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C. Transgenic mice that express the CaMKII-Asp286 kinase and receive doxycycline perform as well as wild-type mice in learning the Barnes maze task (approximately 65% of animals learn the task), whereas transgenic mice without the doxycycline (in which the kinase is highly expressed) do not learn the task. Source: Prefrontal Cortex, Hippocampus, and the Biology of Explicit Memory Storage, Principles of Neural Science, Fifth Editon Citation: Kandel ER, Schwartz JH, Jessell TM, Siegelbaum SA, Hudspeth AJ, Mack S. Principles of Neural Science, Fifth Editon; 2012 Available at: Accessed: October 07, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved
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