1. Improved dose determination for Molecular Radiotherapy
Andrew Robinson
Dave Cullen
Nuclear Physics Group, The University of Manchester
Jill Tipping
David Hamilton
The Christie NHS Foundation Trust

2. Christie Research Huddle – 07/04/14

3. Christie Research Huddle – 07/04/14

4. Scatter Correction Triple Energy Window Sensitivity Factor
Christie Research Huddle – 07/04/14

5. TRT with 177Lu-DOTATATE 177Lu: t1/2 = 6.647 days bbeta (177Lu) = 100%
bgamma (177Hf) = 18% EM SC
RAW
TEW
Clinical problem:
First figure
Attempting to follow course of therapeutic radionuclide over course of several days
Range of activities covered several GBq to few hundred MBq WB Hundred to single finger MBq in tumours Signal to background ratios >20:1 to 3:1
Sizes covered WB, organ size eg liver ( 1700ml) , tumour size few 10s of mls
Second figure
Scatter look at projection in tomogram in energy window, can use scatter window/s to get estimate of scatter in emission ; scatter component can be significant % and above
Figure three can try and correct for scatter.
See affect of correction of scatter on tomographic slice
Pictures look better, but how does ability to quantify do over all these conditions?
5000 MBq
300 MBq
Day 0
Day 6
Christie Research Huddle – 07/04/14

6. Simulation - Camera Collimator and touch plate Crystal PMT array
Back compartment
Shielding
Bed and mattress
Christie Research Huddle – 07/04/14

7. Simulation - Phantom
Christie Research Huddle – 07/04/14

8. Simulation - Sources 99mTc T1/2 = 6.0 hrs Bgamma = 0.999963 (140 keV)
Bbeta = (112 keV mean energy)
177Lu
T1/2 = days
Bgamma = (113, 208 keV daughter nucleus)
Bbeta = (134.2 keV mean energy)
90Y
T1/2 = hrs
Bgamma = (1.76 MeV daughter nucleus)
Bbeta = (933 keV mean energy)
Bpositron = (daughter nucleus)

9. Simulation - Sources 99mTc T1/2 = 6.0 hrs Bgamma = 0.999963 (140 keV)
Bbeta = (112 keV mean energy)
177Lu
T1/2 = days
Bgamma = (113, 208 keV daughter nucleus)
Bbeta = (134.2 keV mean energy)
90Y
T1/2 = hrs
Bgamma = (1.76 MeV daughter nucleus)
Bbeta = (933 keV mean energy)
Bpositron = (daughter nucleus)
Bremsstrahlung

10. Cluster Gate 6.1 Gate 6.2 Gate 7.0(beta) Geant 4.9.4 Geant 4.9.5
Geant 4.10 (MT)
Christie Research Huddle – 07/04/14

11. Cluster 264 cores 76 TB storage nucpc76.ph.man.ac.uk
FASTPC2
x2 Xeon 2.27GHz
8 Cores (16 with Hyper Threading)
nucpc90.ph.man.ac.uk
FASTPC3
x2 Xeon 2.4GHz
8 Cores (16 with Hyper Threading)
nucpc91.ph.man.ac.uk
FASTPC4
x2 Xeon 2.4GHz
8 Cores (16 with Hyper Threading)
264 cores
76 TB storage
nucpc96.ph.man.ac.uk
FASTPC5
x2 Xeon 2.4GHz
8 Cores (16 with Hyper Threading)
nucpc97.ph.man.ac.uk
FASTPC6
x4 AMD Opteron 2.3GHz
48 Cores
nucpc108.ph.man.ac.uk
FASTPC8
x4 AMD Opteron 2.2GHz
64 Cores
nucpc115.ph.man.ac.uk
FASTPC9
x4 AMD Opteron 2.2GHz
64 Cores
nucpc116.ph.man.ac.uk
FASTPC10
x4 AMD Opteron 2.2GHz
64 Cores

12. Improved Scatter Correction
“Is it possible to have a scatter correction method which provides accurate quantification and improved image quality which is applicable in ALL conditions?
Quantification
Image Quality

13. Triple Energy Window Correction
Infinia Hawkeye
Simulation (all events)
Unscattered events
ICMP 2013 – Brighton (4th September)

14. Triple Energy Window Correction
Infinia Hawkeye
Simulation (all events)
Unscattered events
EM1
EM2
K. Ogawa et al, IEEE Trans. Med. Imaging, 10, (1991)
Scat

15. Pre reconstruction TEW Whole Image
Christie Research Huddle – 07/04/14

16. Pre reconstruction TEW Whole Image
Christie Research Huddle – 07/04/14

17. 3D Printing
Use 3D printing to produce phantom inserts based on CT images.
Sensitivity Factor
Partial Volume effects
Patient specific measurements
Christie Research Huddle – 07/04/14

18. 3D Printing
Christie Research Huddle – 07/04/14

19. 3D Printing
Christie Research Huddle – 07/04/14

20. 3D Printing
Christie Research Huddle – 07/04/14