1. (Syndrome X, Insulin Resistance syndrome)
Metabolic Syndrome
(Syndrome X, Insulin Resistance syndrome)

2. 25% of pop, nonobese, nondiabetic
=> Hyperglycemia (not nessisary DM)
=> Triacylglycerides + low HDL
=> BP
=> Syndrome X

3. Epidemiology USA: 44% in pop >50y (60%w, 45%m)
France: y <10%, >65y 17,5%
Increasing risk with age

4. Diagnostic criteria NCEP:ATPIII criteria 3 or more:
Waist circumference >102cm (M),>88cm (W)
Hypertriglyceridemia: >or= 150mg/dl
HDL <40mg/dl (M), <50 (W)
Hypertension: >130/85
Fasting plasma glucose >100mg/dl (or diagnosed DM 2)

5. Pathophysiology
Insulin resistance
Hyperlipidemia

6. Symptoms

7. Symptoms only associated with other diseases.

8. Features + LDL Hyperuricidemia Abd obesity Prothrombotic state
Plasminogen activator inhibitor type 1 (PAI-1)
Proinflammatory state

9. Associated diseases Cardiovascular inc stroke and MI Type 2 diabetes
Non alcoholic fatty liver disease
Polysystic ovary syndrome
Obstructive sleep apnea

10. Treatment
LIFESTYLE
DIET
PHYSICAL ACTIVITY

11. Medication Appetitesuppresants: Phentermine
Absorption inhibitors:Orlistat
Statins: LDL+ triacylglycerides+ HDL
Fibrates/Nicotinic acid: Triacyl glycerides
Antihypertensives
Metformin: Glucose
Thiazolidinediones: Glucose