1. Male Genital System Testis & epididymidis Ductus deferrens
Prostata & vesiculae seminales
Penis

2. Testis
Necrosis
Atrophy
Inflammation
Tumours

3. Atrophia testium Cryptorchidism Klinefelter´s sy
estrogen administration
hypopituitarism
aging
malnutrition
cachexia
radiation chemotherapy
alcoholic cirrhosis

4. Granulomatous orchitis
infectious
syphlis
tuberculosis
leprosy
fungi
brucellosis
parasites
rickettsiae….
idiopathic
trauma
ischemia
postobstructive changes
G- urinary tract infection...
mimicking a neoplasm PSEUDOTUMOUR

5. Germ cell tumours seminoma embryonal carcinoma
teratoma (mature, immature)
yolc sac tumour
choriocarcinoma
RISK FACTOR: CRYPTORCHIDISM x increased

6. Seminoma (50%) „classic“ spermatocytic
frequent as both pure & combined
peak incidence 40 years
swelling
monomorphous germinal cell population
may present with metastases
c-kit + (membranously)
spermatocytic
rare (1% of all seminomas)
peak incidence 50 years
swelling
polymorphous cell population
does not metastasize!
dif. dg. anaplastic seminoma

7. Embryonal carcinoma
composed of primitive anaplastic-appearing epithelial cells
pure rare, mostly in combined germ cell tumours
peak incidence 30 years
swelling, 2/3 patients with metastases at diagnosis
macro : tan/gray, necroses, hemorrhages
micro: solid, tubular, PLAP, CK +

8. Mesoblastoma vitellinum- yolc sac tumour –endodermal sinus tumour
80% of prepubertal germ cell tumours
in postpubertal as admixture
painless mass, serum AFP elevated
macro: gray/tan nonencapsulated
micro: many variants – microcystic, solid,festoon-like, hepatoid, spindle cell…
AFP+, alpha1-Antitrypsin

9. Choriocarcinoma pure – 0,5% of testicular tumours
admixture in many germ cell tumours
highly malignant
postpubertal , 2nd-3rd decade
presents often with metastases
beta-HCG

10. Teratomas
Def.:
Tumours (benign or malignant) composed of two or more different cell lines that are NOT normally present in the place of tumour origin

11. Teratoma coetaneous – differentiated -cystic
embryonal – nondifferentiated solid

12. Prostate
Necrosis , atrophy
Inflammation
HYPERPLASIA
CARCINOMA

13. (Benign) Prostatic Hyperplasia
starting over 40, 90% men over years of age
dyshormonal, often symptomless
dysuria - retention:
infection, infarction, stones
hydropyelonephritis, urosepsis

14. Carcinoma prostatae frequent by chance finding at autopsy
most men die with, not from the prostate cancer
etiology unknown
Serum PSA, sonography discovering clinically silent forms
hormonal dependency
precanceroses PIN (LG, HG)

15. Diagnosis of the Prostate Cancer
PSA, thick needle biopsy
histology
immunohistochemistry
34β E12, PSA
grading : Gleason grade (1-5) & score (2-10)
staging

16. Penis congenital anomalies acquired
hypospadia, epispadia (changed positions of the urethra openings)
phimosis paraphimosis
acquired
infections
neoplasms