2. SMART-Starters WHAT ARE 3 VIRUSES THAT YOU KNOW OF? 1 - 2 - 3 -
WHAT Disease/Symptoms do EACH cause?

3. WHAT ARE THE VIRUSES YOU HAVE HEARD OF?
HW:
Read Text 18.2 pg
Take notes under the four main headings
Answer Questions 1-3 on page 531
Phino
Sled dog run to Nome 1925

4. VIRUSES
Ebola virus particles, colored digitally, emerging from a type of monkey epithelial cell line

5. Outline Anatomy of a Virus Are viruses alive? Common Viral Diseases
Viral Replication
Lytic
Lysogenic
Retroviruses

6. Should you Vaccine or not?
Common Viral Diseases
Measles…
Immune Response.
Should you Vaccine or not?

7. What is a virus?
A non-living strand of genetic material within a protein coat
Size?

8. Another way to talk about Size…how many base pairs does the viral DNA/RNA contain?

9. Anatomy of a Virus
Receptors - To initiate the infection cycle, all viruses require an interaction between a surface molecule—the receptor—and a protein or proteins on the surface of the virion. This interaction is highly specific viral particles lacking envelope glycoproteins are noninfectious, and cells lacking a receptor are non-permissive for viral entry.

10. Embedded into the cell and the virus’ envelope are:
Glycoproteins?
AKA: Keys = Antigens (proteins)
Locks = Receptors on target cell
Receptors - To initiate the infection cycle, all viruses require an interaction between a surface molecule—the receptor—and a protein or proteins on the surface of the virion. This interaction is highly specific viral particles lacking envelope glycoproteins are noninfectious, and cells lacking a receptor are non-permissive for viral entry.
Antigens are foreign particles, usually proteins, which are capable of generating an immune response in the body, a property known as immunogenicity.
This immune response consists of specific antibodies which are generated by plasma cells as a result of exposure to a specific epitope presented by the antigen.

11. Special thanks to Dr. Dennis Kunkel www.denniskunkel.com
Viral Shapes
Special thanks to Dr. Dennis Kunkel

12. 4 Basic Shapes
Helical
Polyhedral
Spherical
Bacteriophage

13. Helical Resemble Long Rods Flexible or rigid Examples TMV Ebola Rabies
Tobacco Mosaic Virus

14. Helical Viruses cont. Tobacco Mosaic Virus Agricultural Disease
RNA is nuclear material
Tobacco Mosaic Virus

15. Polyhedral Polyhedral means many sided 3-D shape
Most are iscosahedrons
Examples
Adenovirus
Polio virus
Common cold
Hepatitis
Adenovirus causes respiratory infections
Adenovirus

16. Polyhedral cont. Pappilomavirus Polio Virus Causes warts
Can induce tumors
Can eventually cause cancer
Pappilomavirus
Polio Virus

17. Spherical Also called “enveloped” viruses Roughly spherical
Protein coat and DNA/RNA covered by an membrane envelope
Influenza Virus

18. More Spherical Viruses
Chickenpox
Fever Blisters
Mononucleosis
Herpes Simplex Virus

19. HIV
Mature virus:budding and release in lymph node tissue

20. Human Immunodeficiency Virus
A Deadly Sphere
Infection in lymph tissue: Budding mature virus
Human Immunodeficiency Virus

21. Bacteriophage Most complex viruses Infect bacteria Consist of:
Capsid (head)
DNA inside
Tail
Tail Plate
Tail fibers (legs)

23. Are Viruses Alive? Characteristics of living things? – List them.
DiscoveryNews: Are Viruses Alive?

24. Viral Infection  Viral Replication
Lytic Cycle
&
Lysogenic Cycle
NPR: Viruses Attack

26. VIRAL REPLICATION ACTIVITY

27. I'm a Virus! (Mr. W's Virus Rap)
What are the differences between lysogenic and lytic cycles of Virus Replication?

28. Retro Virus

29. How they really look…

30. REVERSE Transcriptase
UNIQUE PART…
RNA  DNA  inserted into nucleus
REVERSE Transcriptase

31. Study HELP Resources NPR: Viruses Attack
Discovery News: Are Viruses Alive?
EC: Virus Evolution (10 points possible – See Website)
Bozeman Science: Viruses (9 min.)
KHAN Academy: Viruses
Amoeba Sisters: Viruses (7 Min.)

32. SMART-Starters WHAT ARE THREE VIRUSES THAT YOU KNOW OF?
WHAT Disease/Symptoms do EACH cause?

33. SMART-Starters
What are two aspects of a VIRUS that are similar to living things?
What are two aspects of a VIRUS that are similar to non-living things?

34. SMART-Starters
What is difference between an HIV virus and a bacteriophage?
Possible differences: How are they different in…
size?
shape?
target host cell?
other?

35. SMART-Starters
What are the four shapes of viruses. Draw each.

36. What is the difference between the lytic and lysogenic cycles in viral replication?
SMART-Starters
HINT: Use this diagram to come up with 3 differences
SMART-Starter

37. SmartSTARTER
Identify and name structures A, B, C, and D. A B C D