1. Features of adult GH deficiency Improved by GH replacement?
Features of adult growth hormone (GH) deficiency syndrome and response to therapy (adapted from Reference 65 and other sources)
Features of adult GH deficiency
Improved by GH replacement?
 Fat mass (especially abdominal fat)‏
Yes
 Lean body mass
Yes
 Muscle strength
Yes
 Cardiac capacity
Yes
 Red blood cell volume
Yes
 Exercise performance
Yes
Atherogenic lipid profile*
Probably
 Total cholesterol
 LDL-C
 TG
 HDL-C
 fibrinogen and PAI-1
* Abbreviations: LDL-C, low-density lipoprotein cholesterol; TG, triglycerides; HDL-C, high-density lipoprotein cholesterol; PAl-1, plasminogen activator inhibitor-1
Abbildung mod. nach Cummings, 2003

2. Features of adult GH deficiency Improved by GH replacement?
Features of adult growth hormone (GH) deficiency syndrome and response to therapy (adapted from Reference 65 and other sources)
Features of adult GH deficiency
Improved by GH replacement?
 Atherosclerosis
No data
 Life expectancy
No data
 Bone mineral density
Yes (after 1 year of treatment)‏
Thin, dry skin; poor venous access
Probably
Defective sweating
Yes
Psychosocial problems
Yes
low self-esteem
depression
fatigue/listlessness
sleep disturbances
anxiety emotional lability and impared self control
social isolation
poor marital and socioeconomic performance
Abbildung mod. nach Cummings, 2003