window.

22. Detailed Assessment (exposure assessment) Step 6/6
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Detailed Assessment (exposure assessment) Step 6/6
Result sheet of exposure assessment using watershed model data
Environmental concentration data used for assessment
Distribution of exposure concentrations

23. Copper chloride is used as a sample substance for detailed assessment.
2012/8/31
Exposure
Assessment
Hazard
Assessment
Risk
Assessment
Risk
Management
Species Sensitivity Distribution (HC5)
Copper chloride is used as a sample substance for detailed assessment.

24. Detailed Assessment(hazard assessment) Step 1/12
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Detailed Assessment(hazard assessment) Step 1/12
Select “Create
New File”.
Select “Hazard Assessment” in Assessment Steps.

25. Detailed Assessment (hazard assessment) Step 2/12
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Detailed Assessment (hazard assessment) Step 2/12
Check this box to display a list of previously-assessed substances for reassessment.
Check this box for assessment of existing substances using toxicity data contained in the tool.
Select a target substance from the “Search Results List”.
Search box can be used for partial name/number match.

26. Detailed Assessment (hazard assessment) Step 3/12
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Detailed Assessment (hazard assessment)
Step 3/12
Among the toxicity databases contained in the tool, select ones you want to use for assessment.
You can add your own toxicity data as well.

27. Detailed Assessment (hazard assessment) Step 4/12
Select “species sensitivity distribution” methodology for hazard assessment.

28. Detailed Assessment (hazard assessment) Step 5/12
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Detailed Assessment (hazard assessment) Step 5/12
Select a reliability level of toxicity data.

29. Detailed Assessment (hazard assessment) Step 6/12
Select the uncertainty factor.

30. Detailed Assessment (hazard assessment) Step 7/12
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Detailed Assessment (hazard assessment) Step 7/12
Select statistical methods you want to use for assessment.
Check assessment settings.
To change settings, click the “Back” button or select an appropriate menu in the upper left window.

31. Detailed Assessment (hazard assessment) Step 8/12
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Result sheet of hazard assessment by SSD
Click “Reassess”.
PNEC and Uncertainty Factor derived for risk assessment
In order to confirm/edit these data, you should click “Reassess”.

32. Detailed Assessment (hazard assessment) Step 9/12
Confirm/Edit toxicity data

33. Detailed Assessment (hazard assessment) Step 10/12
Select these data
Save the edited toxicity data
Delete these data

34. Detailed Assessment (hazard assessment) Step 11/12

35. Detailed Assessment (hazard assessment) Step 12/12
Result sheet of hazard assessment by SSD
The data after confirm/edit was used for SSD distribution

36. Detailed Assessment Hazard Assessment Exposure Assessment Risk
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Detailed Assessment
Hazard
Assessment
Exposure
Assessment
Risk
Assessment
Risk
Management

37. Detailed Assessment (risk assessment) Step 1/5
Select “Risk Assessment” in Assessment Steps.
Go back to the Assessment Steps window by clicking the red square button.
Select “Create
New File”.

38. Detailed Assessment (risk assessment) Step 2/5
List of possible risk assessment combinations (hazard and exposure assessment results) is automatically displayed by the tool.

39. Detailed Assessment (risk assessment) Step 3/5
Result sheet of Risk assessment

40. Detailed Assessment (risk assessment) Step 4/5
Results shown as MOE (Deterministic Risk)
Result sheet of risk assessment by combination of “species sensitivity distribution ” and “risk assessmentⅠ under CSCL”.
Result shown as MOE
MOE>UF No risk
MOE<=UF Have risk
MOE<UF

41. Detailed Assessment (risk assessment) Step 5/5
Result sheet of risk assessment by combination of “species sensitivity distribution ” and “distribution of exposure concentration” (watershed model data)
Results shown as EPAF
(Probabilistic Risk)
Risk is characterized as EPAF (Expected Potentially Affected Fraction). In this tool, if EPAF<0.01, risk is considered acceptable.

42. Detailed Assessment (risk management)
Hazard
Assessment
Exposure
Assessment
Risk
Assessment
Risk
Management

43. Detailed Assessment (risk management 1/4)
Select “Risk Management” in Assessment Steps.
Go back to the Assessment Steps window by clicking the red square button.

44. Detailed Assessment (risk management 2/4)
Select a risk assessment file （Hazard Quotient + Risk Assessment I under CSCL） for risk management.
Select “risk management options” for risk management.

45. Detailed Assessment (risk management 3/4)No
Finish

46. Detailed Assessment (risk management 4/4)
Finish
Yes

47. Example of the storage location of the sample folder
Attention
The demonstration uses sample data installed on your PC along with AIST-MeRAM. So, even if you don’t have any data at hand, you can start risk assessment with AIST-MeRAM.
As shown below, sample data are normally stored in the folder of your choice.
e.g. Computer -> Local Disk (C:) -> Program Files (x86) -> AIST-MeRAM_ENG -> SAMPLEDATA
Example of the storage location of the sample folder