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APOE and aging-related cognitive change in a longitudinal cohort of men  Ville Rantalainen, Jari Lahti, Markus Henriksson, Eero Kajantie, Pentti Tienari,

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Presentation on theme: "APOE and aging-related cognitive change in a longitudinal cohort of men  Ville Rantalainen, Jari Lahti, Markus Henriksson, Eero Kajantie, Pentti Tienari,"— Presentation transcript:

1 APOE and aging-related cognitive change in a longitudinal cohort of men 
Ville Rantalainen, Jari Lahti, Markus Henriksson, Eero Kajantie, Pentti Tienari, Johan G. Eriksson, Katri Raikkonen  Neurobiology of Aging  Volume 44, Pages (August 2016) DOI: /j.neurobiolaging Copyright © 2016 Elsevier Inc. Terms and Conditions

2 Fig. 1 Estimated marginal means for cognitive ability total and subtest scores at 67.6 years according to the number of minor alleles in rs (A) and rs (B) polymorphisms. Error bars represent standard errors. The p-values are adjusted for APOE major isoforms, age at cognitive testing, maximum attained lifetime occupational status, and population stratification. Cognitive ability scores are standardized to mean = 100, standard deviation = 15. Neurobiology of Aging  , DOI: ( /j.neurobiolaging ) Copyright © 2016 Elsevier Inc. Terms and Conditions

3 Fig. 2 Change in cognitive ability total and subtest scores between 20.1 and 67.6 years according to the number of minor alleles in rs and rs polymorphisms. Bars represent change scores, error bars represent standard errors. The p-values are adjusted for APOE major isoforms, age at cognitive testing, maximum attained lifetime occupational status, and population stratification (A and C), and in APOE ε3/3 homozygotes for age at cognitive testing, maximum attained lifetime occupational status, and population stratification (B and D). Neurobiology of Aging  , DOI: ( /j.neurobiolaging ) Copyright © 2016 Elsevier Inc. Terms and Conditions

4 Supplementary Figure 1 Change in cognitive ability total and subtest scores between 20.1 and 67.6 years in APOE ε3/3, ε2/3 and ε4/2, ε4/3 and ε4/4 carriers. Bars represent change scores, error bars represent standard errors. The p-values are adjusted for age at cognitive testing, maximum attained lifetime occupational status, and population stratification. The p-value before slash compares APOE ε3/3 versus ε2/3. The p-value after slash compares APOE ε3/3 versus ε4/2, ε4/3 and ε4/4. Neurobiology of Aging  , DOI: ( /j.neurobiolaging ) Copyright © 2016 Elsevier Inc. Terms and Conditions

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